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원전 생애주기 정보 관리를 위한 원자력 발전소 분류체계 및 국제 표준 기반 참조 데이터 라이브러리의 구축에 관한 연구
권순조(Soonjo Kwon),이승훈(Seunghoon Lee),이한라(Hanra Lee),류동수(Dongsu Ryu),한순흥(중앙연구원) (사)한국CDE학회 2014 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2014 No.2
All life cycle stages of a nuclear power plant can be divided into project planning, design, procurement, construction, and operation & maintenance. At each stage, various types of information is created and handed over to the next stage, and information loss occurs frequently in this hand-over process. It results in additional work and cost in the O&M stage because of the absence of information received from previous stages. Therefore, it is required to manage all the life cycle information without any loss and utilize it effectively in O&M stage. In this study, a plant breakdown structure and a way to build up reference data library based on international standards are proposed to manage all the life cycle information of nuclear power plant efficiently
Minseon LEE,Soonjo KWON 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Natural killer (NK) cells are responsible for the effector function against tumors in innate immune system, predominantly mediated by the secretion of lytic granules containing granzyme and perforin at immunological synapses. However, strategies for NK cell-immunotherapy still should be developed due to the existing immune evasion of tumors by protecting cells from granule uptake and being resistant to NK cell-mediated killing. In this study, we designed a direct current electrical stimulation (ES) system using platinum electrodes as a strategy for enhancing cytotoxic activity and half-life of NK cells for efficient immunotherapy. ES effects have been studied in tissue engineering for bone healing and stem cells by targeting calcium signaling on cell differentiation and migration. Exposure to electrical field could induce changes in calcium flux and mediated pathway, which could be also indispensable for exocytosis of cytotoxic enzyme and tumor killing in NK cells. Cultured KHYG-1 cells were exposed to 1hr direct current ES (voltage range from 0.2 to 1.0V/㎝) and effect of stimulation was analyzed by cell viability, NK cell-mediated cytotoxicity, and gene expression level of related genes. Gene expression level of GZMB was 1.36-fold and 1.58-fold higher without any effects on cell viability, following exposure to ES with 0.5V/cm and 1.0V/㎝, respectively. These findings provide the useful insight regarding the strategies for improving NK cell-mediated cytotoxicity through calcium-dependent exocytosis of lytic granules without any genetic modification, which need to be further studied as one of the new immunotherapy methods.