http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Optimization of Hypoxia Degradation Albumin Based Nanoparticle
Suheon KIM,Hoomin LEE,Kwanwoo KIM,Eunsu KIM,Yun Suk HUH 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
In tumor tissue, hypoxia appears due to abnormal growth and metabolism of cancer cells and disorganized vasculature. In hypoxic tumor, it is difficult for chemo drug to penetrate the tumor and reduces the effectiveness of therapeutic effect. We synthesized bovine serum albumin (BSA)-based nanoparticles (BSA NP) that can be degraded using by azobenzene, which reacts sensitive in the hypoxic environment of tumors. The optimal form of BSA NPs was synthesized by adding the amount of azobenzene, a crosslinker. BSA NPs have a size of around 100 ㎚ in a normoxia condition, and are decomposed and reduced in size in a hypoxic condition due to the cleavage of azobenzene. BSA NPs are especially decomposed in a hypoxic environment and can serve as an effective drug carrier in tumor tissue.
Eunsu KIM,Hoomin LEE,Kwanwoo KIM,Suheon KIM,Yun Suk HUH 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Calcium phosphate-based nanoparticles (CaP-NPs) are in demand as carriers in the drug delivery field because of their reactivity to pH and high biocompatibility. Plus, we devised a strategy that is specific to cancer cells and can reach combinational anticancer therapy through photothermal therapy by using conjugate linking BSA/gold nanocluster (BSA-Au NCs), cathepsin B cleavable peptide, GGRRG, and Doxorubicin for CaP nanoparticle synthesis. This BSA-Au NCs/GGRRG/DOX CaP-NPs showed marked cytotoxicity in tumor cells overexpressing cathepsin B enzyme, while less toxicity in normal cells with little cathepsin B expression. Moreover, it shows a higher drug release rate at an acidic pH of 5.0, allowing the drug to quickly reach endosomal escape. These nanoparticles were found to have excellent hyperthermal effects in response to near-infrared laser irradiation (808 ㎚). Our results demonstrated that the designed nanoparticles exhibit successful tumor-targeting ability and both chemo-photothermal therapy are applied to have a strong anticancer effect.
Electrical Characteristics of the Backgated Bottom-Up Silicon Nanowire FETs
DukSoo Kim,YoungChai Jung,MiYoung Park,ByungSung Kim,SuHeon Hong,MinSu Choi,MyungGil Kang,YunSeop Yu,Dongmok Whang,SungWoo Hwang IEEE 2008 IEEE TRANSACTIONS ON NANOTECHNOLOGY Vol.7 No.6
<P>We report the electrical characteristics of backgated silicon nanowire (SiNW) FETs at temperatures ranging from 300 to 160 K. The voltage drop along the intrinsic part of the silicon nanowire (SiNW) was obtained by modeling the source/drain contacts as Schottky diodes. The field effect mobility values obtained from the extracted intrinsic voltage drop showed activation behaviors in the given temperature range. The activation energy was smaller than that of previously reported Ge nanowires.</P>