http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Gulam Mohammed Husain,Syed Shoeb Ahmed,Misbahuddin Azhar,Javed Inam Siddiqui,Mohammad Abdul Waheed,Munawwar Husain Kazmi 한국한의학연구원 2017 Integrative Medicine Research Vol.6 No.1
Background: Jawarish Jalinoos (JJ) is a classical semisolid traditional Unani formulation clinically used for the treatment of weakness of vital organs, liver, and stomach. Although JJ has been widely used clinically for several decades, no scientific report is available for its safety. Methods: JJ and its sugar-free tablet version (SFJJ; formulated to target diabetic population) were assessed for safety in rats. Ninety-day repeated dose oral toxicity study was performed as per the Organisation for Economic Co-operation and Development Guideline 408. JJ was orally administered at the dose of 2000 mg/kg bw/d, whereas SFJJ was orally administered at the doses of 506 mg/kg body weight (bw)/d, 1012 mg/kg bw/d, and 2024 mg/kg bw/d for 90 days. The animals were periodically observed for clinical signs of toxicity, mortality, morbidity, body weight changes, and feed consumption. At the end of the study, hematology, clinical biochemistry, electrolytes, gross pathology, relative organ weight, and histological examination were performed. Results: Treatment with SFJJ and JJ showed no significant differences in body weight gain, feed consumption, hematology, clinical biochemistry, and serum electrolytes. No gross pathological findings and differences in relative organ weights were observed between control and drug treated rats. Histological examination revealed no toxicologically significant abnormalities related with SFJJ or JJ treatment. Conclusion: The 90-day repeated dose oral toxicity study demonstrates that the no observed adverse effect level of SFJJ and JJ is greater than 2024 mg/kg bw/d and 2000 mg/kg bw/d (p.o.) in rats, respectively. Both formulations were found to be safe up to the tested dose levels and experimental conditions, and therefore safe for clinical use as specified in the literature.
Satyajit Dey Sarker,,Mohammad Shoeb,,Sezgin Celik,Marcel Jaspars,,Lutfun Nahar,,Paul Kong-Thoo-Lin,Stephen M MacManus 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.4
Plants from the genus Centaurea (C.) (Family: Asteraceae alt. Compositae), widely distributed in Asia, Europe and North America, have traditionally been used in the treatment of various ailments. As a part of our on-going studies on the plants from the genus C. for their phytochemistry and biological activities, extracts of the seeds of Turkish endemic C. species, C. bornmuelleri and C. huber-morathii, were tested for their cytotoxicity towards the CaCo2 colon cancer cell line as well as for the toxicity towards the brine shrimps, using the MTT and the brine shrimp lethality assays, respectively. Among the extracts, the MeOH extract of these plants showed significant toxicity towards the brine shrimps (LD50 = 55.2×10-2 and 42.4×10-2 mg/ml, respectively). The MeOH extract of both C. species also inhibited the growth of CaCo2 colon cancer cells in the MTT assay (IC50 = 29.9 and 33.0 g/ml, respectively). As the most prominent activities in both assays were observed with the MeOH extracts, it can be assumed that the compound(s) responsible for these activities are polar in nature.
Sarker, Satyajit Dey,Shoeb, Mohammad,Celik, Sezgin,Jaspars, Marcel,Nahar, Lutfun,Kong-Thoo-Lin, Paul,MacManus, Stephen M Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.4
Plants from the genus Centaurea (C.) (Family: Asteraceae alt. Compositae), widely distributed in Asia, Europe and North America, have traditionally been used in the treatment of various ailments. As a part of our on-going studies on the plants from the genus C. for their phytochemistry and biological activities, extracts of the seeds of Turkish endemic C. species, C. bornmuelleri and C. huber-morathii, were tested for their cytotoxicity towards the CaCo2 colon cancer cell line as well as for the toxicity towards the brine shrimps, using the MTT and the brine shrimp lethality assays, respectively. Among the extracts, the MeOH extract of these plants showed significant toxicity towards the brine shrimps ($LD_{50}=55.2{\times}10^{-2}\;and\;42.4{\times}10^{-2}mg/ml$, respectively). The MeOH extract of both C. species also inhibited the growth of CaCo2 colon cancer cells in the MTT assay ($IC_{50}$=29.9 and 33.0 g/ml, respectively). As the most prominent activities in both assays were observed with the MeOH extracts, it can be assumed that the compound(s) responsible for these activities are polar in nature.
