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- 저자 : Sunanta, Naritsara (검색결과 3 건)
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Maneetong, Photcharaphan,Srisang, Chutikan,Sunanta, Naritsara,Muchalintamolee, Praeploy,Pearodwong, Pachara,Suwimonteerabutr, Junpen,Rensis, Fabio De,Tummaruk, Padet Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.5
Objective: Current study was conducted to determine the effect of postpartum prostaglandin F2α (PGF2α) administration on colostrum and milk yield, colostrum immunoglobulin G (IgG) and piglet growth performance. Methods: In total, 36 sows were included in the experiment. The sows were classified into two groups: i) control (n = 11) and ii) PGF2α (n = 25). Sows in the PGF2α group received 10 mg of PGF2α within an hour after farrowing. The body weight of piglets was measured at 0 and 24 h after birth to estimate colostrum consumption. Colostrum was collected at 1 and 24 h after farrowing to determine IgG concentrations. For milk yield study, the remaining sows in the PGF2α group (n = 23) were divided into two subgroups: i) single PGF2α (n = 12) and ii) multiple PGF2α (n = 11). In the multiple PGF2α, the sows received repeated doses of PGF2α at seven and 14 days postpartum. The piglets' body weight was measured at 0, 1, 5, and 20 days of age. The milk yield of the sows was calculated. Results: Colostrum yield of sows averaged 5.62±2.25 kg. Sows treated with PGF2α postpartum had a higher colostrum yield than control (7.01 and 5.12 kg, p<0.05). The concentration of IgG in colostrum at 24 h in the PGF2α group was higher than the control (31.6 and 17.4 g/L, p<0.05). For primiparous sows, milk yield was highest in the sows treated with multiple doses of PGF2α during lactation and lowest in control sows (10.25 and 7.61 kg, p<0.05). Colostrum intake was higher in the treatment than the control groups (+56.7 g, p<0.05). Primiparous sows treated with multiple doses of PGF2α had a higher litter weight than controls (p<0.01). Conclusion: Postpartum treatment with PGF2α improved colostrum yield and IgG in multiparous sows and increased colostrum intake of piglets. Multiple administration of PGF2α improved the milk yield and increased litter weight of piglets in primiparous sows.
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Hypermethylation of Suppressor of Cytokine Signaling 1 in Hepatocellular Carcinoma Patients
Saelee, Pensri,Chuensumran, Ubol,Wongkham, Sopit,Chariyalertsak, Sunanta,Tiwawech, Danai,Petmitr, Songsak Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Hepatocellular carcinoma (HCC), the most common primary hepatic tumor, is highly prevalent in the Asia-Pacific region, including Thailand. Many genetic and epigenetic alterations in HCC have been elucidated. The aim of this study was to determine whether aberrant methylation of the suppressor of cytokine signaling 1 gene (SOCS1) occurs in HCCs. Methylation specific-PCR assays were performed to identify the methylation status of SOCS1 in 29 tumors and their corresponding normal liver tissues. An abnormal methylation status was detected in 17 (59%), with a higher prevalence of aberrant SOCS1 methylation significantly correlating with HCC treated without chemotherapy (OR=0.04, 95%CI=0.01-0.31; P=0.001). This study suggests that epigenetic aberrant SOCS1 methylation may be a predictive marker for HCC patients.
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Antipsychotic Prescribing Pattern for Geriatric Patients with Delirium in Thailand
Pornjira Pariwatcharakul,Witchuda Chantarat,Supachoke Singhakant,Lalida Jantarak,Tidarat Suriyachaiwattana,Chanin Sakulisariyaporn,Nantawat Sitdhiraksa,Sunanta Chantakarn,Panom Ketumarn,Sornsiri Yanta 대한정신약물학회 2010 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.8 No.3
Objective: To describe the antipsychotic prescribing pattern for the treatment of delirium among hospitalized elderly patients when compared to those younger adults referred to a psychiatric consultation-liaison service in Thailand Methods: All psychiatric consultations performed upon hospitalized patients at a university hospital in Bangkok, Thailand, during a one-year period were reviewed. We collected the data from consultation request forms and medical records. Results: Among all 840 patients referred for psychiatric consultation, 656 of them had complete medical records available. The consultant psychiatrists diagnosed 172 (26.2%) of them with delirium. After excluding 16 patients with substance-withdrawal delirium,data on antipsychotics prescription of 156 (23.8%) patients were analyzed. The mean age was 61.3±17.6 years old (22-95);91 (61.9%) were 60 years old or more, and 103 (70.1%) were male. Antipsychotics were prescribed for 85.3% of all patients. Atypical antipsychotics were more commonly prescribed for the elderly (60 years or older) than for the young (51.6% vs 35.4%,p=0.038). Risperidone was the most frequently prescribed antipsychotic for elderly patients accounting for 44% of prescriptions. We found negative correlation between age of the patients and the dose of haloperidol; r=0.233, p=0.043. Conclusion: To our knowledge, this is the first study on current antipsychotics prescribing practice for the hospitalized elderly with delirium in a consultation-liaison service in Asia. Although the current evidence show no superiority for atypical antipsychotics over haloperidol, as well as limited evidence of their efficacy and safety in managing delirium, most doctors had the tendency to prescribe atypical antipsychotics for the hospitalized elderly patients with delirium. Further study is required to determine the optimal pharmacological therapies for delirium in the elderly.
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