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Song Yeon-Hwa,Park Se-Ah,Yun Su-Jin,Yang Hye-Jin,Yoon A-Young,Kim Haek-Won 한국발생생물학회 2011 발생과 생식 Vol.15 No.4
Human eyelid adipose-derived stem cells (hEAs) and amniotic mesenchymal stem cells (hAMs) are very valuable sources for the cell therapeutics. Both types of cells have a great proliferating ability in vitro and a multipotency to differentiate into adipocytes, osteoblasts and chondrocytes. In the present study, we evaluated their stem cell characteristics after long-time cryopreservation for 6, 12 and 24 months. When frozen-thawed cells were cultivated in vitro, their cumulative cell number and doubling time were similar to freshly prepared cells. Also they expressed stem cell-related genes of SCF, NANOG, OCT4, and TERT, ectoderm-related genes of NCAM and FGF5, mesoderm/endoderm-related genes of CK18 and VIM, and immune-related genes of HLA-ABC and 2M. Following differentiation culture in appropriate culture media for 2-3 weeks, both types of cells exhibited well differentiation into adipocyte, osteoblast, and chondrocyte, as revealed by adipogenic, osteogenic or chondrogenic-specific staining and related genes, respectively. In conclusion, even after long-term storage hEAs and hAMs could maintain their stem cell characteristics, suggesting that they might be suitable for clinical application based on stem cell therapy.
Efficacy of an Injectable Thermosensitive Gel on Postoperative Adhesion in Rat Model
Hye Seong Ahn,Hyuk-Joon Lee,Moon-Won Yoo,Sang-Ho Jeong,Tae-Su Han,Woo-Ho Kim,Soo-Chang Song,Han-Kwang Yang 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.4
Purpose: For easy application to targeted area or in laparoscopic surgery, proper injectable antiadhesive agents are needed. The efficacy of two injectable antiadhesive agents- the thermosensitive poly (organophosphazene) hydrogel (Gel group) and a mixed solution of hyaluronate and carboxymethyl cellulose (Guardix-sol<SUP>ⓡ</SUP>, Hanmi Medicare, Korea; Gd group) were compared with that of a positive control (one established membranous agent [Interceed<SUP>ⓡ</SUP>, Johnson & Johnson, USA; IC group]) and negative control (phosphate buffered saline, control group). Methods: Eight ischemic buttons were created on both sides of the peritoneum in twenty-four male Sprague Dawley rats. Each of the solutions, or membrane agent was applied before closing of the wound according to groups (six rats per group). Two rats in the IC group were excluded because of death or intraoperative bleeding. Animals were sacrificed at two or four weeks after surgery. The number of adhesion-forming ischemic buttons and the weight gain were analyzed. Results: The overall number of adhered ischemic buttons were 23 in the control group (n=48), 22 in the Gd group (n=48), 14 in the Gel group (n=48) and 0 in the IC group (n=32). Overall number of adhered ischemic buttons of the Gd group was not significantly different from that of the control group (P=1.000). However that of the Gel group was smaller than that of the control group, although not statistically significant (P=0.093). Conclusion: The Gel group demonstrated some possibility of having an antiadhesive effect, and the Gd group failed to show antiadhesive effect, in contrast to IC group. A large-scale preclinical study is required to verify these findings.
Effects of Electric Stimulation with Static Stretching on Hamstrings Flexibility
( Won-min Song ),( Hye-jeong Seo ),( Won-seob Shin ) 대한물리치료학회 2015 대한물리치료학회지 Vol.27 No.3
Purpose: Flexibility has been considered one of the most important goals in rehabilitation. This study aimed to investigate the effect of transcutaneous electrical nerve stimulation (TENS) with the static stretching technique on the flexibility of hamstrings. Methods: Twenty-four subjects (15 men, 9 women) with limited hamstrings flexibility received three different intervention sessions in random order. The treatment sessions included static stretching (SS), static stretching with motor-level TENS (SS with motor TENS) and sensory-level TENS (SS with sensory TENS). All sessions of SS were performed in the straight-leg raise position for 30 seconds followed by rest for 15 seconds, in repetitions for 10 minutes using a belt. The TENS groups underwent TENS stimulation (40 μs, 100 Hz) during the stretching for 10 minutes. Outcome measures were evaluated according to active knee extension (AKE) and recorded before the session and at 0, 3, 6, 9, and 15 minutes after the session. Results: There was significant improvement in hamstrings flexibility within all groups (p<0.05). SS with TENS (both sensory and motor) maintained significant increases in knee extension range of motion until 15 minutes post-treatment. In contrast, the SS-only group maintained significantly increased hamstrings flexibility only until 6 minutes post-treatment (p<0.05). Conclusion: Improvement in hamstrings flexibility with SS with TENS was maintained longer than with SS-only intervention. Electrical stimulation with stretching may be more effective than SS alone for increased duration of maintained hamstrings flexibility.
Song, Mi Young,Kang, Seok Yong,Kang, Anna,Hwang, Ji Hye,Park, Yong-Ki,Jung, Hyo Won Institute for Advanced Research in Asian Science a 2017 The American journal of Chinese medicine Vol. No.
