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Shinya Yamada,Li-Wei Lo,Yenn-Jiang Lin,Shih-Lin Chang,Fa-Po Chung,Yu-Feng Hu,Ta-Chuan Tuan,Tze-Fan Chao,Jo-Nan Liao,Chin-Yu Lin,Shih-Ann Chen 대한심장학회 2019 Korean Circulation Journal Vol.49 No.1
Background and Objectives: The differences between electromagnetic-based mapping (EM) and impedance-based mapping (IM) in 3D anatomical reconstruction have not been fully clarified. We aimed to investigate the anatomical accuracy between EM (MediGuide™) and IM (EnSite Velocity™) systems. Methods: We investigated 15 consecutive patients (10 males, mean age 58±9 years) who underwent pulmonary veins (PVs) isolation for paroxysmal atrial fibrillation (PAF). Contrast-enhanced computed tomography (CT) image of the left atrium (LA) was acquired before ablation and the 3D geometry of the LA was constructed using EM during ablation procedure. We measured the 4 PV angles between the main trunk of each PV and the posterior LA after field scaling. Additionally, the posterior LA surface area was measured. The variables were compared to those of CT-based geometry. A control group of 40 patients who underwent conventional PVs isolation using IM were also evaluated. Results: The actual and relative changes of EM and CT-based geometry in all PV angles and posterior LA were significantly smaller compared to those of IM and CT-based geometry. Intraclass correlation coefficient (ICC) between EM and CT-based geometry were 0.871 (right superior pulmonary vein [RSPV]), 0.887 (right inferior pulmonary vein [RIPV]), 0.853 (left superior pulmonary vein [LSPV]), 0.911 (left inferior pulmonary vein [LIPV]), and 0.833 (posterior LA). On the other hand, ICC between IM and CT-based geometry were 0.548 (RSPV), 0.639 (RIPV), 0.691 (LSPV), 0.706 (LIPV), and 0.568 (posterior LA). Conclusions: Image integration with EM enables high accurate visualization of cardiac anatomy compared to IM in PAF ablation.
High-frequency Induction Heating for Tiny Foreign Metals
Shinya Kurachi,Naoki Yamamoto,Hiroaki Yamada,Toshihiko Tanaka,Eiji Hiraki,Yukiharu Yamada,Tatsuya Nagao,Yasuhiro Miyake,Yujiro Noda 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
The anxiety of tiny metal contamination into resin materials in the manufacturing process has become one of the serious issues. Because it may often cause of overheat in lithium-ion batteries, flat panel displays, and so on. Therefore, a study on detecting method of the tiny metals is a significant issue. The authors have been investigating the high-frequency induction heating (IH) based approach for tiny metals detection. In this paper, effective magnetic circuit design and IH conditions are discussed and demonstrated from theoretical and experimental point of view.
Kochi, Yuta,Yamada, Ryo,Suzuki, Akari,Harley, John B,Shirasawa, Senji,Sawada, Tetsuji,Bae, Sang-Cheol,Tokuhiro, Shinya,Chang, Xiaotian,Sekine, Akihiro,Takahashi, Atsushi,Tsunoda, Tatsuhiko,Ohnishi, Yo Nature Publishing Group 2005 Nature genetics Vol.37 No.5
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-κB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.