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Central nervous system depressant activity of Diospyros peregrina bark
Shilpi, Jamil Ahmad,Uddin, Shaikh Jamal,Rouf, Razina,Billah, Md. Morsaline Kyung Hee Oriental Medicine Research Center 2004 Oriental pharmacy and experimental medicine Vol.4 No.4
The methanol extract of Diospyros peregrina bark was studied for its effect on the central nervous system (CNS) using the pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract, at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to the control. In open field test, the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed from the second observation period (30 min) and persisted up to fifth observation period (120 min) for 250 mg dose group and up to sixth observation period (180 min) for 500 mg dose group. These results support the finding that D. peregrina bark extract at the above doses has CNS depressing effects and indicate that D. peregrina bark may contain biologically active constituent(s) having CNS depressant activity.
Implementation of Biometric Techniques in Social Networking Sites
Shilpi Sharma,J. S. Sodhi 보안공학연구지원센터 2014 International Journal of Security and Its Applicat Vol.8 No.6
With the advancement of technologyprivacy threats arise while establishing communication in social networking sites. For the developers of authentication systems user’s privacy and authentication have evolved as a major problem and area of concern. This research is based on an attempt to discuss the implementation of different biometric verification techniques in order to perform the authentication of users in social networking sites. It decreases the chances of illegal impersonation thus enhancing the privacy of an individual’s personal data. The prime objective of this paper is to provide a new revolution in social networking sites by suggesting remedial measures for the security threats faced in the sites such as Facebook, MySpace, Twitter, Hi5, LinkedIn, Orkut, Tumbler, Flikeretc so that the goal of communication can be achieved without any security threat in mind. Application of securedbiometricsenables confirmation of personal detailsfor establishing the identity of an individual.
Shilpi, Jamil Ahmad,Rouf, Razina,Ferdous, MM,Uddin, Shaikh Jamal Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.1
The ethanolic extract of Fleurya interrupta Gaud, (Urticaceae) was tested for its possible neuropharmacological effects on experimental animals, For the primary neuropharmacological screening of this plant, the ethanolic extract of its aerial parts was subjected to preliminary evaluation for acute toxicity, antinociceptive activity and central nervous system (CNS) activities. At the doses of 125 and 250 mg/kg, the extract significantly (P < 0.01 and P < 0. 001) and dose-dependently increased the frequency of acetic acid induced writhing in mice. In the pentobarbitone induced sleeping time test, the extract at the above dose levels, significantly and dose-dependently decreased the pentobarbitone induced sleeping time (P < 0.001) and increased the time for onset of sleep (P < 0.001) in mice. In the open field and hole cross tests, test animals showed an increase in their movement in the both tests from the 2nd observation period (30 min) and persisted throughout the entire experimental period (240 min). These results of the extract may attribute a stimulating action on the CNS. On the basis of these findings, it can be assumed that the extract exerts its stimulating effect on the CNS in mice by interfering with the cortical function or increasing the effect of some CNS stimulating neurotransmitters.
Thermal instability of a nanofluid layer under local thermal non-equilibrium
Agarwal Shilpi,Bhadauria Beer Singh 나노기술연구협의회 2015 Nano Convergence Vol.2 No.6
In this paper, we study the effect of local thermal non-equilibrium on the linear thermal instability in a horizontal layer of a Newtonian nanofluid. The nanofluid layer incorporates the effect of Brownian motion along with thermophoresis. A two-temperature model has been used for the effect of local thermal non-equilibrium among the particle and fluid phases. The linear stability is based on normal mode technique and for nonlinear analysis, a minimal representation of the truncated Fourier series analysis involving only two terms has been used. We observe that for linear instability, the value of Rayleigh number can be increased by a substantial amount on considering a bottom heavy suspension of nano particles. The effect of various parameters on Rayleigh number has been presented graphically. A weak nonlinear theory based on the truncated representation of Fourier series method has been used to find the concentration and the thermal Nusselt numbers. The behavior of the concentration and thermal Nusselt numbers is also investigated by solving the finite amplitude equations using a numerical method.
Aggarwal, Shilpi,Karimi, I. A.,Lee, Dong Yup Royal Society of Chemistry 2011 Molecular bioSystems Vol.7 No.11
<P>The remarkable catabolic diversity of <I>Rhodococcus erythropolis</I> makes it an interesting organism for bioremediation and fuel desulfurization. However, a model that can describe and explain the combined influence of various intracellular metabolic activities on its desulfurizing capabilities is missing from the literature. Such a model can greatly aid the development of <I>R. erythropolis</I> as an effective desulfurizing biocatalyst. This work reports the reconstruction of the first genome-scale metabolic model for <I>R. erythropolis</I> using the available genomic, experimental, and biochemical information. We have validated our <I>in silico</I> model by successfully predicting cell growth results and explaining several experimental observations in the literature on biodesulfurization using dibenzothiophene. We report several <I>in silico</I> experiments and flux balance analyses to propose minimal media, determine gene and reaction essentiality, and compare effectiveness of carbon, nitrogen, and sulfur sources. We demonstrate the usefulness of our model by studying a few <I>in silico</I> mutants of <I>R</I>. <I>erythropolis</I> for improved biodesulfurization, and comparing the desulfurization abilities of <I>R. erythropolis</I> with an <I>in silico</I> mutant of <I>E. coli</I>.</P> <P>Graphic Abstract</P><P>This work reports the reconstruction of the first genome-scale metabolic model for <I>R. erythropolis</I> using the available genomic, experimental, and biochemical information. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1mb05201b'> </P>
agarwal,Shilpi Jain,김용섭 경남대학교 수학교육과 2018 Nonlinear Functional Analysis and Applications Vol.23 No.4
Authors established some (presumably) new fractional integral and Beta trans- form formulas for the generalized extended Appell’s and Lauricella’s hypergeometric func- tions which have recently been introduced by Kim.
Kirtisudha Mishra,Shilpy Singla,Suvasini Sharma,Renu Saxena,Vineeta Vijay Batra 대한소아청소년과학회 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.2
Griscelli syndrome type 2 (GS2) is a rare autosomal recessive disease caused by mutations in the RAB27Agene. It is characterized by cutaneous hypopigmentation, immunodeficiency, and hemophagocyticlymphohistiocytosis. We describe 2 brothers who had GS2 with clinically diverse manifestations. The elderbrother presented with a purely neurological picture, whereas the younger one presented with fever,pancytopenia, hepatosplenomegaly, and erythema nodosum. Considering that cutaneous hypopigmentationwas a common feature between the brothers, genetic analysis for Griscelli syndrome wasperformed. As the elder sibling had died, mutation analysis was only performed on the younger sibling,which revealed a novel homozygous mutation in the RAB27A gene on chromosome 15 showing asingle-base substitution (c.136T>A p.F46I). Both parents were heterozygous for the same mutation. This confirmed the diagnosis of GS2 in the accelerated phase in both siblings. The atypical features ofGS2 in these cases are a novel mutation, isolated neurological involvement in one sibling, associationwith erythema nodosum, and 2 distinct clinical presentations in siblings with the same genetic mutation.