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고연령층에서의 세포성면역의 변화에 관한 연구 - 비특이적 자극에 대한 T - 세포와 폐포대식세포의 반응을 중심으로 -
한성구(Sung Koo Han),이계영(Kye Young Lee),최형석(Hyung Seok Choi),정희순(Hee Soon Chung),김영환(Young Whan Kim),심영수(Young Soo Shim),김건열(Keun Youl Kim),한용철(Yong Chol Han) 대한내과학회 1994 대한내과학회지 Vol.46 No.6
Background: T-cells and macrophages are the two elements that play the key roles in cell-mediated immunity. Based on the evidences for the involution of thymus occuring as the age become older, the cell-mediated immunity is expected to be altered in geriatric population. Moreover, the T-cell proliferatve response to non-specific stimulants such as phytohemagglutinin (PHA) is known to be decreased in aged population. However, there has been no convincing evidences for the functional decline of macrophages in aged population. The alterations of immune system accompanied by the increase in age have the clinical significances in that the geriatric population is much more susceptible to the diseases such as infectious, neoplastic, and autoimmune diseases where the immune system is proved to play a great role in their pathogenesis. To evaluate the alteration of cell-mediated immunity in old age, we investigated the responses of T-cell and alveolar macrophages from healthy geriatric population, and compared them with those of the young control population. Method: To evaluate the alterations of T-cell function, lymphoblastogenesis in response to concanavalin-A (Con-A) and PHA was measured by 3H-thymidine incorporation method and high affinity IL-2 receptor expression (Tac antigen) after stimulation with PHA was measured by flow cytometry using peripheral blood mononuclear cells from young and old age group, respectively. To evaluate the alterations of macrophage function, superoxide anion productions by alveolar macrophages both in basal state and in response to phobol myristate acetate (PMA) were measured and the priming effect of interferon-gamma was also compared. Results: 1) The lymphoblastogenesis in response to Con-A and PHA was significantly depressed in old age group compared with young control group. 2) The expression of high affinity IL-2 receptor after stimulation with PHA was also significantly depressed in old age group. 3) There was no difference in the superoxide anion production by alveolar macrophages between old age group and young control group both in basal state and after PMA stimulation. 4) There was no priming effect of interferon-gamma pretreatment in both old age group and young control group. Conclusion: The functional defect of T-cells associated with aging is evident but that of alveolar macrophages is not conclusive. It is suggested that the alterations of T-cells play a more important role than macrophages in the depression of cell-mediated immunity accompanied by aging process than macrophages but there remain many palces of further investigation in the functional changes of macrophages associted with aging.
폐기능저하로 수술대상에서 제외된 비소세포성 폐암 환자의 분석
한성구(Sung Koo Han),이상도(Sang Do Lee),심영수(Young Soo Shim),김건열(Keun Youl Kim),한용철(Yong Chol Han) 대한내과학회 1988 대한내과학회지 Vol.34 No.6
N/A Early surgical resection of Non-small cell lung cancer is still the treatment of choice and this includes the AJC clinical stages of I & II. Among the 567cases of Non- small cell lung cancer which have been diagnosed at Seoul National University Hospital during the period of March 1984 to February 1987, 21 cases were found to be surgically resectable stage but inoperable due to poor pulmonary reserve, We analyzed these 21cases in special reference to their histologic type, stage at the time of initial diagnosis, causes of poor pulmonary function test, mean survival time of these category patients and the results are summarized as follows. 1) Of 21cases, histologic type of 20cases were squamous cell carcinoma (95%) and 1case was adenocarcinoma (5%). 2) Of 21cases, 19cases were in stage I (90%) and 2cases were in stage II (10%). 3) Analysis of causes of poor pulmonary function revealed chronic obstructive lung disease in 15cases (71%), pulmonary tuberculosis in 5cases (24%), severe pleural adhesion in 1case (5%). 4) Mean values of pulmonary function test were FVC 1.93±0.42 1. FEV1 1.08±0.31 1, and there was no difference in the pattern of pulmonary function test between pulmonary tuberculosis patients and COPD patients. 5) Mean values of arterial blood gas analysis were PaO2 74±11mmHg, PaCO2 39±6mmHg. 6) Mean survivals of patients who died are 15±10 months for patients who received radiation therapy, 12 months for patient who received anticancer chemotherapy, 3.5±0.5 months for patients who received no treatment.