ON A SEQUENCE OF KANTOROVICH TYPE OPERATORS VIA RIEMANN TYPE q-INTEGRAL

Gulen Bascanbaz-Tunca,Fatma Tasdelen,Aysegul Erencin 대한수학회 2014 대한수학회보 Vol.51 No.2

In this work, we construct Kantorovich type generalization of a class of linear positive operators via Riemann type q-integral. We obtain estimations for the rate of convergence by means of modulus of continuity and the elements of Lipschitz class and also investigate weighted approximation properties.

Controlling Robot Arms with Kinect Sensor

R. Gurfidan,K. Tasdelen 한국디지털융합학회 2022 IJICTDC Vol.7 No.2

The necessity of automation gradually increases by increasing industrialization at the present. Needed workforce is supplied on occasion of being short of manpower or threatening man’s health. It brings about a rapid improvement in the robotics world. All the used robot technologies in automatic systems performed by this time, fulfil the given commands as they are prearranged, or they can be momentarily controlled by the help of remote controls that are designed for the control of the system. In this thesis study, it is purposed that designed robot arms can be commanded simultaneously and one-to one with articulation motions of man’s arms by using Kinect technology. In this performed study, prearranged robot’s arms can be momentarily controlled by Kinect sensor. Motions of arm sensed by Kinect are transformed into mathematical data in software which is fixed for Kinect and then the process of leading servo motor, composed robot’s articulations, is achieved by sending the data to software fixed for Arduino. The ability to control Kinect as a software is supplied with WPF (Windows Presentation Foundation) and programming of Arduino is supplied with C++ program language.

Nasogastric tube placement into the hepaticojejunostomy anastomosis in pancreaticoduodenectomy

Bulent Kaya,Yetkin Ozcabi,Iksan Tasdelen,Ender Onur,Kemal Memisoglu 한국간담췌외과학회 2016 한국간담췌외과학회지 Vol.20 No.2

Hepaticojejunostomy is an important part of many surgical procedures including pancreaticoduodenectomy. Biliary leakage from hepaticojejunostomy may be associated with intraabdominal abscess formation, biliary peritonitis, and even mortality. A 72-year-old female patient was admitted to our hospital with obstructive jaundice. After initial evaluation, she was diagnosed with distal common bile duct obstruction without accurate diagnosis. Before planned pancreaticoduodenectomy, biliary drainage with a T-tube was performed due to the presence of cholangitis. After the first operation, pancreaticoduodenectomy was performed. Postinflammatory changes around the hilar region made the hepaticojejunostomy risky. A bilio-digestive anastomosis was performed using a new technique. A nasogastric tube was placed into the common bile duct proximal to the anastomosis. The postoperative course of the patient was uneventful. The use of a nasogastric tube as a stent in risky hepaticojejunostomies is a simple technique that can be beneficial.

Nasogastric tube placement into the hepaticojejunostomy anastomosis in pancreaticoduodenectomy

Bulent Kaya,Yetkin Ozcabi,Iksan Tasdelen,Ender Onur,Kemal Memisoglu 한국간담췌외과학회 2016 Annals of hepato-biliary-pancreatic surgery Vol.20 No.2

Hepaticojejunostomy is an important part of many surgical procedures including pancreaticoduodenectomy. Biliary leakage from hepaticojejunostomy may be associated with intraabdominal abscess formation, biliary peritonitis, and even mortality. A 72-year-old female patient was admitted to our hospital with obstructive jaundice. After initial evaluation, she was diagnosed with distal common bile duct obstruction without accurate diagnosis. Before planned pancreaticoduodenectomy, biliary drainage with a T-tube was performed due to the presence of cholangitis. After the first operation, pancreaticoduodenectomy was performed. Postinflammatory changes around the hilar region made the hepaticojejunostomy risky. A bilio-digestive anastomosis was performed using a new technique. A nasogastric tube was placed into the common bile duct proximal to the anastomosis. The postoperative course of the patient was uneventful. The use of a nasogastric tube as a stent in risky hepaticojejunostomies is a simple technique that can be beneficial.

