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Kawai, Y,Osawa, T,Kobayashi, K,Inoue, R,Yamamoto, Y,Matsumoto, H,Nagao, K,Hara, T,Sakano, S,Nagamori, S,Matsuyama, H Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Background: Factors predictive of survival have been identified in Western patients with metastatic clear cell renal cell carcinoma (mCCRCC) treated with sunitinib. Less is known, however, about factors predictive of survival in Japanese patients. This study evaluated factors prognostic of survival in Japanese patients with mCCRCC treated with first-line sunitinib. Materials and Methods: This retrospective study evaluated 46 consecutive Japanese mCCRCC patients treated with sunitinib as first line therapy. Clinical and biochemical markers associated with progression-free survival (PFS) were analyzed, with prognostic factors selected by uniand multivariate Cox regression analyses. Results: Univariate analysis showed that factors significantly associated with poor PFS included Memorial Sloan-Kettering Cancer Center poor risk scores, International Metastatic RCC Database Consortium poor risk and high (>0.5 mg/dl) serum C-reactive protein (CRP) concentrations (p<0.001 each). Multivariate analysis showed that high serum CRP was independently associated with poorer PFS (p=0.040). Six month disease control rate (complete response, partial response and stable disease) in response to sunitinib was significantly higher in patients with normal (${\leq}0.5mg/dl$) than elevated baseline CRP (p<0.001). Conclusions: CRP is a significant independent predictor of PFS for Japanese patients with mCCRCC treated with first-line sunitinib. Pretreatment CRP concentration may be a useful biomarker predicting response to sunitinib treatment.
The Embedment of a Metadata System at Grid Farms at the Belle II Experiment
S. Ahn,J. H. Kim,T. Huh,S. Hwang,조기현,H. Jang,B. K. Kim,H. Yoon,J. Yu,Z. Drasal,T. Hara,Y. Iida,R. Itoh,G. Iwai,N. Katayama,Y. Kawai,S. Nishida,T. Sasaki,Y. Watase,T. Uglov,R. Fruhwirth 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.4
In order to search for new physics beyond the standard model, the next generation of B-factory experiment, Belle II will collect a huge data sample that is a challenge for computing systems. The Belle II experiment, which should commence data collection in 2015, expects data rates 50 times greater than that of Belle. In order to handle this amount of data, we need a new data handling system based on a new computing model, which is a distributed computing model including grid farms as opposed to the central computing model using clusters at the Belle experiment. We have constructed a metadata system and embedded the system in the grid farms of the Belle II experiment. We have tested the system using grid farms. Results show good performance in handling such a huge amount of data.
Status of JENDL High Energy File
Y. Watanabe,K. Kosako,S. Kunieda,S. Chiba,R. Fujimoto,H. Harada,M. Kawai,F. Maekawa,T. Murata,H. Nakashima,K. Niita,N. Shigyo,S. Shimakawa,N. Yamano,T. Fukahori 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The present status of the JENDL high-energy file is reported. The recent version (referred to as JENDL/HE-2007) contains neutron and proton cross section data for energies up to 3 GeV for 107 nuclides over the wide mass range from H to Am. The newly evaluated data for 41 nuclides have been added to the first version (JENDL/HE-2004) along with some revisions. The JENDL/HE-2007 includes neutron total cross sections, nucleon elastic scattering cross sections and angular distributions, nonelastic cross sections, production cross sections and double-differential cross sections of secondary light particles (n, p, d, t, ^3He, α, and π) and gamma-rays, isotope production cross sections, and fission cross sections in the ENDF-6 format. The evaluations were performed on the basis of experimental data, nuclear model calculations, and systematics based on measurements. The evaluated cross sections are compared with available experimental data and the other evaluations. Some results of benchmark tests with MCNPX codes are shown.