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RISS 인기검색어
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- 저자 : T. Picker (검색결과 3 건)
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Deregulation of DNA Damage Signal Transduction by Herpesvirus Latency-Associated M2
Liang, Xiaozhen,Pickering, Mary T.,Cho, Nam-Hyuk,Chang, Heesoon,Volkert, Michael R.,Kowalik, Timothy F.,Jung, Jae U. American Society for Microbiology 2006 Journal of virology Vol.80 No.12
<B>ABSTRACT</B><P>Infected cells recognize viral replication as a DNA damage stress and elicit a DNA damage response that ultimately induces apoptosis as part of host immune surveillance. Here, we demonstrate a novel mechanism where the murine gamma herpesvirus 68 (γHV68) latency-associated, anti-interferon M2 protein inhibits DNA damage-induced apoptosis by interacting with the DDB1/COP9/cullin repair complex and the ATM DNA damage signal transducer. M2 expression constitutively induced DDB1 nuclear localization and ATM kinase activation in the absence of DNA damage. Activated ATM subsequently induced Chk activation and p53 phosphorylation and stabilization without eliciting H2AX phosphorylation and MRN recruitment to foci upon DNA damage. Consequently, M2 expression inhibited DNA repair, rendered cells resistant to DNA damage-induced apoptosis, and induced a G1 cell cycle arrest. Our results suggest that γHV68 M2 blocks apoptosis-mediated intracellular innate immunity, which might ultimately contribute to its role in latent infection.</P>
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Chip formation of rounded cutting edges
B. Bergmann,B. Denkena,T. Grove,T. Picker 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.1
In cutting processes, the performance and tool life of cutting tools are important evaluation criterions. The cutting edge microgeometry of the tools is in direct contact with the workpiece and thus influences the material flow and the loads on the cutting wedge. Research to date has demonstrated the potential of rounded cutting edges and their improved wear behavior. However, the investigations were always limited to a certain number of materials or processes. For a process-specific design of the cutting edge microgeometry, it must be possible to explicitly describe the material- and process-related contact conditions during machining with rounded cutting edges. Hence, the following article analyzes the chip formation of different cutting edge microgeometries during machining in continuous and interrupted cutting. For this purpose, planing tests on non-ferrous and ferrous materials as well as milling tests on steel alloys with differently rounded cutting tools are carried out and the effects on the chip formation process are analyzed. The results show that the minimum uncut chip thickness hmin correlates linearly to the cutting edge rounding. In addition, the correlation obtained is independent of the cutting process and the workpiece material.
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Understanding Himalayan erosion and the significance of the Nicobar Fan
McNeill, Lisa C.,Dugan, Brandon,Backman, Jan,Pickering, Kevin T.,Pouderoux, Hugo F.A.,Henstock, Timothy J.,Petronotis, Katerina E.,Carter, Andrew,Chemale Jr., Farid,Milliken Jr., Kitty L.,Kutterolf Jr Elsevier 2017 Earth and planetary science letters Vol.475 No.-
<P><B>Abstract</B></P> <P>A holistic view of the Bengal–Nicobar Fan system requires sampling the full sedimentary section of the Nicobar Fan, which was achieved for the first time by International Ocean Discovery Program (IODP) Expedition 362 west of North Sumatra. We identified a distinct rise in sediment accumulation rate (SAR) beginning ∼9.5 Ma and reaching 250–350 m/Myr in the 9.5–2 Ma interval, which equal or far exceed rates on the Bengal Fan at similar latitudes. This marked rise in SAR and a constant Himalayan-derived provenance necessitates a major restructuring of sediment routing in the Bengal–Nicobar submarine fan. This coincides with the inversion of the Eastern Himalayan Shillong Plateau and encroachment of the west-propagating Indo–Burmese wedge, which reduced continental accommodation space and increased sediment supply directly to the fan. Our results challenge a commonly held view that changes in sediment flux seen in the Bengal–Nicobar submarine fan were caused by discrete tectonic or climatic events acting on the Himalayan–Tibetan Plateau. Instead, an interplay of tectonic and climatic processes caused the fan system to develop by punctuated changes rather than gradual progradation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sediment accumulation rates in Nicobar Fan abruptly increase 9.5 Ma. </LI> <LI> Increased sediment flux to eastern Indian Ocean and restructuring of sediment routing. </LI> <LI> Nicobar Fan holds significant record of Indian Ocean sedimentation in late Neogene. </LI> <LI> Shillong Plateau and Indo–Burmese wedge uplift drive sediment south in late Miocene. </LI> </UL> </P>
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