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Choi, Junbae,Myung, Woojae,Chung, Jae Won,Kang, Hyo Shin,Na, Duk L.,Kim, Seong Yoon,Lee, Jae-Hong,Han, Seol-Heui,Choi, Seong Hye,Kim, SangYun,Kim, Seonwoo,Carroll, Bernard J.,Kim, Doh Kwan SAGE Publications 2013 Journal of geriatric psychiatry and neurology Vol.26 No.3
<P><B>Background:</B></P><P>Extrapyramidal signs (EPSs) are commonly observed in patients with Alzheimer disease (AD). We report here the base rate of EPS in a large cohort of patients with AD who were not receiving neuroleptic drugs, and the associations of EPS with functional outcomes and depressive symptoms.</P><P><B>Methods:</B></P><P>In a consortium involving 56 clinics, we recruited 2614 patients with AD. We estimated basic activities of daily living (ADL) and instrumental ADL by the Barthel index and the Seoul-Instrumental Activities of Daily Living (S-IADL) scales, respectively. Depressive symptoms were assessed using the 15-item Geriatric Depression Scale (GDS-15). The EPS group was defined by the presence of at least 1 EPS based on a focused neurologic examination.</P><P><B>Results:</B></P><P>The prevalence of EPS-positive patients was 12%. These had lower Korean version of the Mini-Mental State Examination (K-MMSE) scores than the EPS-negative cases (<I>P</I> < .001). After controlling for demographic, medical, radiological, genetic, and cognitive (K-MMSE) factors, the proportion of patients with impaired ADL was significantly higher in the EPS group than in the non-EPS group (<I>P</I> < .001, odds ratio = 1.90, 95% confidence interval, 1.45–2.48, and logistic regression). The S-IADL scores were significantly higher in the EPS group than this in the non-EPS group (<I>P</I> < .001, regression coefficient = 3.19, and median regression). The GDS-15 scores were higher in the EPS group (<I>P</I> = .04, regression coefficient = 0.89, and median regression).</P><P><B>Conclusion:</B></P><P>The presence of EPS in patients with AD who were not receiving neuroleptic drugs was associated with more impaired basic and instrumental ADL functioning and with greater depression symptoms.</P>
Antifungal Activity-Guided Analysis of Actinostemma lobatum Extracts through Serial Sub-fractions
Seonwoo Choi,Song Hee Lee,Byeong Su Hwang,Young Taek Oh,전준현 한국식물병리학회 2024 Plant Pathology Journal Vol.40 No.1
Plants are treasure trove of novel compounds that have potential for antifungal chemicals and drugs. In our previous study, we had screened plant extracts obtained from more than eight hundred plant materials collected in Korea, and found that butanol fraction of the Actinostemma lobatum were most potent in suppressing growth of diverse fungal pathogens of plants. Here in this study, we describe further analysis of the butanol fraction, and summarize the results of subsequent antifungal activity test for the sub-fractions against a selected set of plant pathogenic fungi. This line of analyses allowed us to identify the sub-fractions that could account for a significant proportion of observed antifungal activity of initial butanol fraction from A. lobatum. Further analysis of these sub-fractions and determination of structure would provide the shortlist for novel compounds that can be a lead to new agrochemicals.
최선우(Seonwoo Choi),김주환(Juhwan Kim),최회명(Hoimyung Choi) 한국자동차공학회 2019 한국 자동차공학회논문집 Vol.27 No.3
Drivers have expressed their disappointment with the differences between certified fuel efficiency and real driving fuel efficiency. The extent of the gap between the two types of fuel efficiency has been reported mainly from Europe, so it is necessary to study the gap between the fuel efficiency and certified fuel efficiency of Korean drivers. Therefore, this study recruited Korean drivers and obtained their driving data from the same OBD II terminal. We selected one gasoline vehicle and one diesel vehicle with a large number of drivers and examined the differences among the 4 representative values of the actual fuel efficiency of the driver and the 2016 certified fuel efficiency. The 4 representative values of the actual fuel efficiency of the driver are defined as arithmetic mean, harmonic mean, median value, and mode value according to the statistical method. As a result, certified fuel efficiency is better than the actual fuel efficiency. In the future, we will analyze the gap based on the number of vehicles and different driving conditions.
실 주행 연비 객관화를 위한 새로운 운전자 연비 지수의 정의 및 검증 연구
최선우(Seonwoo Choi),최회명(Hoimyung Choi) 한국자동차공학회 2020 한국 자동차공학회논문집 Vol.28 No.2
As a response to global warming issues in the transport sector, fuel efficiency measures have been improved, and emissions have been restricted. Although the certified fuel efficiency standard is improving, actual fuel efficiency on real road situations is lower than the certified level, and many drivers are dissatisfied because of this gap. The gap between the two fuel efficiency standards is caused by a number of factors, such as the driver’s driving pattern, gradient, weather, and so on. To study the exact gap, an objective index is required to quantify and exclude these factors from actual fuel efficiency, thus, a preceding research related to this study defined the Driver Fuel Efficiency Index. This study verified the Driver Fuel Efficiency Index in the preceding research based on real-road driving data, but it was found that the Driver Fuel Efficiency Index had a lower R2 value than the real fuel consumption rate. Therefore, this study defined the New Driver Fuel Efficiency Index based on driving power, and verified this index based on five-cycle and real-road driving data.
실제 도로 연비 객관화를 위한 운전자 연비 지수 개발 기초 연구
최선우(Seonwoo Choi),최회명(Hoimyung Choi) 한국자동차공학회 2018 한국 자동차공학회논문집 Vol.26 No.3
To reduce the gap between certified fuel efficiency and real-world conditions, related organizations are changing the certification method of fuel consumption. However, if there is no revision in the fuel consumption influence parameters, such as driving behavior, driving environment, and road environment, the gap may still remain. In this study, we defined two driver fuel economy indexes based on driving engine power and constant engine power: the MAW Power Ratio Index through the MAW(Moving Average Window) method and the Constant Driving Index by using the driving energy to revise fuel influence parameters. Based on 5-cycle testing results, we verified the index through a regression analysis of fuel consumption and the driving fuel economy index. We concluded that the driver fuel economy index has reasonable R2. The R2 of the MAW Power Ratio Index is higher at the smaller window size, and the R2 of the Constant Driving Index is within reasonable road limit speed.