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Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer
( Yuk Fai Lam ),( Wai Kay Seto ),( Teresa Tong ),( Ka Shing Cheung ),( Oswens Lo ),( Ivan Fn Hung ),( Wai Lun Law ),( Wai K Leung ) 대한장연구학회 2018 Intestinal Research Vol.16 No.4
Background/Aims: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. Methods: Consecutive CRC patients who had undergone surgical resec tion for curative intent in our hospital between 2001 and 2004 were identified. R-sided colonic cancers refer to cancer proximal to splenic flexure whereas L-sided cancers include rectal cancers. Patients were included only if they had a clearing colonos copy performed either before or within 6 months after the operation. Findings of surveillance colonoscopy performed up to 5 years after colonic resection were included in the analysis. Results: Eight hundred and sixty-three CRC patients underwent curative surgical resection during the study period. Three hundred and twenty-seven patients (107 R-sided and 220 L-sided) fulfilled the inclusion criteria and had at least 1 postoperative surveillance colonoscopy performed. The proportion of patients who had polyp and adenoma on surveillance colonoscopy was significantly higher among patients with L-sided than R-sided cancers (polyps: 30.9% vs. 19.6%, P=0.03; adenomas: 25.5% vs. 13.1%, P=0.01). The mean number of adenoma per patient on surveillance colonoscopy was also higher for patients with L-sided than R-sided tumors (0.52; 95% confidence interval [CI], 0.37-0.68 vs. 0.22; 95% CI, 0.08-0.35; P<0.01). Multivariate analysis showed that L-sided cancers, age, male gender and longer follow-up were independent predictors of adenoma detection on surveillance colonoscopy. Conclusions: Patients with L-sided cancer had a higher rate of metachronous polyps and adenoma than those with R-sided cancer on surveillance colonos copy. (Intest Res 2018;16:619-627)
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Non-magnetic compliant finger sensor for continuous fine motor movement detection
Anterpal Sandhu,Yasong Li,Nicholas Peatfield,Xin Yi Yong,Ryan D’Arcy,Carlo Menon,Teresa P. L. Cheung 대한의용생체공학회 2017 Biomedical Engineering Letters (BMEL) Vol.7 No.3
A non-magnetic MEG compatible device hasbeen developed that provides continuous force and velocityinformation. Combined with MEG, this device may findutility in characterizing brain regions associated with forceand velocity relative to individual digits or movementpattern. 15 healthy right-handed participants were givenvisual cues to perform random finger movements on theprototype finger sensor for 21 s and then rest for 21 s (7times). Respective finger flexion data were obtained, during151-channel MEG brain scanning, by feeding the signalfrom finger sensor into four input Analog to Digital Converter(ADC) channels in the MEG hardware. The sourceactivity was reconstructed in beta band using a LinearlyConstrained Minimum Variance (LCMV) beamformer inthe beta band. The ADC channels were used as regressorsfor a continuous time General Linear Model (GLM) and aRegion of Interest (ROI) was identified to examine activity. MEG analysis showed bilateral activation in the primarymotor cortex region. Because individual digits could beisolated in the ADC data, somatotopy of the fingers wereobserved consistent with the homunculus except pinkyfinger. The total span was calculated to be 5.5662 mm. Thestudy confirms that the finger sensor is magneticallycompatible with MEG measurements and may potentiallyprovide a means to study complex sensorimotor functions. Improved isolation of individual digit information alongwith the use of machine learning algorithms can helpretrieve more accurate results.
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