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Study on Young's Modulus of Geomaterials used in Korean Railway Infrastructures
Lee, Sung Jin,Lee, Seong Hyeok,Lee, Il Wha,Hwang, Su Beom,Kim, Ki Jae The Korean Society for Railway 2013 International Journal of Railway Vol.6 No.2
In this study, cyclic triaxial tests were carried out with the coarse granular materials used in Korean railway infrastructure (reinforced trackbed, gravel of transition zone, upper subgrade of railway) and Young's modulus for the target materials in small strain level were suggested. And the result of elastic modulus suggested in this study is expected to be effectively applied to dynamic analysis of the railway embankment structure using similar material, since the grain size distributions and unit weight of the material tested in this study are specified in Korean Railway Design Criteria.
Lee, Sang-Guk,Yim, Ye Seal,Lee, Yong-ho,Lee, Byung-Wan,Kim, Hyon-Suk,Kim, Kyung-Sup,Lee, Yong-Wha,Kim, Jeong-Ho Elsevier 2018 Diabetes research and clinical practice Vol.140 No.-
<P>Conclusions: The increase in fasting serum AAs can be an early manifestation of insulin resistance. Increased muscle proteolysis induced by insulin resistance and inflammatory cytokines can be a possible mechanism for the rise in serum AA levels. (C) 2018 Elsevier B.V. All rights reserved.</P>
Lee, Juhie,Ban, Ju Yeon,Won, Kyu Yeoun,Kim, Gyo-Yong,Lim, Sung-Jig,Lee, Sun,Kim, Youn Wha,Park, Yong-Koo,Lee, Sang Sook National Hellenic Research Foundation 2008 Oncology reports Vol.20 No.4
<P>This study investigated the useful morphologic and immunophenotypic findings for the diagnosis of Castleman's disease (CD). We focused on the distribution and expression of follicular dendritic cells (FDC) in lymphoid follicles from patients with CD. Eleven CD cases of the hyaline vascular (HV) variant and six cases of the plasma cell (PC) variant were studied using tissue microarray and paraffin resistant monoclonal antibodies CD21, CD35, and EGFR, a new novel marker of FDC, as well as an antibody against human herpes virus 8 (HHV8). Epstein-Barr virus (EBV) was detected by means of in situ hybridization with a fluorescein isothiocyanate-labeled EBV-encoded RNA (EBER) specific oligonucleotide. The FDC network of the PC variant (n=4) was similar to that seen in normal or reactive germinal centers. In contrast, all HV variants and 2 cases of the PC variant were either expanded, disrupted, or exhibited multiple tight collections of FDC both in germinal centers and in mantle zone lymphocytes. The expanded mantle zone lymphocytes were CD20+, Bcl2+, PAX5+, and MUM1- with less number of CD3+ T cells admixed. Other features of the HV variant included follicular regression and vascular ingrowth of the germinal centers, whereas features of the PC variant were follicular hyperplasia and interfollicular plasmacytosis. In addition, EBV infection was positive in three CD cases, and one case had co-expression of HHV8 and EBV infection. Taken together, we found immunophenotypic differences of mantle zone lymphocytes and FDC network patterns of lymphoid follicles in CD. Thus, we conclude that these differences are relevant for the differential diagnosis of the two histopathologic variants of CD.</P>
Lee, Sang Heon,Derby, Richard,Sul, Dong geun,Hong, Jung wha,Kim, Gon Ho,Kang, Seok,Kim, Nack Hwan,Yoo, Seung Han,Lee, Seok Jun,Hong, Young Ki,Lee, Jeong Eun Blackwell Publishing Inc 2011 Pain medicine Vol.12 No.3
<P><B>Abstract</B></P><P><B>Study Design. </B> An institutional, prospective clinical data analysis.</P><P><B>Objective. </B> To evaluate the safety and efficacy of a new navigable percutaneous disc decompression device (L'DISQ) in patients with lumbar disc herniation with radicular pain.</P><P><B>Methods and Outcome Measures. </B> We performed disc decompressions using L'DISQ on 27 patients with persistent disabling back and leg pain for 1 month or longer (average 6.48 months) due to a herniated lumbar intervertebral disc. Baseline data were prospectively gathered before the index procedure and at 1, 4, 12, and 24 weeks post‐procedure. Data included pain intensity (visual analog scale [VAS]), measure of disability (Oswestry Disability Index [ODI] and Rolando–Morris Questionnaire [RM]), health‐related quality of life (Bodily Pain Scale of Short Form‐36 version 2 [SF‐36 BP]), and passive straight leg raising test (SLR).