Comparison of mechanical and tribological properties of glass-fiber-reinforced polyketone and polyketone/polyamide 6 blend composites

Uysal Irem Nehir,Mehmet Atilla Tasdelen 한국고분자학회 2024 Macromolecular Research Vol.32 No.7

In this study, the impact of two compatibilizers, ethylene terpolymer (C1) and maleic anhydride grafted polyethylene (C2), on the mechanical, thermal, and tribological properties of 30% glass-fiber-reinforced polyketone (PK) and polyketone/polyamide 6 (PK/PA-6) blend composites was investigated. In the case of 30% glass-fiber-reinforced PK composites, the mechanical test results showed that C2 significantly improves the impact resistance (over 48.8%) and elongation at break (over 13.3%) values due to the enhanced compatibility between glass fibers and the PK matrix, attributed to the maleic anhydride functionality. The tensile and flexural properties of the 30% glass-fiber-reinforced PK/PA-6 blend composites were determined to be between the values of pure PK/GF30 and PA-6/GF30 composites, which were its constituent components. Notably, these blend composites displayed higher impact resistance (19.6 kJ/m2) and elongation at break (4.86%) values than the pure PK/GF30 and PA-6/GF30 composites. The SEM images suggested that C2 creates a better interface between glass fibers and the matrix, resulting in a more cohesive structure. Differential scanning calorimeter analysis revealed two distinct glass transition temperatures, indicating the existence of two phases, and reflecting the immiscibility of the two polymers. Tribological studies showed that the friction coefficients and specific wear rates of PK/PA-6/GF30 composites were improved by increasing PK segment. The PK-25/PA6-50/GF30-C2 sample exhibited a friction coefficient of 0.341 μ and a specific wear rate of 1.15 10 ¯6 mm3/ Nm. Overall, the C2 proved to be a more suitable compatibilizer than C1, offering valuable insights for tailoring high-performance materials with enhanced properties.

ON A SEQUENCE OF KANTOROVICH TYPE OPERATORS VIA RIEMANN TYPE q-INTEGRAL

Bascanbaz-Tunca, Gulen,Erencin, Aysegul,Tasdelen, Fatma Korean Mathematical Society 2014 대한수학회보 Vol.51 No.2

In this work, we construct Kantorovich type generalization of a class of linear positive operators via Riemann type q-integral. We obtain estimations for the rate of convergence by means of modulus of continuity and the elements of Lipschitz class and also investigate weighted approximation properties.

Genetic Variation at D1S80 Locus in the Turkish Population

Melahat Kurtulus Ulkuer,Uner Ulkuer,Ibrahim Semizoglu,Bahar Tasdelen,Tahsin Kesici 한국유전학회 2005 Genes & Genomics Vol.27 No.3

Association of miR-1266 with Recurrence/Metastasis Potential in Estrogen Receptor Positive Breast Cancer Patients

Sevinc, Elif Demirdogen,Egeli, Unal,Cecener, Gulsah,Tezcan, Gulcin,Tunca, Berrin,Gokgoz, Sehsuvar,Tasdelen, Ismet,Tolunay, Sahsine,Evrensel, Turkkan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

The Homeobox B13 (HOXB13):Interleukin 17 Receptor B (IL17BR) index of estrogen receptor (ER)-positive breast cancer (ER (+) BC) patients may be a potential biomarker of recurrence/ metastasis. However, effects of microRNA (miRNA) binding to the 3' untranslated region (3' UTR) of HOXB13 and IL17BR and its function on recurrence/metastasis in ER (+) BC remains elusive. The aims of this study were to determine the expression of miRNAs that bind to 3' UTR of HOXB13 and IL17BR in ER (+) BC patients and asess the effects of these miRNAs on recurrence/metastasis. The expression profiles of HOXB13 and IL17BR were evaluated using RT-PCR in tumors and normal tissue samples from 40 ER (+) BC patients. The expression level of 4 miRNAs, which were predicted to bind the 3' UTR of HOXB13 and IL17BR using TargetScan, microRNA.org and miRDB online databases, were further evaluated with RT-PCR. Our findings demonstrated that high miR-1266 levels might be significant prognostic factor for recurrence/metastasis occurrence (3.05 fold p=0.004) and tamoxifen response (3.90 fold; p=0.2514) in ER (+) BC cases. Although we suggest that modulation of miR-1266 expression may be an important mechanism underlying the chemoresistance of ER (+) BC, advanced studies and validation are required.

