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Shinyoung Jun(Shinyoung Jun),Madhawa Gunathilake(Madhawa Gunathilake ),Jeonghee Lee(Jeonghee Lee),Jae Hwan Oh(Jae Hwan Oh),Hee Jin Chang(Hee Jin Chang),Dae Kyung Sohn(Dae Kyung Sohn),Aesun Shin(Aesun 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES: Previous human trials have not supported the anticarcinogenic effect of vitamin E despite biological plausibility and considerable epidemiological evidence. A possible explanation for this inconsistency is the interactive effect of the catechol-O-methyltransferase (COMT) gene and supplemental vitamin E on cancer. We examined whether a COMT gene variant modulates the effect of dietary vitamin E intake on colorectal cancer (CRC) risk. METHODS: In this case-control study of Korean adults (975 cases and 975 age- and sex-matched controls), dietary vitamin E density (mg/1,000 kcal) was measured using a semiquantitative food frequency questionnaire, COMT single nucleotide polymorphism (SNP) rs740603 (A>G) was genotyped, and CRC was verified histologically. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression models with adjustments for potential confounders. RESULTS: Higher vitamin E density was associated with a lower risk of CRC (highest vs. lowest quartiles: OR, 0.72; 95% CI, 0.55 to 0.96; p-for-trend=0.002). When stratified by COMT SNP rs740603 genotype, the inverse association between vitamin E density and CRC risk was confined to those with at least 1 A allele (≥median vs. <median: OR, 0.63; 95% CI, 0.51 to 0.78). The interaction between rs740603 and vitamin E density was significant (p-for-interaction=0.020). No direct association was observed between COMT SNP rs740603 and CRC risk (OR, 1.08; 95% CI, 0.83 to 1.41). CONCLUSIONS: Our findings support a role for a genetic polymorphism in COMT in modifying the association between dietary vitamin E intake and CRC.
Further characterization of a rice AGL12 group MADS-box gene, OsMADS26.
Lee, Shinyoung,Woo, Young-Min,Ryu, Sung-Il,Shin, Young-Duck,Kim, Woo Taek,Park, Ky Young,Lee, In-Jung,An, Gynheung American Society of Plant Physiologists 2008 Plant Physiology Vol.147 No.1
<P>Plant MADS-box genes can be divided into 11 groups. Genetic analysis has revealed that most of them function in flowering-time control, reproductive organ development, and vegetative growth. Here, we elucidated the role of OsMADS26, a member of the AGL12 group. Transcript levels of OsMADS26 were increased in an age-dependent manner in the shoots and roots. Transgenic plants of both rice (Oryza sativa) and Arabidopsis (Arabidopsis thaliana) overexpressing this gene manifested phenotypes related to stress responses, such as chlorosis, cell death, pigment accumulation, and defective root/shoot growth. In addition, apical hook development was significantly suppressed in Arabidopsis. Plants transformed with the OsMADS26-GR (glucocorticoid receptor) fusion construct displayed those stress-related phenotypes when treated with dexamethasone. Microarray analyses using this inducible system showed that biosynthesis genes for jasmonate, ethylene, and reactive oxygen species, as well as putative downstream targets involved in the stress-related process, were up-regulated in OsMADS26-overexpressing plants. These results suggest that OsMADS26 induces multiple responses that are related to various stresses.</P>
A silicon nitride microdisk resonator with a 40-nm-thin horizontal air slot
Lee, Shinyoung,Eom, Seok Chan,Chang, Jee Soo,Huh, Chul,Sung, Gun Yong,Shin, Jung H. The Optical Society 2010 Optics express Vol.18 No.11
<P>We design and fabricate pedestal-type, 15 microm diameter silicon nitride microdisk resonators on Si chip with horizontal air-slot using selective wet etching between Si, SiO2, and SiNx. As the slot structure is determined by deposition process, air slots that are as thin as 40 nm and as deep as 5 microm with ultra-smooth slot surfaces can easily be fabricated with photolithography only. Fundamental TM-like slot mode in which the E-field is greatly enhanced within slot was observed with an intrinsic Q factor of approximately 34,000 (lambdares=1523.7 nm) and energy overlap in slot region of 21.6%.</P>
Lee, Myeongjae,Kim, Min Je,Ro, Suhee,Choi, Shinyoung,Jin, Seon-Mi,Nguyen, Hieu Dinh,Yang, Jeehye,Lee, Kyung-Koo,Lim, Dong Un,Lee, Eunji,Kang, Moon Sung,Choi, Jong-Ho,Cho, Jeong Ho,Kim, BongSoo American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.34