</P><P><B>Results. </B> The VAS fell from 7.08 ± 1.22 to 1.84 ± 0.99 scores at 24 weeks post‐procedure. At 24 weeks, the ODI had fallen from 41.88 ± 10.61 to 16.66 ± 8.55% and the RM from 11.52 ± 3.91 to 2.68 ± 1.97 points. The SF‐36 BP dropped significant improvement from 32.89 ± 5.83 to 49.57 ± 4.96 scales. In the SLR test, the angular change of 24 weeks showed considerable improvement from 60.20 ± 20.02 to 83.00 ± 14.29 degrees. No major complication occurred, although two cases developed a disc reherniation 1 month post‐procedure.</P><P><B>Conclusions. </B> The L'DISQ device is specifically designed to remove herniated disc using a wand that can be navigated into a disc protrusion or extrusion. Following decompression, we measured clinically significant pain improvement and decreased disability for patients with both radicular and axial pain caused by protruded and extruded discs.</P>
Lee, Sang-Jun,Oh, Sumi,Kim, Mi-Ja,Sim, Gun-Sub,Moon, Tae Wha,Lee, JaeHwan The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3
Background: Explosive puffing can induce changes in the chemical, nutritional, and sensory quality of red ginseng. The antioxidant properties of ethanolic extracts of red ginseng and puffed red ginseng were determined in bulk oil and oil-in-water (O/W) emulsions. Methods: Bulk oils were heated at $60^{\circ}C$ and $100^{\circ}C$ and O/W emulsions were treated under riboflavin photosensitization. In vitro antioxidant assays, including 2,2-diphenyl-1-picrylhudrazyl, 2,2'-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid, ferric reducing antioxidant power, total phenolic content, and total flavonoid content, were also performed. Results: The total ginsenoside contents of ethanolic extract from red ginseng and puffed red ginseng were 42.33 mg/g and 49.22 mg/g, respectively. All results from above in vitro antioxidant assays revealed that extracts of puffed red ginseng had significantly higher antioxidant capacities than those of red ginseng (p < 0.05). Generally, extracts of puffed red and red ginseng had high antioxidant properties in riboflavin photosensitized O/W emulsions. However, in bulk oil systems, extracts of puffed red and red ginseng inhibited or accelerated rates of lipid oxidation, depending on treatment temperature and the type of assay used. Conclusion: Although ethanolic extracts of puffed red ginseng showed stronger antioxidant capacities than those of red ginseng when in vitro assays were used, more pro-oxidant properties were observed in bulk oils and O/W emulsions.
Effects of White Radish (Raphanus sativus) Enzyme Extract on Hepatotoxicity
Lee, Sang-Wha,Yang, Kwang-Mo,Kim, Jung-Ki,Nam, Byung-Hyouk,Lee, Chang-Min,Jeong, Min-Ho,Seo, Su-Yeong,Kim, Gi-Yong,Jo, Wol-Soon Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.3
Raphanus sativus (Cruciferaceae), commonly known as radish is widely available throughout the world. From antiquity it has been used in folk medicine as a natural drug against many toxicants. The present study was designed to evaluate the hepatoprotective activity of radish (Raphanus sativus) enzyme extract (REE) in vitro and in vivo test. The $IC_{50}$ values of REE in human liver derived HepG2 cells was over 5,000 ${\mu}g/ml$ in tested maximum concentration. The effect of REE to protect tacrine-induced cytotoxicity in HepG2 cells was evaluated by MTT assay. REE showed their hepatoprotective activities on tacrine-induced cytotoxicity and the $EC_{50}$ value was 1,250 ${\mu}g/ml$. Silymarin, an antihepatotoxic agent used as a positive control exhibited 59.7% hepatoprotective activity at 100 ${\mu}g/ml$. Moreover, we tested the effect of REE on carbon tetrachloride ($CCl_4$)-induced liver toxicity in rats. REE at dose of 50 and 100 mg/kg and silymarin at dose of 50 mg/kg were orally administered to $CCl_4$-treated rats. The results showed that REE and silymarin significantly reduced the elevated levels of serum enzyme markers induced by $CCl_4$. The biochemical data were supported by evaluation with liver histopathology. These findings suggest that REE, can significantly diminish hepatic damage by toxic agent such as tacrine or $CCl_4$.
