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- 저자 : Takahiro Nemoto (검색결과 2 건)
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Naohisa Tsujino,Takahiro Nemoto,Keiko Morita,Naoyuki Katagiri,Shinya Ito,Masafumi Mizuno 대한정신약물학회 2013 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.11 No.3
Objective: Interest in the “at-risk mental state” (ARMS) for psychosis has increased because early intervention is expected to delay or prevent the onset of schizophrenia. However, the optimum intervention strategy remains controversial, especially with regard to antipsychotics. Although administration of antipsychotic medications is often associated with adverse effects and raises ethical considerations, recent studies have shown that some novel antipsychotics are safer and more tolerable for young people than conventional antipsychotics. We investigated whether administration of perospirone, a combined serotonin (5-HT)/dopamine antagonist and 5-HT1A receptor agonist, could alleviate prodromal symptoms and be well tolerated by clinical high risk patients. Methods: The participants were outpatients seeking help. The Structured Interview for Prodromal Symptoms was performed in patients identified as being at clinical high risk. The Scale of Prodromal Symptoms (SOPS) was also completed and changes of subjective experience were assessed with the Subjective Well-being under Neuroleptics, short version. The incidence of akathisia was recorded by using the Barnse Akathisia Scale (BAS). Subjects were monitored for 26 weeks after starting medication. Results: SOPS scores improved significantly after 26 weeks of perospirone therapy, while BAS scores did not show deterioration. No serious adverse events occurred during the study. Conclusion: This trial suggests that perospirone therapy provides a clinical benefit for clinical high risk subjects without causing serious adverse events. Although further placebo-controlled studies are needed for confirmation, perospirone might be one of optimum treatments for individuals at imminent risk of psychosis.
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High-power Test of Annular-ring Coupled Structures for the J-PARC Linac Energy Upgrade
Jun Tamura,Hiroyuki Ao,Yasuo Nemoto,Hiroyuki Asano,Takahiro Suzuki 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.3
Annular-ring coupled structures (ACSs) will increase the beam energy of the Japan proton acceleratorresearch complex (J-PARC) linac from 181 to 400 MeV to achieve a beam power of 1MW for a materials and life science experimental facility. The mass production of the ACS cavitiescommenced in March 2009. Before the installation, all cavities require power testing. High-powertesting is essential not only for confirming the cavity’s design performance but also for preventingdelays in cavity conditioning schedule. However, the 2011 Tohoku earthquake damaged J-PARCfacilities, including the ACS power-test area, and cavity conditioning was interrupted for two years. After the facility’s restoration, two ACS cavities (M01 and M11) were conditioned. They performed15 − 20% above the designed accelerating field of 4.2 MV/m. As M01 was initially conditioned sixyears ago, the most recent conditioning time required for M01 was drastically reduced. From thisresult, we confirmed that long-term stored ACS cavities purged with nitrogen gas do not producecritical cavity performance issues. During high-power operation of M11, which is a unique cavityequipped with a capacitive iris in a waveguide, no significant increases in the temperature and thedischarge rate around the capacitive iris were observed. Even considering beam loss due to residualgas scattering, the vacuum pressure was sufficiently low (4 × 10−6 Pa). More stable operation canbe expected following a month-long conditioning process before the beam is commissioned. M11’sconditioning successfully demonstrated an auto-conditioning program, and we established the conditioningscheme using this auto-conditioning program for all ACS cavities in a limited time andwith limited manpower.
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