<P>High carrier mobilities have recently been achieved in polymer field effect transistors (FETs). However, many of these polymer FET devices require the use of chlorinated solvents such as chloroform (CF), chlorobenzene (CB), and odichlorobenzene (DCB) during fabrication. The use of these solvents is highly restricted in industry because of health and environmental issues. Here, we report the synthesis of a low band gap (1.43 eV, 870 nm) semiconducting polymer (PDPP2DT-F2T2) having a planar geometry, which can be readily processable with nonchlorinated solvents such as toluene (TOL), o-xylene (XY), and 1,2,4-trimethylbenzene (TMB). We performed structural characterization of PDPP2DT-F2T2 films prepared from different solvents, and the electrical properties of the films were measured in the context of FETs. The devices exhibited an ambipolar behavior with hole dominant transport. Hole mobilities increased with increasing boiling point (bp) of the nonchloririated solvents: 0.03, 0.05, and 0.10 cm(2) V-1 s' for devices processed using TOL, XY, and TMB, respectively. Thermal annealing further improved the FET performance. TMB-based polymer FETs annealed at 200 degrees C yielded a maximum hole mobility of 1.28 cm(2) s(-1), which is far higher than the 0.43 cm(2) V-1 s(-1) obtained from the CF-based device. This enhancement was attributed to increased interchain interactions as well as improved long-range interconnection between fibrous domains. Moreover, all of the nonchlorinated solutions generated purely edge-on orientations of the polymer chains, which is highly beneficial for carrier transport in FET devices. Furthermore, we fabricated an array of flexible TMBprocessed PDPP2DT-F2T2 FETs on the plastic PEN substrates. These devices demonstrated excellent carrier mobilities and negligible degradation after 300 bending cycles. Overall, we demonstrated that the organized assembly of polymer chains can be achieved by slow drying using high bp nonchlorinated solvents and a post thermal treatment. Furthermore, we showed that polymer FETs processed using high bp nonhalogenated solvents may outperform those processed using halogenated solvents.</P>
Label-free optical biosensing using a horizontal air-slot SiN_x microdisk resonator
Lee, Shinyoung,Eom, Seok Chan,Chang, Jee Soo,Huh, Chul,Sung, Gun Yong,Shin, Jung H. The Optical Society 2010 Optics express Vol.18 No.20
<P>We demonstrate label-free optical biosensing using a horizontal air-slotted silicon-rich silicon nitride (SiNx) microdisk resonator. Due to the strong confinement of light in the air-slot, a large resonance shift of 6.2 nm is observed upon reaction of the biotin-functionalized disk with a streptavidin solution with concentration of 2.5 관g/ml. Assuming a linear relationship between resonance shift and streptavidin concentration, we estimate the sensitivity to be 2.5 ± 0.2 nm/(관g/ml). Comparing this value with surface sensitivity of 5.7 nm/nm calculated using FDTD simulations, a detection limit of 30 ± 2 ng/ml, is extrapolated.</P>
Lee, Shinyoung,Choi, Sang Chul,An, Gynheung Blackwell Publishing Ltd 2008 The Plant journal Vol.54 No.1
<P>Summary</P><P>Most short vegetative phase (SVP)-group MADS-box genes control meristem identity and flowering time. Among the three SVP-group genes in rice, OsMADS47 has been reported as a negative regulator of brassinosteroid (BR) responses. Here, we investigated the functional roles of two close homologs, OsMADS22 and OsMADS55, by generating single, double and triple RNAi lines and overexpression lines. Analyses of the plants showed that their roles in regulating meristem identity are well conserved; however, the involvement of these genes in determining flowering time has diversified. Most importantly, OsMADS55 works as a major negative regulator of BR responses, and OsMADS22 functions to support OsMADS55. Whereas single <I>OsMADS55</I> RNAi plants display weak BR responses in the lamina joint (LJ), <I>OsMADS22</I>-<I>OsMADS55</I> double and <I>OsMADS22</I>-<I>OsMADS47</I>-<I>OsMADS55</I> triple RNAi plants manifest dramatic BR responses with regard to LJ inclination, coleoptile elongation and senescence. Stem elongation is also notably reduced in the double and triple RNAi plants, probably because of BR oversensitivity. Expression analyses indicate the diversified roles in age-dependent BR responses. Altogether, our study demonstrates that all three rice SVP-group genes work as negative regulators of BR responses, but that their spatial and temporal roles are diversified.</P>