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68Ga-DOTA-RGD2 Uptake in Plantar Fasciitis: New Insights into its Pathogenesis
Piyush Aggarwal,Singh Harmandeep,Kumar Rajender,Aman Sharma 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.3
Plantar fasciitis is chronic degenerative tendinopathy of the plantar fascia. Although it has many treatment modalities, none has been very effective due to the largely unknown pathogenesis of this condition. 68Ga-DOTA-RGD2 has an upcoming role in assessing disease activity and treatment response in rheumatoid arthritis. In the present case, we demonstrate the potential role of angiogenesis imaging in understanding the pathogenesis of plantar fasciitis and provide new opportunities for novel imaging options.
Jain Tarun Kumar,Singh Harmandeep,Kumar Rajender,Bal Amanjit,Sood Ashwani,Mittal Bhagwant Rai 대한핵의학회 2020 핵의학 분자영상 Vol.54 No.5
Pulmonary blastoma (PB) is a rare thoracic malignancy and preoperative diagnosis is challenging. A young man presented with dyspnea and chest pain for 3–4 months and chest-computed tomography (CT) revealed large mass in the left lung upper lobe and pleural effusion. Repeated CT-guided fine-needle aspiration cytology from the lesion and pleural fluid aspiration was negative for malignancy. F-18-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) revealed heterogeneous tracer avidity in left lung mass with areas of necrosis. Real-time PET-CT-guided biopsy from metabolically active component of the lesion revealed biphasic PB on histopathology.
68Ga-PSMA-11 uptake in tracheal mucus plug – a potential pitfall
Kunal Ramesh Chandekar,Apurva Sood,Kumar Rajender,Singh Harmandeep,Shrawan Kumar Singh 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.1
Prostate-specific membrane antigen (PSMA) PET/CT is a well-acclaimed imaging modality for prostate cancer (PCa). However, many reports have highlighted PSMA radioligand uptake in a variety of benign tumors and lesions. We report a case of PCa in which 68 Ga-PSMA-11 uptake was noted in the tracheal lumen. However, 18F-PSMA-1007 PET/CT was done on a subsequent day, which demonstrated no abnormal radiotracer uptake or morphological lesion within the tracheal lumen. This case highlights an uncommon finding of PSMA ligand uptake in a tracheal mucus plug (non-prostatic benign uptake), which may be misinterpreted as a false-positive finding.
Piyush Aggarwal,Anwin Joseph Kavanal,Harmandeep Singh,Rajender Kumar,Rajeev Ranjan,Jitupam Baishya,Anish Bhattacharya 대한핵의학회 2021 핵의학 분자영상 Vol.55 No.6
Hodgkin’s lymphoma most commonly presents as painless lymphadenopathy and systemic B symptoms like fever, nightsweats, and weight loss. But rarely, it can present with unusual paraneoplastic manifestations. In the present case, we reporta 30-year-old woman who presented with sub-acute onset pan-cerebellar symptoms. The serum neuronal antibody panel wasnegative. She underwent F-18 FDG PET/CT to evaluate the neoplastic etiology as the underlying cause, which demonstratedboth the primary etiology and the paraneoplastic changes in the brain.
Kunal Ramesh Chandekar,Sindhu Tanigassalam,Anwin Joseph Kavanal,Singh Harmandeep,Anish Bhattacharya,Ravimohan Suryanarayan Mavuduru 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.2
The rapidly evolving clinical utility of prostate-specific membrane antigen (PSMA) PET/CT as an imaging modality for prostate cancer (PCa) has brought to the forefront a multitude of non-prostatic diseases also exhibiting PSMA radioligand uptake. We report a case of a 71-year-old male with PCa who underwent PSMA PET/CT for recurrence evaluation. The scan demonstrated [68 Ga]Ga-PSMA-11 uptake in the distal ileum. Retrospective enquiry revealed that the patient was a known case of Crohn’s disease. This case highlights an uncommon finding of PSMA radioligand uptake in the distal small bowel (non-prostatic benign pathological uptake) in a patient with known Crohn’s disease, which may be misinterpreted in the evaluation of PCa.
Gaurav Prakash,Arihant Jain,Kamalkant Sahu,Amanjit Bal,Charanpreet Singh,Rajender Basher,Harmandeep Singh,Kundan Mishra,Aditya Jandial,Deepesh Lad,Alka Khadwal,Radhika Srinivasan,Ashim Das,Neelam Varm 대한혈액학회 2021 Blood Research Vol.56 No.3
Background This study evaluated the outcomes of patients with refractory/relapsed Hodgkin lymphoma (RRHL) treated with a bendamustine-based regimen in combination with ifosfamide, etoposide, and vinorelbine (VIBE). Methods Consecutive RRHL patients who were treated with the VIBE regimen were identified and studied for clinicopathologic characteristics, response to VIBE regimen, event-free survival (EFS), and feasibility of an autologous stem-cell transplant (autoSCT). Results In total, 24 patients received the VIBE regimen, and a median of 3 cycles were administered. In this cohort, 80% of the patients had received ≥2 prior lines of therapy. The overall and complete response rates with VIBE were 79% and 42%, respectively. After a median follow-up (following VIBE regimen) of 14 months (range, 3‒76), the 3-year EFS and OS were 46% and 74%, respectively. Of the eligible patients, 92% underwent successful AutoSCT. The mean CD34+ cell count in the autograft was 5.5×106 /kg (SD 2.07). Neutropenia was the commonest hematologic toxicity and it was observed in 42% of the patients. However, only 9% of the patients developed grade III/IV febrile neutropenia. Chemotherapy-induced nausea and vomiting were the second most common grade III/IV toxicities in our cohort of patients. Conclusion In this retrospective analysis, the combination regimen, VIBE, has shown good efficacy in heavily pre-treated patients with RRHL without compromising stem cell collection. These encouraging results provide a rationale for further development of this regimen.