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RISS 인기검색어
- 검색키워드
- 저자 : Simona Marafioti (검색결과 2 건)
- 무료
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Training-induced changes in clotting parameters of athletic horses
Giuseppe Piccione,Marilena Bazzano,Claudia Giannetto,Simona Marafioti,Francesco Fazio 대한수의학회 2014 JOURNAL OF VETERINARY SCIENCE Vol.15 No.1
The purpose of this study was to investigate the effects oftraining on prothrombin time, activated partial thromboplastintime, and fibrinogen (Fb) concentrations in horses to assesspotential adaptive response to training. Fifteen clinicallyhealthy horses were enrolled in the present study and equallydivided into three groups. Group A completed an intensetraining program, group B participated in a light trainingprogram, and group C included sedentary horses. After 5 weeks,group B was subjected to the same training program completedby group A and renamed group B1. Blood samples werecollected by jugular venipuncture from each animal at rest andanalyzed within 2 h after sampling. A two-way ANOVA forrepeated measures showed a significant effect of training (p <0.05) on Fb concentrations in group B1 alone during the firstweek after changing the training program. Our findingsdemonstrated that Fb is a parameter susceptible to training. Fbplasma levels increase with a more intense training program. However, Fb plasma levels decreased after the first week andreturned to basel levels, suggesting that the horses had adaptedto the new training program.
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Effects of hydrocortisone and aminophylline on the aggregation of equine platelets in vitro
Stefania Casella,Elisabetta Giudice,Claudia Giannetto,Simona Marafioti,Giuseppe Piccione 대한수의학회 2011 JOURNAL OF VETERINARY SCIENCE Vol.12 No.3
The purpose of this study was to evaluate in vitro the effects of hydrocortisone and aminophylline on adenosine diphosphate (ADP)-induced platelet aggregation in horses. Blood samples from 30 healthy Thoroughbred horses were collected by via jugular venipuncture to assess platelet aggregation. Platelet-rich and platelet-poor plasma were prepared from all samples by centrifugation and divided into three different aliquots. In the first aliquot, platelet aggregation was measured after platelet activation with 1 μM and 0.5 μM ADP (Group A). In the other two aliquots, the effect of a 10 min preincubation with hydrocortisone (Group B) or aminophylline (Group C) on ADP-induced aggregation at final ADP concentrations of 1 μM and 0.5 μM was observed. Platelet aggregation, recorded by an aggregometer, was evaluated by measuring the maximum degree of platelet aggregation and the initial velocities of platelet aggregation were obtained. Our results demonstrated the inhibitory effect of hydrocortisone and the induction effect of aminophylline on equine platelet responses in vitro.
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