Antibacterial and antioxidant activities of three Turkish species of the genus Centaurea
Sarker, Satyajit Dey,Kumarasamy, Yashodharan,Shoeb, Mohammad,Celik, Sezgin,Eucel, Ersin,Middleton, Moira,Nahar, Lutfun Kyung Hee Oriental Medicine Research Center 2005 Oriental pharmacy and experimental medicine Vol.5 No.3
A number of species of the genus Centaurea (Family: Asteraceae), distributed in various parts of Asia, Europe and North America, have been used in traditional plant-based medicine and reported to possess various medicinal properties. As part of our continuing evaluation of plants from the genus Centaurea for their phytochemistry and biological activities, the dichloromethane (DCM) and methanol (MeOH) extracts of the seeds of Turkish Centaurea species, C. bornmuelleri, C. huber-morathii and C. schiskinii, were screened for antioxidant and antibacterial activities. Among the three species, C. huber-morathii displayed the most prominent antibacterial activity. Both the MeOH and DCM extracts of this plant showed activity against Citrobacter freundii, Enterococcus faecalis and Salmonella goldcoast with the MIC values within the range of $1\;{\times}\;10^{-2}\;to\;1\;{\times}\;10^{-3}\;mg/ml$. The MeOH extract of C schiskinii showed activity $(MIC\;=\;1\;{\times}\;10^{-1}\;mg/ml)$ against Citrobacter freundii and Staphylococcus aureus. While the DCM extract of C. bornmuelleri was only active against Staphylococcus aureus $(MIC\;=1\;{\times}\;10^{-2}\;mg/ml)$, the MeOH extract did not show any inhibitory activity at test concentrations. The DCM and MeOH extracts of all three species demonstrated good degree of antioxidant property in the DPPH assay with the $RC_{50}$ values ranging from $72\;{\times}\;10^{-2}\;to\;31{\times}\;10^{-3}\;mg/ml$. Among these extracts, the MeOH extract of C. hubermorathii was the most active antioxidant extract $(MlC\;=\;31\;{\times}\;10^{-3}\;mg/ml)$.
Ruby Aslam,Mohammad Mobin,Huda,Mohd Shoeb,Manilal Murmu,Priyabrata Banerjee 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.100 No.-
The synthesis of novel L-proline nitrate ionic liquid referred to as [Pro][NO3] (IL), was performed and the1H, 13C NMR, and FT-IR spectroscopic techniques were used to elucidate the chemical structure. Theinhibition properties of the [Pro][NO3] IL were evaluated for mild steel (MS) corrosion in 1 M HCl usinggravimetric measurement, electrochemical impedance spectroscopy (EIS), potentiodynamic polarization(PDP) measurement, FT-IR spectroscopy, X-ray photoelectron spectroscopy (XPS), contact anglemeasurement, scanning electron microscopy (SEM), density functional theory (DFT) and Monte Carlo(MC) simulation studies. As indicated by electrochemical and weight loss techniques the tested [Pro][NO3] IL was established as an excellent mixed type high-temperature acid corrosion inhibitor for MS; theoptimal temperature and concentration being 70 C and 300 ppm, respectively. Furthermore, the contactangle measurement and surface studies revealed water-repelling property and the protecting capability,respectively of the investigated inhibitor. The electronic property of [Pro][NO3] IL has been exploredusing density functional theory (DFT) and the sites susceptible for electron sharing were identifiedthrough Fukui indices analysis. Furthermore, molecular dynamics simulation based on the Monte Carlomethod has been employed to envisage the spontaneous adsorption of [Pro][NO3] IL on MS surface.