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RISS 인기검색어
- 검색키워드
- 저자 : Susan S. Percival (검색결과 4 건)
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Susan S. Percival,Meri P. Nantz,Cindy DeNiera,Kristen Green,Stephen T. Talcott,Cheryl A. Rowe 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.4
The phytochemical composition of passionfruit juice (PFJ) was hypothesized to have valuable anti-cancer ac-tivity, and this was tested in a BALB/c 3T3 neoplastic transformation model. A higher concentration of PFJ compared witha lower concentration was effective in reducing the number, size, and invasiveness of transformed foci. When incubated withanother mammalian cell line, the MOLT-4, PFJ was unable to alter the cell cycle kinetics while at the same time was suc-cessful in inducing the activity of caspase-3, an enzyme that commits the cell to apoptosis. This suggests that phytochemicalsfound in PFJ were able to produce the changes in transformed foci due to apoptotic mechanisms rather than by a reductionin cell proliferation. These beneficial results were achieved at levels that could theoretically be attained in the plasma afterconsumption of the juice.
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Chemopreventive Actions of Blond and Red-Fleshed Sweet Orange Juice on the Loucy Leukemia Cell Line
Dourado, Grace KZS,Stanilka, Joy M,Percival, Susan S,Cesar, Thais B Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
Background: Red-fleshed sweet orange juice (ROJ) comes from a new variety of citrus cultivated in Brazil that contains high levels of ${\beta}$-carotene and lycopene, and similar amounts of hesperidin (HSP) and nutrients, equivalently to blond orange juice (BOJ). Such bioactive compounds are associated with chemopreventive actions in several cancer cell lines. The purpose of this study was to examine the cytotoxicity, cell cycle, apoptosis, and cytokine secretion after BOJ, ROJ, and HSP treatment of a novel T acute lymphoblastic leukemia cell line, Loucy. Materials and Methods: Loucy cells were incubated for 24-h with BOJ, ROJ, and HSP, and the viability was measured using trypan blue. Cell cycling and apoptosis were assessed by propidium iodide (PI) and annexin V-FITC/PI flow cytometry, respectively. Secretion of cytokines $IL-1{\alpha}$, $IL1-{\beta}$, IL-2, IL-4, IL-6, IL-10, IL-17A, $IFN{\gamma}$, $TNF{\alpha}$, $TGF{\beta}$, $MIP{\alpha}$, and $MIP{\beta}$ was determined by ELISA array. Results: BOJ and ROJ treatments promoted Loucy cell cytotoxicity. Additionally, BOJ induced cell cycle arrest in the G0/G1 phase, and decreased the cell accumulation in the G2/M. ROJ decreased only the G0/G1 fraction, while HSP did not change the cell cycle. BOJ led to apoptosis in a different fashion of ROJ, while the first treatment induced apoptosis by increase of late apoptosis and primary necrotic fractions, the second increased early and late apoptosis, and primary necrotic fraction compared to positive controls. HSP had no effect on apoptosis. IL-6 and IL-10 were abrogated by all treatments. Conclusions: Taking together, these results suggest potential chemopreventive effects of BOJ and ROJ on Loucy cells.
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ular Consumption of Concord Grape Juice Benefits Human Immunity
Cheryl A. Rowe,Meri P. Nantz,Carmelo Nieves Jr.,Robin L. West,Susan S. Percival 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1
γδ T cells are important immune surveillance cells residing in epithelial layers lining the intestine, lung, and reproductive tract. The main objective of this study was to test the hypothesis that consumption of dietary compounds from grapes would modify γδ T-cell function. Other factors related to immune function after grape juice consumption were also tested. A randomized, double-blind, placebo-controlled, parallel intervention was conducted: 100% grape juice made from Concord grapes or a placebo beverage was consumed by 85 individuals daily for 9 weeks. Subjects were asked not to consume other red, blue, and purple fruits during the study. Blood samples, taken at the beginning and the end, were analyzed for γδ T-cell numbers and proliferation, vitamin C, antioxidant capacity, and the ability to protect DNA from strand breaks. Those consuming the grape juice had significantly greater numbers of circulating γδ T cells and higher serum vitamin C levels compared to the placebo by two-way repeated-measure analysis of variance (P<.05). Individuals consuming the placebo had lower serum antioxidant activity, less γδ T-cell proliferation, and increased DNA strand breaks when challenged with H2O2. Analysis of the data by structural equation modeling confirmed that 61% of the variance in biological functions at 9 weeks was due to grape juice consumption. Based on conventional statistical analyses, as well as on sophisticated modeling techniques, regular consumption of purple grape juice in the absence of other red, blue, or purple fruits benefited immunity in healthy, middle-aged human subjects.
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