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Effects of cocaine on cannabinoid receptor 1 availability in acute brain slice of marmoset
Sowoon Seo,Hyun Kyu Min,Dohyun Lee,Jae Jun Lee,Heejong Eom,Seong Shoon Yoon,Jaesuk Yun 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Endogenous cannabinoid system is closely associated with cocaine action in brain. However, CB1 availability in cocaine treated non human primate’s brain is not well known. In this study, we studied CB1 binding intensity by using a fluorescent cannabinoid ligand, T1117 in acute brain slice of common marmoset (Callithrix jacchus). Moreover, CB1 expression levels and dopamine concentration of slice bath media was measured. Cocaine treatment increased fluorescence intensity of T1117 in dorsal striatum (caudate and putamen) and nucleus accumbens (Nacc) of marmoset. We demonstrated that upregulated CB1 protein expression is associated with increase of CB1 ligand binding in the brain reward region. We will further discuss a possible role of CB1 in cocaine action on dopamine neurotransmission in meeting. Acknowledgement This research was supported by a grant (20182MFDS425) from Ministry of Food and Drug safety in 2020