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RISS 인기검색어
- 검색키워드
- 저자 : Soltes, Glenn (검색결과 5 건)
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On the influence of vector design on antibody phage display
Soltes, Glenn,Hust, Michael,Ng, Kitty K.Y.,Bansal, Aasthaa,Field, Johnathan,Stewart, Donald I.H.,Dü,bel, Stefan,Cha, Sanghoon,Wiersma, Erik J. Elsevier 2007 Journal of biotechnology Vol.127 No.4
<P><B>Abstract</B></P><P>Phage display technology is an established technology particularly useful for the generation of monoclonal antibodies (mAbs). The isolation of phagemid-encoded mAb fragments depends on several features of a phage preparation. The aims of this study were to optimize phage display vectors, and to ascertain if different virion features can be optimized independently of each other.</P><P>Comparisons were made between phagemid virions assembled by g3p-deficient helper phage, Hyperphage, Ex-phage or Phaberge, or corresponding g3p-sufficient helper phage, M13K07. All g3p-deficient helper phage provided a similar level of antibody display, significantly higher than that of M13K07. Hyperphage packaged virions at least 100-fold more efficiently than did Ex-phage or Phaberge. Phaberge's packaging efficiency improved by using a SupE strain.</P><P>Different phagemids were also compared. Removal of a 56 base pair fragment from the promoter region resulted in increased display level and increased virion production. This critical fragment encodes a lacZ′-like peptide and is also present in other commonly used phagemids.</P><P>Increasing display level did not show statistical correlation with phage production, phage infectivity or bacterial growth rate. However, phage production was positively correlated to phage infectivity.</P><P>In summary, this study demonstrates simultaneously optimization of multiple and independent features of importance for phage selection.</P>
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Comprehensive validation of silicon cross sections
Czakoj, Tomas,Kostal, Michal,Simon, Jan,Soltes, Jaroslav,Marecek, Martin,Capote, Roberto Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.12
Silicon, especially silicon in the form of SiO<sub>2</sub>, is a major component of rocks. Final spent fuel storages, which are being designed, are located in suitable rock formations in the Earth's crust. Reduction of the uncertainty of silicon neutron scattering and capture is needed; improved silicon evaluations have been recently produced by the ORNL/IAEA collaboration within the INDEN project. This paper deals with the nuclear data validation of that evaluation performed at the LR-0 reactor by means of critical experiments and measurement of reaction rates. Large amounts of silicon were used both as pure crystalline silicon and SiO<sub>2</sub> sand. The critical moderator level was measured for various core configurations. Reaction rates were determined in the largest core configuration. Simulations of the experimental setup were performed using the MCNP6.2 code. The obtained results show the improvement in silicon cross-sections in the INDEN evaluations compared to existing evaluations in major libraries. The new Thermal Scattering Law for SiO<sub>2</sub> published in ENDF/B-VIII.0 additionally reduces the discrepancy between calculation and experiments. However, an unphysical peak is visible in the neutron spectrum in SiO<sub>2</sub> obtained by calculation with the new Thermal Scattering Law.
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Kovács Solt,Li Housen,Bühlmann Peter 한국통계학회 2020 Journal of the Korean Statistical Society Vol.49 No.4
In this discussion, we compare the choice of seeded intervals and that of random intervals for change point segmentation from practical, statistical and computational perspectives. Furthermore, we investigate a novel estimator of the noise level, which improves many existing model selection procedures (including the steepest drop to low levels), particularly for challenging frequent change point scenarios with low signal-to-noise ratios.
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A GENERALIZATION OF HOMOLOGICAL ALGEBRA
Davvaz, B.,Shabani-Solt, H. Korean Mathematical Society 2002 대한수학회지 Vol.39 No.6
Our aim in this paper is to introduce a generalization of some notions in homological algebra. We define the concepts of chain U-complex, U-homology, chain (U, U')-map, chain (U, U')-homotopy and $\mu$-functor. We also obtain some interesting results. We use these results to find a generalization of Lambek Lemma, Snake Lemma, Connecting Homomorphism and Exact Triangle.
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A generalization of homological algebra
B. Davvaz,H. Shabani-Solt 대한수학회 2002 대한수학회지 Vol.39 No.6
Our aim in this paper is to introduce a generalization of somenotions in homological algebra. We define the concepts of chainU-complex, U-homology, chain (U,U')-map, chain(U,U')-homotopy and mathcal U-functor. We also obtain someinteresting results. We use these results to find a generalizationof Lambek Lemma, Snake Lemma, Connecting Homomorphism and ExactTriangle.
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