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Nkd2, a negative regulator of Wnt pathway, delays mitotic exit in Hela cell
Yu-Jie Shi,Keke Huo 한국유전학회 2013 Genes & Genomics Vol.35 No.5
Frequent amplification and abundant expression of Nkd2 has been identified in malignant peripheral nerve sheath tumors (MPNSTs), dominant for genomic instability, who is involved in both Wnt pathway and EGFR signaling pathway. As a negative regulator of Wnt pathway, Nkd2 suppresses Wnt signaling by binding to Dvl1 and causing its ubiquitination followed by 26S proteasome degradation. On the other hand, it interacts with TGF-a for its transportation to basolateral plasma membrane in polarized epithelial cells. It is of interest to determine if Nkd2 over-expression contributes to tumorigenesis and genomic instablity. In this paper, we found that cells expressing NKD2 delayed mitotic exit stage after double thymidine block synchronization, but aneuploidy was not detected in these cells. This was further confirmed by Western blotting. In nocodazole-synchronised cells, Cyclin B1 degradation was delayed with Nkd2 overexpression compared to control group. Given many previous publications showed that Wnt pathway components areinvolved in mitotic progression. Further investigation on Nkd2’s function in mitosis might give more clues on MPNSTs pathological progression.
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Active Speed Control of Belt Conveyor with Variable Speed Interval Based on Fuzzy Algorithm
Zhou Qixun,Gong Hao,Sun Wenhao,Yan Qi,Shi Keke,Du Guanghui 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.3
Aiming at the problems of too fast adjustment frequency, unstable material flling rate and fuctuation of material fow at the boundary of speed interval caused by unreasonable setting of speed interval in traditional active speed control strategy based on hierarchical speed regulation. An active speed control strategy based on fuzzy algorithm is proposed for belt conveyor. The material flling rate of the belt is taken as input, and the double-layer fuzzy boundary is set according to the expected value of the material flling rate to adjust the speed of the belt conveyor. The adjustment time of diferent speed intervals is given according to the estimation-calculation-optimization method. The simulation results of the double belt conveyor system show that compared with the active speed control strategy based on hierarchical speed regulation, the active speed control strategy can not only stabilize the material flling rate of the downstream belt conveyor near the expected value and improve the stability of transportation, but also reduce the energy by about 20.69% per hour on average. The subsequent experimental results also verify the efectiveness of the proposed active speed control strategy, which can achieve more sustainable operation of the belt conveyor.
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