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      • Phase II Study on Voriconazole for Treatment of Chinese Patients with Malignant Hematological Disorders and Invasive Aspergillosis

        Zhang, Xue-Zhong,Huang, Xin-En,Xu, Yan-Li,Zhang, Xiu-Qun,Su, Ai-ling,Shen, Zheng-Shan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

        Objective: To investigate the efficacy and safety of voriconazole in treating Chinese patients with hematological malignancies and invasive aspergillosis. Methods: From March 2007 to April 2012, patients with diagnoses confirmed by CT, GM test and/or PCR assays, were recruited into this study. Aspergillosis of all patients were treated with voriconazole 6 mg/kg intravenous infusion (iv) every 12 h for 1 day, followed by 4 mg/kg IV every 12 h for 10-15 days; Then, switch to oral administration that was 200mg every 12h for 4-12 weeks. Efficacy and safety were evaluated according to Practice Guideline of Infectious Diseases Society of America. Results: The overall response rate of 38 patients after voriconazole treatment was 81.6%. The median time to pyretolysis was 4.5 days. Treatment related side effects were mild and found in only 15.8% of cases. No treatment related deaths occurred. Conclusions: Voriconazole can considered to be a safe and effective front-line therapy to treat patients with hematological malignancies and invasive aspergillosis. Alternatively it could be used as a remedial treatment when other antifungal therapies are ineffective.

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        과거 30년간 기온상승으로 인한 한반도 생물계절성 변화 연구

        Xu, JinFeng,ZHUYONGYAN,Meng, Su Xin,Huang, Xiao,PIAODONGFAN,Cui, Gui Shan 한국기후변화학회 2019 한국기후변화학회지 Vol.10 No.4

        Vegetation phenology changes play a key role in the carbon and nutrient cycle of terrestrial ecosystems. Phenology findings based on satellite observations have mainly concentrated on the northern hemisphere or Eurasia and the American continent, with few small‐scale studies on special climate environments. In this study, we used five methods to extract the Start of Growing Season (SOS), End of Growing Season (EOS) and Length of Growing Season (GSL) dates from NDVI records for the Korean Peninsula from 1982 to 2015, and determined the time correlation between SOS, EOS and maximum temperature (Tmax) and minimum temperature (Tmin). In general, phenological changes in the Korean peninsula vary from the findings drawn from the northern hemisphere scale. The SOS advance rate on the Korean peninsula is about 0.01 days / year, the fall phenology delay rate is about 0.24 days per year (p <0.05), and the growing season extension rate is about 0.23 days/year. By investigating the phenology of North Korea and South Korea separately using the 38‐line boundary, we found no statistically significant changes in SOS and GSL in North Korea. At the same time, SOS, EOS, and GSL in South Korea have changed significantly over this period. The prolongation of the growing season on the Korean Peninsula is mainly due to the delayed phenology of autumn. Vegetation phenology in South Korea’s marine climate is more strongly influenced by Tmin.

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        Imaging Spectrum after Pancreas Transplantation with Enteric Drainage

        Jian-Ling Chen,Rheun-Chuan Lee,Yi-Ming Shyr,Sing-E Wang,Hsiuo-Shan Tseng,Hsin-Kai Wang,Shan-Su Huang,Cheng-Yen Chang 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.1

        Since the introduction of pancreas transplantation more than 40 years ago, surgical techniques and immunosuppressive regiments have improved and both have contributed to increase the number and success rate of this procedure. However, graft survival corresponds to early diagnosis of organ-related complications. Thus, knowledge of the transplantation procedure and postoperative image anatomy are basic requirements for radiologists. In this article, we demonstrate the imaging spectrum of pancreas transplantation with enteric exocrine drainage.

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