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      • SCOPUSKCI등재

        Association between assisted reproductive technology and autism spectrum disorders in Iran: a case-control study

        Jenabi, Ensiyeh,Seyedi, Mahdieh,Hamzehei, Ronak,Bashirian, Saeid,Rezaei, Mohammad,Razjouyan, Katayoon,Khazaei, Salman The Korean Pediatric Society 2020 Clinical and Experimental Pediatrics (CEP) Vol.63 No.9

        Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by impairments in social interaction and verbal and nonverbal communication. Purpose: Determine the association between use of assisted reproduction technology (ART) and the risk of ASD among children. Methods: This case-control study included 300 participants (100 cases, 200 controls). The control group included women with a child aged 2-10 years without ASD, while the cases were women with a child aged 2-10 years with ASD. We used a researcher-made questionnaire. Data were analyzed using Stata ver. 14 at the 0.05 significance level. Results: In the univariate analysis, there was significant association between child sex, delivery mode, history of preterm delivery, history of using ART, and maternal age at child's birth and the risk of ASD. After the adjustment for other variables, this association was significant for male sex (2.66; 95% confidence interval [CI], 1.11-4.31; P=0.001) and history of using ART (4.03; 95% CI, 1.76-9.21; P=0.001). Therefore, after the adjustment for confounder variables, there was no significant association between ART and the risk of ASD among children (4.98; 95% CI, 0.91-27.30; P=0.065). Conclusion: After the adjustment for other variables, risk factors for ASD were male sex and history preterm delivery. Thus, there was no significant association between ART and the risk of ASD among children.

      • KCI등재

        Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?

        Jenabi, Ensiyeh,Seyedi, Mahdieh,Bashirian, Saeid,Fereidooni, Bita The Korean Pediatric Society 2021 Clinical and Experimental Pediatrics (CEP) Vol.64 No.9

        Background: There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. Purpose: This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. Methods: All observational studies (case-control and cohort) were reviewed until September 2020 after searches of the PubMed, Scopus, and Web of Science databases, the gray literature, and conference proceedings. The pooled odds ratios (ORs), relative ratios (RRs), and 95% confidence intervals (CI (swere calculated as random effect estimates of association among studies. Results: All observational studies were reviewed, including 4 cohort studies including 2,885,743 participants and 3 case-control studies including 51,135 participants (10,961 with ADHD and 40,174 in control groups) with a sample size of 2,936,878 participants. The pooled estimates of OR and RR did not indicate a significant association between labor induction and ADHD among children (OR, 1.13; 95% CI, 0.90-1.35) and (RR, 1.10; 95% CI, 0.96-1.24). Conclusions: The findings showed that labor induction is not associated with an increased risk of ADHD among children. However, more studies are needed to investigate the relationship between labor induction and ADHD.

      • KCI등재

        Association between small for gestational age and risk of autism spectrum disorders: a meta-analysis

        Jenabi, Ensiyeh,Bashirian, Saeid,Asali, Zahra,Seyedi, Mahdieh The Korean Pediatric Society 2021 Clinical and Experimental Pediatrics (CEP) Vol.64 No.10

        Background: The relationship between small for gestational age (SGA) and autism spectrum disorders (ASDs) remains unknown. Purpose: This meta-analysis aimed to investigate the relationship between SGA and the risk of ASD. Methods: We searched PubMed, Web of Science, and Scopus databases from inception to November 2020. The heterogeneity across studies was explored using the I<sup>2</sup> statistic. The possibility of publication bias was assessed using Begg test. The results were reported using the odds ratio (OR) and 95% confidence interval (CI) using a random-effects model. Results: The literature search yielded 824 articles with 8,752,138 participants. We assessed the association between SGA and the risk of ASD in cohort and case-control studies. Based on the random-effects model, compared with SGA, the estimated OR of the risk of ASD was 1.17 (95% CI, 1.09-1.24). Therefore, there was a significant association between SGA and the risk of ASD. Conclusion: Based on OR reports in epidemiological studies, we showed that SGA is a risk factor for and can increase the risk of ASD. The association between SGA and ASD risk has further relevance to the current public health emphasis on appropriate prepregnancy weight and pregnancy weight gain.

      • KCI등재

        Association between previous abortion history and risk of autism spectrum disorders among offspring: a meta-analysis

        Jenabi Ensiyeh,Ayubi Erfan,Bashirian Saeid,Seyedi Mahdieh,Rezaei Mohammad 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.2

        Background: Previous studies have been showed an association between previous abortion history and risk of Autism spectrum disorders (ASD). However, there is still controversy about true effect estimate of the association.Purpose: This meta-analysis aimed to evaluate the association between previous abortion history and the risk of ASD.Methods: A systematic search was performed using PubMed, Scopus, and Web of Sciences databases to identify potential studies published until December 2021. The presence of statistical heterogeneity was determined using the <i>I<sup>2</sup></i> value. In the case of substantial heterogeneity, the random-effects model meta-analysis was used to estimate the pooled relative risks. The publication bias was assessed using the Egger and Begg tests.Results: Thirteen studies with a total of 331,779 children remained in the present meta-analysis. The estimated odds ratio of the risk of ASD associated with previous abortion history was 1.64 (95% confidence interval [CI], 1.28–2.0; <i>I<sup>2</sup></i>=61.7%) in adjusted studies and 1.10 (95% CI, 1.01–1.20; <i>I<sup>2</sup></i>=0.0%) in crude studies, based on the random effect model. There was moderate heterogeneity in adjusted studies. The p values for Egger and Begg regression among children with ASD were 0.393 and 0.056, respectively.Conclusion: This meta-analysis suggests that children born from mothers with a history of previous abortion have an increased risk of development of ASD compared to children of mothers without a history of previous abortion.

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