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RISS 인기검색어
- 검색키워드
- 저자 : Shaozhong He (검색결과 3 건)
- 무료
- 기관 내 무료
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Wind tunnel test research on aerodynamic means of the ZG Bridge
He, Xiangdong,Xi, Shaozhong Techno-Press 1999 Wind and Structures, An International Journal (WAS Vol.2 No.2
The ZG Bridge(preliminary design), with unfavorable aerodynamic stability characteristics, is a truss-stiffened suspension bridge, its critical wind speed of flutter instability is much lower than that of code requirement, In the present paper, based on both aerostatic and aeroelastic section model wind tunnel test, not only effects of some aerodynamic means on aerodynamic stability of its main girder are investigated, but also such effective aerodynamic means of it as flap and plate-like center stabilizer are concluded.
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Sox12 Is a Cancer Stem-Like Cell Marker in Hepatocellular Carcinoma
Zou, Song,Wang, Chen,Liu, Jiansheng,Wang, Qun,Zhang, Dongdong,Zhu, Shengnan,Xu, Shengyuan,Kang, Mafei,He, Shaozhong Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.11
Recent studies on molecular carcinogenesis suggest that the chemo-resistance of some cancers is largely due to presence of cancer stem cells (CSCs), which affect the chemotherapy outcome for hepatocellular carcinoma (HCC). However, currently no consensus on a CSC phenotype in HCC has been obtained. Here, we examined Sox12 as a novel CSC marker in HCC. Sox12+ versus Sox12- cells were purified from HCC cell lines. The Sox12+ cells were compared with Sox12- HCC cells for tumor sphere formation, chemo-resistance, tumor formation after serial adoptive transplantations in nude mice, and the frequency of developing distal metastasis. We found that compared to Sox12- HCC cells, Sox12+ HCC cells generated significantly more tumor spheres in culture, were more chemo-resistant to cisplatin, were detected in circulation more frequently, and formed distal tumor more frequently. Moreover, Sox12 appeared to functionally contribute to the stemness of HCC cells. Thus, we conclude that Sox12 may be a novel marker for enriching CSCs in HCC.
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Sox12 Is a Cancer Stem-Like Cell Marker in Hepatocellular Carcinoma
Song Zou,Chen Wang,Jiansheng Liu,Qun Wang,Dongdong Zhang,Shengnan Zhu,Shengyuan Xu,Mafei Kang,Shaozhong He 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.11
Recent studies on molecular carcinogenesis suggest that the chemo-resistance of some cancers is largely due to presence of cancer stem cells (CSCs), which affect the chemotherapy outcome for hepatocellular carcinoma (HCC). However, currently no consensus on a CSC phenotype in HCC has been obtained. Here, we examined Sox12 as a novel CSC marker in HCC. Sox12+ versus Sox12- cells were purified from HCC cell lines. The Sox12+ cells were compared with Sox12- HCC cells for tumor sphere formation, chemo-resistance, tumor formation after serial adoptive transplantations in nude mice, and the frequency of developing distal metastasis. We found that compared to Sox12- HCC cells, Sox12+ HCC cells generated significantly more tumor spheres in culture, were more chemo-resistant to cisplatin, were detected in circulation more frequently, and formed distal tumor more frequently. Moreover, Sox12 ap-peared to functionally contribute to the stemness of HCC cells. Thus, we conclude that Sox12 may be a novel marker for enriching CSCs in HCC.
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