Privacy- Preserving Keyword-based Semantic Search over Encrypted Cloud Data

Xingming Sun,Yanling Zhu,Zhihua Xia,Lihong Chen 보안공학연구지원센터 2014 International Journal of Security and Its Applicat Vol.8 No.3

Optical temperature sensing properties of Yb3+/Tm3+ co-doped NaLuF4 crystals

Lili Tong,Xiangping Li,Ruinian Hua,Lihong Cheng,Jiashi Sun,Jinsu Zhang,Sai Xu,Hui Zheng,Yanqiu Zhang,Baojiu Chen 한국물리학회 2017 Current Applied Physics Vol.17 No.7

Yb3þ/Tm3þ and Yb3þ/Er3þ co-doped NaLuF4 crystals were synthesized by a facile hydrothermal method. The optical temperature sensing properties of Tm3þ based upon its two thermally coupled energy levels 3F2, 3 and 3H4 were systematically investigated by means of fluorescence intensity ratio (FIR) technique. The 980 nm laser-induced thermal effect on Tm3þ doped NaLuF4 crystals was studied by using Er3þ doped sample as thermal probe. The temperature sensitivity of Tm3þ in NaLuF4: Yb3þ/Tm3þ crystals shows a nonlinear dependence on temperature, and the maximum value is about 0.00045 K『1 at 600 K. The accuracy and reliability of the optical thermometry based on Tm3þ in NaLuF4: Yb3þ/Tm3þ crystals has been checked by using Yb3þ/Er3þ co-doped sample as temperature sensing unit. The results demonstrate that NaLuF4: Yb3þ/Tm3þ crystals have good sensing stability and may have potential application for the optical thermometry.

Co-precipitation synthesis and characterization of Bi3+, Eu3+ co-doped nanocrystal Gd2WO6 phosphors.

Tian, Yue,Chen, Baojiu,Hua, Ruinian,Cheng, Lihong,Zhong, Haiyang,Sun, Jiashi,Wang, Bo,Wan, Jing,Lu, Weili,Jang, Kiwan American Scientific Publishers 2010 Journal of Nanoscience and Nanotechnology Vol.10 No.3

<P>Eu3+ single-doped and Bi3+/Eu3+ co-doped nanocrystal Gd2WO6 phosphors were successfully synthesized via a co-precipitation reaction. The structure and morphology of the phosphors were characterized by using X-ray powder diffraction (XRD) and field emission scanning electron microscopy (FE-SEM). The influence of Bi(3+)-doping concentration on the excitation and emission spectra was studied. It was found that the introduction of Bi3+ can greatly affect the charge transfer band and the luminescence intensity of Eu3+ but does not cause a change in the profile of emission spectra of Eu3+.</P>

Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment

Zheng Jun,Huang Ju,Zhang Liang,Wang Mengna,Xu Lihong,Dou Xiaoyun,Leng Xiaojing,Fang Mingxiao,Sun Yang,Wang Zhigang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Although programmed cell death protein 1 (PD-1)/ programmed cell death-ligand protein 1 (PD-L1) checkpoint blockade immunotherapy demonstrates great promise in cancer treatment, poor infiltration of T cells resulted from tumor immunosuppressive microenvironment (TIME) and insufficient accumulation of anti-PD-L1 (αPD-L1) in tumor sites diminish the immune response. Herein, we reported a drug-loaded microbubble delivery system to overcome these obstacles and enhance PD-L1 blockade immunotherapy.Docetaxel (DTX) and imiquimod (R837)-loaded microbubbles (RD@MBs) were synthesized via a typical rotary evaporation method combined with mechanical oscillation. The targeted release of drugs was achieved by using the directional "bursting" capability of ultrasound-targeted microbubble destruction (UTMD) technology. The antitumor immune response by RD@MBs combining αPD-L1 were evaluated on 4T1 and CT26 tumor models.The dying tumor cells induced by DTX release tumor-associated antigens (TAAs), together with R837, promoted the activation, proliferation and recruitment of T cells. Besides, UTMD technology and DTX enhanced the accumulation of αPD-L1 in tumor sites. Moreover, RD@MBs remolded TIME, including the polarization of M2-phenotype tumor-associated macrophages (TAMs) to M1-phenotype, and reduction of myeloid-derived suppressor cells (MDSCs). The RD@MBs + αPD-L1 synergistic therapy not only effectively inhibited the growth of primary tumors, but also significantly inhibited the mimic distant tumors as well as lung metastases.PD-L1 blockade immunotherapy was enhanced by RD@MBs delivery system.

Modularized bioceramic scaffold/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs

Yingming Wei,Zhongxiu Wang,Jiayin Han,Xiaojian Jiang,Lihong Lei,Xianyan Yang,Weilian Sun,Zhongru Gou,Lili Chen 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: Destruction of alveolar bone and periodontal ligament due to periodontal disease often requires surgical treatment to reconstruct the biological construction and functions of periodontium. Despite significant advances in dental implants in the past two decades, it remains a major challenge to adapt bone grafts and barrier membrane in surgery due to the complicated anatomy of tooth and defect contours. Herein, we developed a novel biphasic hierarchical architecture with modularized functions and shape based on alveolar bone anatomy to achieve the ideal outcomes. Methods: The integrated hierarchical architecture comprising of nonstoichiometric wollastonite (nCSi) scaffolds and gelatin methacrylate/silanized hydroxypropyl methylcellulose (GelMA/Si-HPMC) hydrogel membrane was fabricated by digital light processing (DLP) and photo-crosslinked hydrogel injection technique respectively. The rheological parameters, mechanical properties and degradation rates of composite hydrogels were investigated. L-929 cells were cultured on the hydrogel samples to evaluate biocompatibility and cell barrier effect. Cell scratch assay, alkaline phosphatase (ALP) staining, and alizarin red (AR) staining were used to reveal the migration and osteogenic ability of hydrogel membrane based on mouse mandible-derived osteoblasts (MOBs). Subsequently, a critical-size one-wall periodontal defect model in dogs was prepared to evaluate the periodontal tissue reconstruction potential of the biphasic hierarchical architecture. Results: The personalized hydrogel membrane integrating tightly with the nCSi scaffolds exhibited favorable cell viability and osteogenic ability in vitro, while the scratch assay showed that osteoblast migration was drastically correlated with Si-HPMC content in the composite hydrogel. The equivalent composite hydrogel has proven good physiochemical properties, and its membrane exhibited potent occlusive effect in vivo; meanwhile, the hierarchical architectures exerted a strong periodontal regeneration capability in the periodontal intrabony defect models of dogs. Histological examination showed effective bone and periodontal ligament regeneration in the biomimetic architecture system; however, soft tissue invasion was observed in the control group. Conclusions: Our results suggested that such modularized hierarchical architectures have excellent potential as a next-generation oral implants, and this precisely tuned guided tissue regeneration route offer an opportunity for improving periodontal damage reconstruction and reducing operation sensitivity.

Metabolism Characteristics of Mycoplasma pneumoniae Infection in Asthmatic Children

Luo Jiaying,Chen Huian,Zhang Qiyong,Huang Xinyun,Qin Xu,Li Jing,Chen Siyi,Xiao Yongxin,Sun Lihong,Sun Baoqing 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.6

Purpose: Studies have shown that Mycoplasma pneumoniae (Mp) infection can aggravate symptoms in asthmatics. However, the mechanism by which Mp infection exacerbates asthma remains unclear. Metabolomics can help identify the mechanism of Mp aggravating asthma in children, thereby providing more a potential target for improving clinical treatment programs. In this article, we analyzed the metabolic level of patients to explain how Mp aggravates asthma in children. Methods: We divided the subjects into the asthma, Mp infection, asthma combined with Mp infection and healthy groups. Patients’ peripheral blood was collected for metabolic and interaction analysis. Cytokine levels were measured via serum and exhaled breath condensate (EBC). Results: A total of 150 participating subjects were divided into four groups after exclusion. We found out that there were different metabolic pathways between the healthy and disease groups. The major pathways of both asthma and asthma combined with Mp infection were valine, leucine and isoleucine biosynthesis; malate-aspartate shuttle was the main differential pathway for Mp infection. Moreover, even though three disease groups involved 81 metabolites at the same time, compared with asthma combined with Mp infection, 2 single disease groups still involved different amino acid pathways (phenylalanine, tyrosine and tryptophan biosynthesis; valine, leucine and isoleucine biosynthesis). Interaction analysis showed that Mp infection in asthmatic patients not only activated cytokines, but also activated Toll-like receptors (TLRs) 2 and 6. Finally, the levels of interleukin (IL)-4, IL-8, IL-13 and tumor necrosis factor-α in EBC with asthma combined with Mp infection were significantly higher than the 2 single disease groups. Conclusions: Mp infection in asthmatic children can cause changes in the levels of various amino acids in the body, which were enriched in the pathways such as valine, leucine and isoleucine biosynthesis. Palmitic acid can activate TLR2, and iloprost reduces IL-10 levels, ultimately leading to the increased airway inflammation.

工程教育认证视域下新能源专业劳动教育协同育人解析

李治宇(Zhiyu Li),王文文(Wenwen Wang),张玉春(Yuchun Zhang),闫洪波(Hongbo Yan),王丽红(Lihong Wang),孙焱(Yan Sun),付鹏(Peng Fu) YIXIN 출판사 2024 Journal of Humanities and Social Sciences Vol.2 No.2

在全球能源转型与环境保护的大背景下,新能源专业的人才培养显得尤为重要。工程教育认证视角下新能源专业劳动教育协同育人模式,以储能原理与技术课程为例,提出了一个创新的教学方案。本研究围绕工程教育认证的核心要求,探索了将劳动教育融入专业学习的具体实践路径,旨在提升学生的实践能力、创新能力和社会责任感。通过实验、项目驱动学习、企业实习等方式,强化理论与实践的结合,促进学生能力的全面发展。研究结果表明,该协同育人模式能有效地提升学生的专业技能和工程素养,为新能源领域培养出更具实践经验和创新能力的高质量人才。本研究不仅对新能源专业教育具有重要的指导意义,也为其他工程专业的人才培养提供了可借鉴的经验。 In the context of global energy transformation and environmental protection, talent cultivation in the field of new energy is particularly important. A collaborative education model for labor education in the field of new energy from the perspective of engineering education professional certification, taking the Energy Storage Principles and Technology course as an example, proposes an innovative teaching plan. This study focuses on the core requirements of engineering education professional certification and explores specific practical paths for integrating labor education into professional learning, aiming to enhance students’ practical ability, innovation ability, and social responsibility. By conducting experiments, project-driven learning, and enterprise internships, we aim to strengthen the integration of theory and practice and promote the comprehensive development of student abilities. The research results indicate that this collaborative education model can effectively enhance students' professional skills and engineering literacy and cultivate high-quality talent with more practical experience and innovative abilities in the field of new energy. This study not only has important guiding significance for the education of new energy majors but also provides valuable experience for talent cultivation in other engineering majors.