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Spherical newton distance for oscillatory integrals with homogeneous phase functions
( Sang Hyun Lee ),( Gyu Dong Jo ),( Chul Woo Ryu ),( Young Cha Suh ) 호남수학회 2011 호남수학학술지 Vol.33 No.1
In this paper we study oscillatory integrals with analytic homogeneous phase functions for smooth radial functions. We give their sharp asymptotic behavior in terms of spherical Newton distance.
Sang Baek Ryu,Jang Hee Ye,Chi Hyun Kim,Yong Sook Goo,Kyung Hwan Kim 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
For successful restoration of visual function by a visual neural prosthesis such as retinal implant, electrical stimulation should evoke neural responses so that the information on visual input is properly represented. A stimulation strategy, which means a method for generating stimulation waveforms based on visual input, should be developed for this purpose. We proposed to use the decoding of visual input from retinal ganglion cell (RGC) responses for the evaluation of stimulus encoding strategy. This is based on the assumption that reliable encoding of visual information in RGC responses is required to enable successful visual perception. The main purpose of this study was to determine the influence of inter-dependence among stimulated RGCs activities on decoding accuracy. Light intensity variations were decoded from multiunit RGC spike trains using an optimal linear filter. More accurate decoding was possible when different types of RGCs were used together as input. Decoding accuracy was enhanced with independently firing RGCs compared to synchronously firing RGCs. This implies that stimulation of independently-firing RGCs and RGCs of different types may be beneficial for visual function restoration by retinal prosthesis.
Sang Baek Ryu,Jang Hee Ye,Jong Seung Lee,Yong Sook Goo,Chi Hyun Kim,Kyung Hwan Kim 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.6
For successful visual perception by visual prosthesis using electrical stimulation, it is essential to develop an effective stimulation strategy based on understanding of retinal ganglion cell (RGC) responses to electrical stimulation. We studied RGC responses to repetitive electrical stimulation pulses to develop a stimulation strategy using stimulation pulse frequency modulation. Retinal patches of photoreceptor-degenerated retinas from rd1 mice were attached to a planar multi-electrode array (MEA) and RGC spike trains responding to electrical stimulation pulse trains with various pulse frequencies were observed. RGC responses were strongly dependent on inter-pulse interval when it was varied from 500 to 10 ms. Although the evoked spikes were suppressed with increasing pulse rate, the number of evoked spikes were >60% of the maximal responses when the inter-pulse intervals exceeded 100 ms. Based on this, we investigated the modulation of evoked RGC firing rates while increasing the pulse frequency from 1 to 10 pulses per second (or Hz) to deduce the optimal pulse frequency range for modulation of RGC response strength. RGC response strength monotonically and linearly increased within the stimulation frequency of 1∼9 Hz. The results suggest that the evoked neural activities of RGCs in degenerated retina can be reliably controlled by pulse frequency modulation, and may be used as a stimulation strategy for visual neural prosthesis.
Ryu, Chung-Kyu,Kim, Dong-Hyun,Kwon, Sang-Mee,Jung, Sung-Hee,Kim, Sung-Hee 梨花女子大學校 藥學硏究所 1998 藥學硏究論文集 Vol.- No.7
Antifungal activities of 6-[(N-4-bromophenyl)amino]-7-cholor-5,8-quinolinedione (RCK7) were tested. The MIC values of RCK7 were determined for antifungal suceptibility, in vitro against Aspergillus niger, Cryptococcus neoformans and Trichophyton mentagrophyte by standard agar streak method. In vitro, RCK7 showed more potent antifungal activity than fluconazole and ketoconazole. Also, RCK7 was tested for in vivo antifungal activity in the treatment of systemic infection with Candida albicans in normal mice. The therapeutic potential of RCK7 had been assessed by evaluating their survival rate against systemic infections compared with that of ketoconazole. ED_50 of intraperitoneally administered RCK7 was 2.05±0.30 ㎎/㎏, but that of ketoconazole was 8.00±0.73 ㎎/㎏, respectively. When RCK7 was adminstered in travenously at the ED_50(2.05 ㎎/㎏), the colony of Candida albicans in the liver after 7 days and 14 days were reduced as likely as ketoconazole at the ED_50 (8.00 ㎎/㎏), and the better survival rates than ketoconazole's were achieved after 14 days. The results suggest that RCK7 may be a potent antifungal agent.
Ryu Hyun-Ju,Bae Hanna-Eun-Kyong,Shim June-Sung,Lee Seok-Hyung,Moon Hong-Suk,Chung Mun-Kyu The Korean Academy of Prosthodonitics 2004 대한치과보철학회지 Vol.42 No.6
Statement of Problem. Temporary soft relining materials are used in a diverse clinical situations such as tissue conditioner, relining material, functional impression by varying its viscoelasticity. However, reproduction of consistent viscoelasticity has been not possible. Materials and methods. Considering setting mechanism of this material, this study has measured the effect of varying amount of void in dynamic viscoelasticity of soft relining material, with three different mixing methods. In each methods 10 specimens were made and subjected to dynamic viscoelastic test which were measured at specific times over period of 72 hours. Results. The analysis of the result shown that there was no statistically significant differences between different mixing methods. Conclusion. Different mixing methods had no effect over control of viscoelasticity of soft lining material. Further research is recommended for under similar oral environmental condition.
Afatinib-Induced Acute Fatal Pneumonitis in Metastatic Lung Adenocarcinoma
Sang Hoon Yoo,Jin Ah Ryu,Seo Ree Kim,Su Yun Oh,Gu Sung Jung,Dong Jae Lee,Bong Gyu Kwak,Yu Hyun Nam,Kyung Hyun Kim,Young Jun Yang 대한가정의학회 2016 Korean Journal of Family Medicine Vol.37 No.6
Afatinib is an oral tyrosine kinase inhibitor (TKI) that inhibit Endothelial Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2), and HER4. The common side effects of EGFR TKI are rash, acne, di-arrhea, stomatitis, pruritus, nausea, and loss of appetite. Drug induced pneumonitis is the less common adverse ef-fects of EGFR TKI. Afatinib, 2nd generation EGFR TKI is anticipated to overcome drug resistance from 1st genera-tion EGFR TKI according to preclinical study, and several studies are being conducted to compare clinical efficacy between 1st and 2nd EGFR TKI. Several cases of rug induced acute fatal pneumonitis were reported after use of er-lotinib or gefitinib. However, a case of acute fatal pneumonitis associated with afatinib was note reported except drug induced pneumonitis in other clinical study. Here, we present a cases of acute severe pneumonitis related with afatinib in metastatic lung adenocarcinoma with literature review.