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Choi, Yi-Rac,Chae, Su Young,Ahn, Cheol-Hee,Lee, Minhyung,Oh, Seungjoon,Byun, Youngro,Rhee, Byoung Doo,Ko, Kyung Soo Informa Healthcare 2007 Journal of drug targeting Vol.15 No.6
<P> Block copolymers consisting of poly(ethylene glycol) (PEG) and poly(amino acid)-based random copolymers were successfully synthesized by the ring opening polymerization of the N-carboxy anhydrides (NCA) of l-lysine and l-phenylalanine. The synthesized copolymers had a molecular weight of around 30,000 and contained l-lysine and l-phenylalanine residues with molar ratios of 10/0, 9/1, 8/2, 7/3 and 6/4. The complex formation of the copolymer and pCMV-luc plasmid DNA was confirmed by the gel retardation assay and zeta potential measurement. Complete neutralization was achieved at an N/P ratio of more than 1.0 and the size of the complex was determined to be around 150 nm by dynamic light scattering. The cytotoxicity and transfection efficiency were tested on the HEK 293T cell line. The synthesized copolymers displayed negligible cytotoxicity, resulting in a cell viability of more than 95%, while those of the poly(l-lysine) (PLL) and poly(ethylenimine) (PEI) homopolymer were around 65 and 55%, respectively, under comparable conditions. The introduction of the hydrophilic PEG is believed to reduce the toxicity of the copolymer, due to its enhanced biocompatibility, and to impart improved stability to the complex under physiological conditions. The transfection efficiency at the optimized charge ratio of 7 was dramatically improved as the molar content of the l-phenylalanine residues in the copolymers increased and reached a maximum value at an l-phenylalanine content of 30 mol%. The transfection efficiency of the PEGK7/plasmid DNA complex was around 80 times higher than that of PLL, despite the presence of neutral PEG as a block segment.</P>
Exposure to tetrabromobisphenol A induces cellular dysfunction in osteoblastic MC3T3-E1 cells
Choi, Eun Mi,Suh, Kwang Sik,Rhee, Sang Youl,Oh, Seungjoon,Kim, Sung Woon,Pak, Youngmi Kim,Choe, Wonchae,Ha, Joohun,Chon, Suk Taylor Francis 2017 Journal of environmental science and health. Part Vol.52 No.6
최창희(Changhui Choi),이승준(Seungjoon Lee) 한국데이터정보과학회 2022 한국데이터정보과학회지 Vol.33 No.3
본 연구는 지연회귀를 이용하여 코로나19가 발생하지 않았을 경우를 가정한 2020년 사망자 수를 추정하고 이를 2020년의 실제 사망자 수와 비교하여 코로나19가 사망자 수에 미친 영향을 추정하였다. 실험 결과 코호트별 추정 및 사인별 추정에서 각각 2,427명과 2,634명의 초과사망 (코로나19가 없는 경우에 비하여 증가한 사망자 수)이 발생하였다. 사인 별 추정 결과에서 상해·중독·화상(-2,212)과 호흡기질환 (-3,599)의 경우 음의 초과사망자 수 (코로나19가 없는 경우보다 감소)가 관찰되었다. 코호트 별 추정 결과에서는 50대 이하 남성 초과사망자 수가 -1,969명인데 비해, 60대 이상 여성 초과사망자 수가 4,116명 (99% 예측 구간 초과) 60대 이상 여성의 사망이 코로나19가 일어나지 않은 경우를 가정한 사망자 수보다 크게 증가한 것으로 나타났다. This research estimates the impact of COVID-19 on the deaths of year 2020 by comparing the estimated number of deaths that are produced without considering the impact of COVID-19 using a lagged-regression method and the actual number of deaths. According to the test results, 2,427 and 2,634 excess deaths (the number of deaths that exceeds the anticipated number of deaths without considering the impact of COVID-19) were estimated from the cohorts data sets and cause-of-death data sets, respectively, which exceed statistically significant levels. In cause-of-death data analysis, the excess deaths of injuries, poisoning and fire burns were -2,427 and the excess deaths of respiratory disease were -2,624. In the analysis of cohort data sets, the excess deaths of male under 60 were -1,969 whereas the excess deaths of female over 60 were +4,116, which is a quite significant number.