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RISS 인기검색어
- 검색키워드
- 저자 : Tamar Perri (검색결과 2 건)
- 무료
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Risk Factors for Cervical Cancer and CIN3 in Jewish Women in Israel - Two Case Control Studies
Bassal, Ravit,Schejter, Eduardo,Bachar, Rachel,Perri, Tamar,Korach, Jacob,Jakobson-Setton, Ariella,Ben-David, Liat Hogen,Cohen, Daniel,Keinan-Boker, Lital Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Purpose: The aim of the study was to identify risk and protective factors/markers for cervical cancer and cervical intraepithelial neoplasia 3 (CIN3) in Israeli Jewish women in order to settle the discrepancy of low incidence rate of cervical cancer and relatively high incidence rate of CIN3. Materials and Methods: We conducted two case control studies, which examined the association between potential risk and protective factors/markers for cervical cancer or CIN3 using self administered detailed questionnaires. Results: For studying cervical cancer, 40 cases and 40 matched controls were interviewed. In the univariable and multivariable analyses older age, depression or anxiety and ever smoking seemed to act as independent risk factors/markers, while older age at first intercourse was protective. For studying CIN3, 99 cases and 79 controls were interviewed. Multivariable analysis has demonstrated that being born in Israel, depression or anxiety and ever smoking were independent risk factors/markers for CIN3. Conclusions: The risk factors/markers studied, that were associated with cervical cancer or CIN3 among Jewish women in Israel, are similar to those reported in other parts of the world, and do not explain the observed discrepancy of high in-situ cervical cancer rates and low invasive cervical cancer incidence in Israel.
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Limor Helpman,Omri Zidan,Eitan Friedman,Sarit Kalfon,Tamar Perri,Gilad Ben-Baruch,Jacob Korach 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5
Objective: The current study investigates disease patterns and outcomes in young Israeliepithelial ovarian cancer (EOC) patients and their association with BRCA mutation status. Methods: Consecutive EOC patients diagnosed at or below 50 years in a single institutionbetween 1995–2011 were identified. All patients are referred for genetic counseling andtesting for the predominant Jewish BRCA mutations: BRCA1-185delAG, BRCA1-5382insC,and BRCA2-6174delT. A comparison between BRCA mutation carriers and non-carriers wasundertaken across demographic, pathologic, and clinical features; recurrence and survivalwere compared using the Kaplan-Meier method and associations with the variables ofinterest ware analyzed using the Cox proportional hazards method. Results: One hundred eighty-six patients diagnosed with EOC at 50 years or younger wereincluded, with a total follow-up of 1,088 person years. Mean age at diagnosis was 44±5 years. Of 113 patients with documented BRCA testing, 49.6% carried a germline BRCA mutation,compared with 29% in the general Israeli EOC population (p=0.001). BRCA mutationcarriers had a higher rate of serous tumors (75% vs. 64%, p=0.040) and higher CA125 levelsat diagnosis (median, 401 vs. 157, p=0.001) than non-carriers. No significant associationbetween BRCA mutations and recurrence (hazard ratio [HR]=1.03; p=0.940) or survival(HR=1.40; p=0.390) was found. Conclusion: BRCA mutations are encountered in almost 50% of young Israeli ovarian cancerpatients; they are associated with serous tumors and high CA125 levels at diagnosis, but arenot independently associated with recurrence or survival in this patient population.
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