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RISS 인기검색어
- 검색키워드
- 저자 : Sayaka Nakashima (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Association between periodontal bacteria and degenerative aortic stenosis: a pilot study
Kataoka, Akihisa,Katagiri, Sayaka,Kawashima, Hideyuki,Nagura, Fukuko,Nara, Yugo,Hioki, Hirofumi,Nakashima, Makoto,Sasaki, Naoki,Hatasa, Masahiro,Maekawa, Shogo,Ohsugi, Yujin,Shiba, Takahiko,Watanabe, Korean Academy of Periodontology 2021 Journal of Periodontal & Implant Science Vol.51 No.4
Purpose: Although several reports have described the relationship between periodontal disease and cardiovascular disease, information about the association between periodontal disease and the progression of degenerative aortic stenosis (AS) is lacking. Therefore, we performed a retrospective, single-center, pilot study to provide insight into this potential association. Methods: Data from 45 consecutive patients (19 men; median age, 83 years) with mild or moderate degenerative aortic stenosis were analyzed for a mean observation period of 3.3±1.9 years. The total amount of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis and titers of serum immunoglobulin G (IgG) against periodontal bacteria and high-sensitivity C-reactive protein (hs-CRP) were evaluated. Aortic valve area (AVA), maximal velocity (Vmax), mean pressure gradient (mean PG), and the Doppler velocity index (DVI) were evaluated. The change in each parameter per year ([Parameter<sub>LATEST</sub>-Parameter<sub>BASELINE</sub>]/Follow-up Years) was calculated from the retrospective follow-up echocardiographic data (baseline vs. the most recently collected data [latest]). Results: No correlation was found between the concentration of periodontopathic bacteria in the saliva and AS status/progression. The anti-P. gingivalis antibody titer in the serum showed a significant positive correlation with AVA and DVI. Additionally, there was a negative correlation between the anti-P. gingivalis IgG antibody titer and mean PG. The hs-CRP concentration showed positive correlations with Vmax and mean PG. Meanwhile, a negative correlation was observed between the anti-P. gingivalis IgG antibody titer and ΔAVA/year and Δmean PG/year. The hs-CRP concentration showed positive correlations with Vmax and mean PG, and it was significantly higher in patients with rapid aortic stenosis progression (ΔAVA/year <-0.1) than in their counterparts. Conclusions: Our results suggest that periodontopathic bacteria such as A. actinomycetemcomitans and P. gingivalis are not directly related to the status/progression of degenerative AS. However, inflammation and a lower immune response may be associated with disease progression.
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Effectiveness of Solution with 5% Detergent for Cleaning Transnasal Esophagogastroduodenoscopy Lens
Yoshinori Komazawa,Mika Yuki,Nobuhiko Fukuba,Yoshiya Kobayashi,Hitomi Ishitobi,Sayaka Nakashima,Makoto Nagaoka,Yoshiko Takahashi,Toshihiro Shizuku 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.2
Background/Aims: Unsedated transnasal esophagogastroduodenoscopy (EGD) is affected by a poor scope lens-cleaning function. We have previously reported good, albeit limited, effects of an oolong tea washing solution; here, we evaluated the effectiveness of a 5%lens cleaning solution for cleaning an EGD lens. Methods: Five percent lens cleaning solution (C), 5% dimethicone solution (D), and distilled water (W) were prepared. Study I:Lenses were soiled with pork grease, washed with each washing solution, and their image quality was judged. Study II: Patients (n=996)scheduled for transnasal EGD were randomly assigned to the C- or W-group. Lens cleanliness level, washing solution volume used,and endoscopist stress due to lens contamination were determined. Results: Study I: The image quality of the lenses washed with (C) was significantly superior. (D) was clinically unsuitable because ofspray nozzle clogging. Study II: Lens cleaning in the C-group was significantly superior (p<0.0001) and the solution volume requiredwas significantly reduced (p<0.0001), while endoscopist stress was also lower (p<0.0001). Conclusions: For transnasal small-caliber EGD, the present 5% lens cleaning solution provided good visibility. It features a highdetergency level and is simple to formulate for therapeutic endoscopy applications, such as endoscopic submucosal dissection.
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