<P>The cortex of <I>Cinnamomum</I><I>cassia</I> Presl (Cinnamomi Cortex: CC) has commonly been used for weight control in traditional medicines, but without a scientific basis. Therefore, this study was undertaken to investigate the anti-obesity effect of CC extract in a high-fat diet (HFD)-induced obese mouse model and in C2C12 mouse skeletal muscle cells. Male C57BL/6 mice were fed a normal diet or a HFD for 16 consecutive weeks, and orally administered CC extract (100 or 300<TEX>$ \,$</TEX>mg/kg) or metformin (250<TEX>$ \,$</TEX>mg/kg; positive control) daily for 16 weeks. CC extract administration significantly decreased body weights, food intakes, and serum levels of glucose, insulin, total cholesterol and ALT levels, prevented oral glucose tolerance and insulin resistance, inhibited the protein expressions of MyHC and PGC1<TEX>$ \alpha $</TEX> and the phosphorylation of AMPK, suppressed lipid accumulation in liver, decreased adipocyte size and increased muscle mass in obese mice. For this <I>in vitro</I> study, C2C12 myoblasts were differentiated into the myotubes for five days, and then treated with CC extract (0.1 or 0.2<TEX>$ \,$</TEX>mg/ml) for 24<TEX>$ \,$</TEX>h. CC extract significantly increased ATP levels by increasing the mRNA expressions of mitochondrial biogenesis-related factors, such as, PGC1<TEX>$ \alpha $</TEX>, NRF-1, and Tfam, and the phosphorylations of AMPK and ACC. Our results suggest CC extract controls weight gain in obese mice by inhibiting lipid accumulation and increasing energy expenditure, and that its action mechanism involves the up-regulation of mitochondrial biogenesis in skeletal muscle cells.</P>
( Hye Kyung Song ),( Ki Nam Shim ),( Hye Won Yun ),( Chung Hyun Tae ),( Chang Mo Moon ),( Seong Eun Kim ),( Hye Kyung Jung ),( Tae Hun Kim ),( Sung Ae Jung ),( Kwon Yoo ),( Il Hwan Moon ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Caustic ingestion can cause severe injury to upper gastrointestinal track. There were a few studies about clinical characteristics and treatments of caustic injury in Korea. We investigated the changes of caustic injury over 20 years in clinical characteristics including the pattern of endoscopic mucosal injury and the modality of treatments. Methods: This study was a retrospective review of medical records from patients with caustic injury from September 1993 through December 2012. Patients with caustic injury who visited hospital from 1993 to 2002 were classifi ed as early period group and patients with caustic injury who visited from 2003 to 2012 were classifi ed as late period group. Results: A total 140 patients (mean age 44±17 yrs, male 41.7%) were included [early period group (n= 50) vs. late period group (n= 90)]. Annual incidence of caustic ingestion did not decrease (range 2-20) over 20 years. Ingestion of alkali agents increased (10% vs. 57%, p<0.0001) and more than grade 2B of mucosal injury decreased (47.8% vs. 27.3%, p=0.0015) in late period group. There was no difference between two groups in sex, age, proportion of accidental ingestion, systemic and GI complication. Use of gastric lavage, NPO and broad spectrum antibiotics decreased in late period group (p<0.01). However, there was no difference in use of steroid between two groups (p=0.172). Conclusions: There was no decreasing trend in caustic ingestion and ingestion of alkali agents increased over the past 20 years. The tighter legislation on caustic agents is required and we need to be alert to the best management of caustic injury.
( Won Jun Song ),( Jung Seop Eom ),( Hong Seok Yoo ),( Byeong Ho Jeong ),( Ho Yun Lee ),( Won Jung Koh ),( Kyeong Man Jeon ),( Hye Yun Park ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder, various factors could be associated with the severity of pneumonia in patients with COPD. Therefore, we examined the risk factors associated with severe pneumonia in a COPD population. Methods: A retrospective observational study with a prospectively collected database of community-acquired pneumonia (CAP) was conducted between 2008 and 2012. Patients with hospital-acquired pneumonia, immunocompromised patients, and those without a baseline computed tomography (CT) scan were excluded. As a result, 150 patients with COPD and CAP were included. Results: Of the 150 patients, 106 (70.7%) and 44 (29.3%) were classified with non-severe and severe pneumonia, respectively. A multivariate logistic regression analysis revealed that the presence of pulmonary emphysema on a CT scan (odds ratio, 2.933; 95% confi dence interval, 1.144 7.516; P = 0.025) was independently associated with severe pneumonia in patients with COPD. However, no signifi cant difference in severity of the air ow limitation, presence of bronchiectasis, previous COPD medicationincluding inhaled corticosteroids, or pathogens was identifi ed between those with non-severe and severe pneumonia. Conclusions: The presence of pulmonary emphysema on a CT scan at the time of admission to the hospital of a patient with COPD was independently associated with severe pneumonia in a COPD population.