Evaluation of Genetic Variations in miRNA-Binding Sites of BRCA1 and BRCA2 Genes as Risk Factors for the Development of Early-Onset and/or Familial Breast Cancer

Erturk, Elif,Cecener, Gulsah,Polatkan, Volkan,Gokgoz, Sehsuvar,Egeli, Unal,Tunca, Berrin,Tezcan, Gulcin,Demirdogen, Elif,Ak, Secil,Tasdelen, Ismet Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Although genetic markers identifying women at an increased risk of developing breast cancer exist, the majority of inherited risk factors remain elusive. Mutations in the BRCA1/BRCA2 gene confer a substantial increase in breast cancer risk, yet routine clinical genetic screening is limited to the coding regions and intronexon boundaries, precluding the identification of mutations in noncoding and untranslated regions. Because 3' untranslated region (3'UTR) polymorphisms disrupting microRNA (miRNA) binding can be functional and can act as genetic markers of cancer risk, we aimed to determine genetic variation in the 3'UTR of BRCA1/BRCA2 in familial and early-onset breast cancer patients with and without mutations in the coding regions of BRCA1/BRCA2 and to identify specific 3'UTR variants that may be risk factors for cancer development. The 3'UTRs of the BRCA1 and BRCA2 genes were screened by heteroduplex analysis and DNA sequencing in 100 patients from 46 BRCA1/2 families, 54 non-BRCA1/2 families, and 47 geographically matched controls. Two polymorphisms were identified. SNPs $c.^*1287C$ >T (rs12516) (BRCA1) and $c.^*105A$ >C (rs15869) (BRCA2) were identified in 27% and 24% of patients, respectively. These 2 variants were also identified in controls with no family history of cancer (23.4% and 23.4%, respectively). In comparison to variations in the 3'UTR region of the BRCA1/2 genes and the BRCA1/2 mutational status in patients, there was a statistically significant relationship between the BRCA1 gene polymorphism $c.^*1287C$ >T (rs12516) and BRCA1 mutations (p=0.035) by Fisher's Exact Test. SNP $c.^*1287C$ >T (rs12516) of the BRCA1 gene may have potential use as a genetic marker of an increased risk of developing breast cancer and likely represents a non-coding sequence variation in BRCA1 that impacts BRCA1 function and leads to increased early-onset and/or familial breast cancer risk in the Turkish population.

Circulating miR-195 as a Therapeutic Biomarker in Turkish Breast Cancer Patients

Cecener, Gulsah,Ak, Secil,Eskiler, Gamze Guney,Demirdogen, Elif,Erturk, Elif,Gokgoz, Sehsuvar,Polatkan, Volkan,Egeli, Unal,Tunca, Berrin,Tezcan, Gulcin,Topal, Ugur,Tolunay, Sahsine,Tasdelen, Ismet Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

Background: Dysregulation of miRNA expression may be used as a biomarker for specific tumours because it may contribute to development of cancer. Circulating miRNA profiles have been highlighted for their potential as predictive markers in heterogeneous diseases such as breast cancer. In the literature, there is evidence that miR-195 levels are differentially expressed pre- and post-operative periods in breast cancer patients. At the same time, miRNA expression levels may vary because of ethnic origins. This study aimed to determine expression levels and potential roles of miR-195 in Turkish breast cancer patients. Materials and Methods: The expression patterns of miR-195 were initially examined in breast cancer tissues (luminal A and B type) (n=96). Subsequently, blood samples were prospectively collected from preoperative and postoperative Turkish breast cancer patients and disease free controls. Total RNA was isolated, and the expression level of miR-195 was quantified by real-time PCR. Results: We found that miR-195 level was altered in Turkish breast cancer patients, with down-regulation evident in breast cancer tissues compared to normal adjacent specimens. Furthermore, circulating levels of miR-195 was significantly decreased in post-operative blood samples compared with pre-operative levels (p=0.01 and <0.05). However, miR-195 was significantly increased in pre-operative blood samples of the luminal B type (p=0.04 and <0.05). Conclusions: This study represents the first report of a miR-195 expression profile in Turkish breast cancer patients. Our data suggests that miR-195 levels might be a clinically useful biomarker in the earliest stage of Turkish breast cancer patients.