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        Repeated Administration of Fresh Garlic Increases Memory Retention in Rats

        Saida Haider,Nosheen Naz,Saima Khaliq,Tahira Perveen,Darakhshan J. Haleem 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.4

        Garlic (Allium sativum) is regarded as both a food and a medicinal herb. Increasing attention has focused on the biological functions and health benefits of garlic as a potentially major dietary component. Chronic garlic administration has been shown to enhance memory function. Evidence also shows that garlic administration in rats affects brain serotonin (5-hydroxytryptamine [5-HT]) levels. 5-HT, a neurotransmitter involved in a number of physiological functions, is also known to enhance cognitive performance. The present study was designed to investigate the probable neurochemical mechanism responsible for the enhancement of memory following garlic administration. Sixteen adult locally bred male albino Wistar rats were divided into control (n = 8) and test (n = 8) groups. The test group was orally administered 250 mg/kg fresh garlic homogenate (FGH), while control animals received an equal amount of water daily for 21 days. Estimation of plasma free and total tryptophan (TRP) and whole brain TRP, 5-HT, and 5-hydroxyindole acetic acid (5-HIAA) was determined by high-performance liquid chromatography with electrochemical detection. For assessment of memory, a step-through passive avoidance paradigm (electric shock avoidance) was used. The results showed that the levels of plasma free TRP significantly increased (P < .01) and plasma total TRP significantly decreased (P < .01) in garlic-treated rats. Brain TRP, 5-HT, and 5-HIAA levels were also significantly increased following garlic administration. A significant improvement in memory function was exhibited by garlic-treated rats in the passive avoidance test. Increased brain 5-HT levels were associated with improved cognitive performance. The present results, therefore, demonstrate that the memory-enhancing effect of garlic may be associated with increased brain 5-HT metabolism in rats. The results further support the use of garlic as a food supplement for the enhancement of memory.

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        Synthesis and characterization of graphene oxide, reduced graphene oxide and their nanocomposites with polyethylene oxide

        Alghyamah Abdulaziz A.,Haider Sajjad,Khalil Uzma,Khan Rawaiz,Haider Adnan,Almasry Waheed A.,Ihsan Rida,Tahira Perveen,Wazeer Irfan,Chafidz Achmad 한국물리학회 2022 Current Applied Physics Vol.40 No.-

        This work describes the synthesis of GO, rGO and their nanocomposites with PEO. GO and rGO were prepared by the modified Hummers method and in-situ reduction of GO utilizing green reductant L (+) Ascorbic acid. The nanocomposites were characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), Thermogravimetric Analysis (TGA), and Universal Testing Machine (UTM). FT-IR and XRD confirmed the synthesis of GO and rGO. FE-SEM confirmed the uniformly exfoliated GO and rGO nanosheets in the polymer matrix. Hydrogen bonding was the main interaction mechanism for GO with PEO while no interaction was detected by FT-IR for rGO. Enhanced thermal stability was observed for both GO/PEO and rGO/PEO nanocomposites. The mechanical analysis showed an increase in Young’s modulus, tensile strength, and elongation at break for GO/PEO nanocomposites, which is attributed to the homogeneous dispersion and hydrophilic hydrogen bonding interaction of GO with PEO.

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