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Prostaglandin F receptor expression in intrauterine tissues of pregnant rats
Elvan Anadol,Halit Kanca,Atiye Seda Yar,Fatma Helvacioğlu,Sevda Menevşe,Engin Ҫalgüner,Deniz Erdoğan 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.1
In this investigation, we studied the expression andlocalization of rat prostaglandin F (FP) receptor in uterinetissues of rats on gestational Days 10, 15, 18, 20, 21, 21.5 andpostpartal Days 1 and 3 using Western blotting analysis,real-time PCR, and immunohistochemistry. A high level ofimmunoreactivity was observed on gestational Days 20, 21,and 21.5 with the most significant signals found on Day 20. FP receptor protein was expressed starting on gestationalDay 15, and a fluctuating unsteady increase was observeduntil delivery. Uterine FP receptor mRNA levels were lowbetween Days 10 and 18 of gestation (p < 0.05). Thetranscript level increased significantly on Day 20 andpeaked on Day 21.5 just before labor (p < 0.05). There wasa positive correlation between FP receptor mRNAexpression and serum estradiol levels (rs = 0.78; p < 0.01)along with serum estradiol/progesterone ratios (rs = 0.79; p < 0.01). In summary, we observed an increase FP receptorexpression in rat uterus with advancing gestation, a markedelevation of expression at term, and a concominant decreaseduring the postpartum period. These findings indicate a rolefor uterine FP receptors in the mediation of uterinecontractility at term.
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Çağrı Yayla,Kaan Okyay,Asife Şahinarslan,Akın Yılmaz,Atiye Seda Yar Sağlam,Azmi Eyiol,Hasan Ata Bolayır,Burak Sezenöz,Sevda Menevşe,Atiye Çengel 대한심장학회 2016 Korean Circulation Journal Vol.46 No.5
Background and Objectives: Genetic predisposition is an important risk factor for coronary artery disease (CAD). In this study, we aimed to evaluate the impact of rs10757274 and rs2383206 polymorphisms in chromosome 9p21 on presence and severity of CAD in a Turkish population. Subjects and Methods: A total of 646 patients who underwent coronary angiography were included in this study. Coronary vessel score and Gensini score were calculated to assess the angiographic severity of CAD. Alleles of AA, AG, and GG were determined for rs10757274 (polymorphism-1) and rs2383206 (polymorphism-2) polymorphisms located in chromosome 9p21 from the blood samples. Results: There was a significant difference between the alleles in polymorphism-1 in the presence of coronary artery disease (38.9% in AA, 48.0% in GG and 56.4% in AG, p=0.017). However, there was no difference between the alleles in polymorphism-2. According to vessel scores, there was a significant difference between the alleles in polymorphism-1 (AA 0.71±1.04, GG 0.88±1.07, AG 1.06±1.12, p=0.018). In polymorphism-2, vessel scores did not show a difference between the alleles. In polymorphism-1, there was a significant difference in Gensini score (p=0.041). Gensini scores did not differ between the alleles in polymorphism-2 (p>0.05 for all). In multivariate analyses, none of the alleles was an independent factor for presence of CAD. Conclusion: The presence of rs10757274 polymorphism including AG allele in chromosome 9p21 was related to CAD. However, this relationship was not independent of other cardiovascular risk factors.
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