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Santhosh Kumar Nagarajan, Thirumurthy Madhavan 조선대학교 기초과학연구원 2015 조선자연과학논문집 Vol.8 No.3
Corticotropin-releasing actor receptors (CRFRs) activates the hypothalamic pituitary adrenal axis, one of the 2 parts of the fight or flight response to stress. Increased CRH production has is associated with Alzheimer's disease and major depression and hypoglycemia. In this study, we report the important structural and chemical parameters for CRFR inhibitors using the derivatives of 8-substituted-2-aryl-5-alkylaminoquinolines. A 3D QSAR study, Comparative molecular field analysis (CoMFA) was performed. The best predictions were obtained for the best CoMFA model with a q2 of 0.607 with 6 components and r2 of 0.991. The statistical parameters from the generated CoMFA models indicated that the data are well fitted and have high predictive ability. The contour map resulted from the CoMFA models might be helpful in the future designing of novel and more potent CRFR derivatives.
Santhosh Senguttuvan,이장창 한국전산유체공학회 2018 한국전산유체공학회지 Vol.23 No.4
Non-equilibrium condensation during the rapid expansion of steam in turbomachinery affects the flow performance. The latent heat released during the condensation process leads to condensation shock, which decelerates the flow. In the present paper, the numerical modeling of the non-equilibrium condensation in a supersonic nozzle is achieved by solving two transport equations based on the classical nucleation theory corrected for non-isothermal effects as well as the droplet growth law of Hill. The numerical model is successfully validated to be in good agreement with the experimental data. The effect of condensation of the steam in the nozzle is studied by comparing various flow properties of the steam flow with and without condensation. The results show that the exit Mach number of the nozzle is reduced by 13.5%, and that the total temperature at the exit and boundary layer thickness of the flow are increased by 11.5% and 28%, respectively, due to the latent heat released during the condensation process.
Laparoscopic management of median arcuate ligament syndrome: a video vignette
Santhosh Anand,Preethi Mahalingam,Loganathan Jayapal,Siddhesh Suresh,Tasgaonkar Ema 대한내시경로봇외과학회 2024 Journal of Minimally Invasive Surgery Vol.27 No.1
Median arcuate ligament syndrome (MALS) is a rare condition and a diagnosis of exclusion. We present a 30-year-old man, who had postprandial upper abdominal pain and weight loss of 6 kg in 3 months. His gastroscopy and abdominal ultrasound results were both unremarkable. Computed tomographic angiography showed characteristic compression of the celiac artery by thickened median arcuate ligament causing a ‘J’ shaped course of artery with poststenotic dilatation and dilated branches of the celiac artery. The patient underwent laparoscopic release of the median arcuate ligament. The intraoperative blood loss was 20 mL and duration of the procedure was 140 minutes. The patient had an uneventful recovery and was discharged on postoperative day 2. The symptoms subsided 2 months following surgery and he started gaining weight. Laparoscopic division of the median arcuate ligament is a minimally invasive, safe, and effective method to decompress the celiac artery.
Santhosh Kumar Nagarajan and Thirumurthy Madhavan 조선대학교 기초과학연구원 2016 조선자연과학논문집 Vol.9 No.4
Corticotropin-releasing factor receptors (CRFRs) activate the hypothalamic-pituitary-adrenal axis, which is an integral part of the fight or flight response to stress. Increase in CRH level is observed in Alzheimer’s disease and major depression and hypoglycemia. Here, we report on the relevant physicochemical parameters required for the CRFR inhibitors. Comparative molecular similarity indices analysis (CoMSIA) was performed with the derivatives of 8-substituted-2-aryl-5-alkylaminoquinolinesas CRFR inhibitors. The best predictions were obtained for the best CoMSIA model with a q2 of 0.576 with 6 components and r2 of 0.977. The statistical parameters from the generated CoMSIA models indicated that the data are well fitted and have high predictive ability. CoMSIA contour maps could be useful in the designing of more potent and novel CRFR derivatives. Keywords: 3D-QSAR, CoMSIA, CRFR, CRHR
Numerical study of wet-steam flow in Moore nozzles
Santhosh Senguttuvan,이장창 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.10
Wet-steam flow is a two-phase mixture of vapor and tiny liquid droplets that occurs in the final stages of low pressure (LP) steam turbine process. These liquid droplets are formed by the non-equilibrium condensation of steam. This condensation of steam releases a significant amount of latent heat to the flow. As a result, the flow velocity is reduced and it affects the efficiency of the steam turbine. Since it is extremely difficult to perform numerical studies with the non-equilibrium condensation for turbines, they are usually done in convergent-divergent nozzles. In this paper, the effect of area ratio of the well-known Moore nozzles on the non-equilibrium condensation of steam is investigated numerically. The mathematical model for the non-equilibrium condensation is based on the classical homogeneous nucleation theory corrected with non-isothermal effects and Hill’s droplet growth law. The numerical results are successfully validated with the experimental data for Moore nozzle B. The numerical results represent that with increasing area ratio, the intensity of condensation decreases and the residue amount of liquid mass fraction in the flow field increases. Therefore, while designing the area ratio of the nozzle, the influences of both the condensation intensity and liquid mass fraction should be considered.