Lee, Jung Sook,Song, Young Wha,Kim, Sung Won International Academy of Physical Therapy Research 2014 Journal of International Academy of Physical Ther Vol.5 No.2
The cerebellum is known to control balance, equilibrium, and muscle tone. If the cerebellum becomes damaged, the body is unable to retain its balancing functions or involuntary muscle movement. This is why, in stroke patients, there is a high risk of functional disability, as well as a myriad of other disabilities secondary to stroke. Ischemia was induced in SD mice by occluding the common carotid artery for 5 minutes, after which blood was reperfused. Needle electrode electrical stimulation(NEES) was applied to acupuncture points, at 12, 24, and 48 hours post-ischemia on the joksamri. Protein expression was investigated through caspase-3 antibody immuno-reactive cells in the cerebral nerve cells and Western blotting. The results were as follows: The number of caspase-3 reactive cells in the corpus cerebellum 12 and 24 hours post-ischemia was significantly (p<.05) smaller in the NEES group compared to the GI group. caspase-3 expression 12 and 24 hours post-ischemia was significantly(p<.05) smaller in the NEES group compared to the GI group. Based on these results, NEES seems to have a significant effect on Caspase-3 in the cerebellum in an ischemic state at 12 and 24 hours post ischemia, NEES delays the occurrence of early stage apoptosis-inducing Caspase-3, delaying and inhibiting apoptosis. Further systematic studies will have to be conducted in relation to the application of this study's results on stroke patients.
Lee, Min Jae,Kim, Dong Eun,Zakrzewska, Adriana,Yoo, Young Dong,Kim, Su-Hyeon,Kim, Sung Tae,Seo, Jai Wha,Lee, Young Sook,Dorn, Gerald W,Oh, Uhtaek,Kim, Bo Yeon,Kwon, Yong Tae American Society for Biochemistry and Molecular Bi 2012 The Journal of biological chemistry Vol.287 No.28
<P>The N-end rule pathway is a proteolytic system in which destabilizing N-terminal amino acids of short lived proteins are recognized by recognition components (N-recognins) as an essential element of degrons, called N-degrons. In eukaryotes, the major way to generate N-degrons is through arginylation by ATE1 arginyl-tRNA-protein transferases, which transfer Arg from aminoacyl-tRNA to N-terminal Asp and Glu (and Cys as well in mammals). We have shown previously that ATE1-deficient mice die during embryogenesis with defects in cardiac and vascular development. Here, we characterized the arginylation-dependent N-end rule pathway in cardiomyocytes. Our results suggest that the cardiac and vascular defects in ATE1-deficient embryos are independent from each other and cell-autonomous. ATE1-deficient myocardium and cardiomyocytes therein, but not non-cardiomyocytes, showed reduced DNA synthesis and mitotic activity ~24 h before the onset of cardiac and vascular defects at embryonic day 12.5 associated with the impairment in the phospholipase C/PKC-MEK1-ERK axis of Gα(q)-mediated cardiac signaling pathways. Cardiac overexpression of Gα(q) rescued ATE1-deficient embryos from thin myocardium and ventricular septal defect but not from vascular defects, genetically dissecting vascular defects from cardiac defects. The misregulation in cardiovascular signaling can be attributed in part to the failure in hypoxia-sensitive degradation of RGS4, a GTPase-activating protein for Gα(q). This study is the first to characterize the N-end rule pathway in cardiomyocytes and reveals the role of its arginylation branch in Gα(q)-mediated signaling of cardiomyocytes in part through N-degron-based, oxygen-sensitive proteolysis of G-protein regulators.</P>