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Single Oral Dose Toxicity Studies of Polycan, b-Glucan Originated from Aureobasidium in Mice
Hyeung-Sik Lee,Kun-Ju Yang,Hyun-Dong Shin,Bok-Ryeon Park,Chang-Woo Son,Hee-Jeong Jang,Dong-Chan Park,Young-Mi Jung,Sae-Kwang Ku 한국독성학회 2005 Toxicological Research Vol.21 No.4
This study was conducted to obtain the acute information of the oral dose toxicity of Polycan - originated from Aureobasidium pullulans SM-2001 (half of the dry material is -1,3/1,6-glucans), a UV induced mutant of A. pullulans, having various pharmacological effects, in male and female mice. In order to calculate 50% lethal dose (LD50), approximate LD and target organs, test article was administered twice by oral gavage to male and female ICR mice at total 1000, 500 and 250 mg/kg. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings. The results obtained in this study suggest that the Polycan is non-toxic in mice and is therefore likely to be safe for clinical use. The LD50 and approximate LD in mice after single oral dose of Polycan were considered over 1000 mg/kg, respectively.
Single Oral Dose Toxicity Studies of Polycan, β-Glucan Originated from Aureobasidium in Mice
Hyeung-Sik Lee,Kun-Ju Yang,Hyun-Dong Shin,Bok-Ryeon Park,Chang-Woo Son,Hee-Jeong Jang,Dong-Chan Park,Young-Mi Jung,Sae-Kwang Ku 한국독성학회 2005 Toxicological Research Vol.21 No.4
This study was conducted to obtain the acute information of the oral dose toxicity of Polycan - originated from Aureobasidium pullulans SM-2001 (half of the dry material is -1,/1,6-glucans), a UV induced mutant of A. pullulans, having various pharmacological effects, in male and female mice. In order to calculate 50% lethal dose (LD_(50)), approximate LD and target organs, test article was administered twice by oral gavage to male and female ICR mice at total 1000, 500 and 250 ㎎/㎏. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings. The results obtained in this study suggest that the Polycan is non-toxic in mice and is therefore likely to be safe for clinical use. The LD_(50) and approximate LD in mice after single oral dose of Polycan were considered over 1000 ㎎/㎏, respectively.
Single Oral Dose Toxicity Studies of Polycan, β-Glucan Originated from Aureobasidium in Mice
Lee, Hyeung-Sik,Yang, Kun-Ju,Shin, Hyun-Dong,Park, Bok-Ryeon,Son, Chang-Woo,Jang, Hee-Jeong,Park, Dong-Chan,Jung, Young-Mi,Ku, Sae-Kwang Korean Society of ToxicologyKorea Environmental Mu 2005 Toxicological Research Vol.21 No.4
This study was conducted to obtain the acute information of the oral dose toxicity of Polycan - originated from Aureobasidium pullulans SM-2001 (half of the dry material is -1,3/1,6-glucans), a UV induced mutant of A. pullulans, having various pharmacological effects, in male and female mice. In order to calculate $50\%$ lethal dose $(LD_{50})$, approximate LD and target organs, test article was administered twice by oral gavage to male and female ICR mice at total 1000, 500 and 250mg/kg. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings. The results obtained in this study suggest that the Polycan is non-toxic in mice and is therefore likely to be safe for clinical use. The L050 and approximate $(LD_{50})$ in mice after single oral dose of Polycan were considered over 1000 mg/kg, respectively.
Lee, Hyeung-Sik,Cho, Hyung-Rae,Yang, Kun-Ju,Moon, Seung-Bae,Park, Bok-Ryeon,Shin, Hyun-Dong,Jang, Hee-Jeong,Kim, Lin-Su,Ku, Sae-Kwang Korean Society of ToxicologyKorea Environmental Mu 2008 Toxicological Research Vol. No.
In this research the genotoxic effect of $Polycan^{TM}$ ${\beta}$-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. $Polycan^{TM}$ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that $Polycan^{TM}$ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of $Polycan^{TM}$ tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups.
Local Irritation Test of 3 Types of β-Glucan after Subcutaneous Injection in Rats
Hyeung-Sik Lee,Hyung-Rae Cho,Kun-Ju Yang,Hyun-Dong Shin,Bok-Ryeon Park,Hee-Jeong Jang,Kwang-Ho Cho,Hyeong-Dong Kim,Sae-Kwang Ku 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.4
The objective of the present study is to detect the potency of skin irritation of 3 types of β-glucan: Polycan, Tinocare GL and SC-glucan, after a subcutaneous injection at 2 g/㎏, respectively. Test articles were given single subcutaneous injection at the shaving back of rat one point per rat and they were sacrificed at 7 days after injection. Histopathological changes on the injection sites were observed with histomorphometry, the thickness of encapsulation and percentages of collagenous tissues in encapsulation regions. As results of subcutaneous injection of all three types of β-glucan, encapsulations consisted of inflammatory cells and connective tissues caused by skin irritation and foreign body reactions, were observed with microangiogenesis restricted to the injection sites. The most severe histopathological changes were detected in the SC-glucan and then in order of Tinocare GL and Polycan. Therefore, it is considered that the potency of the skin irritant caused by β-glucan is quite differed from their origin and they showed relatively lower irritation because the changes related to the irritation and foreign body reactions were restricted to the injection sites. Among three types of β-glucan tested in the present study, Polycan showed the lowest irritation and SC-glucan showed the highest skin irritation.
Hyeung-Sik Lee,Hyung-Rae Cho,Kun-Ju Yang,Seung-Bae Moon,Bok-Ryeon Park,Hyun-Dong Shin,Hee-Jeong Jang,Lin-Su Kim,Sae-Kwang Ku 한국독성학회 2008 Toxicological Research Vol.24 No.1
In this research the genotoxic effect of Polycan™ β-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. Polycan™ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that Polycan™ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of Polycan™ tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups.
최규석,신세건,최길현,김문걸,Kyu Suck Choi,Sae Kun Shin,Kil Hyun Choi,Mun Kul Kim 대한화학회 1977 대한화학회지 Vol.21 No.1
m-Phenylenediamine(以下 MPD로 略함)과 resorcinol(以下 RES로 略함)을 몰比를 달리하면서 포름알데히드와 酸化觸媒 존재하에서 反應시켜 生成되는 附加共縮合型 樹脂를 流動파라핀을 사용하여 서스펜젼重合시켜 60∼80 mesh의 粒狀重合體를 合成하고 이를 精製한후 5, 10, 15, 20, $25{\%}$의 水酸化 나트륨 水溶液으로 처리한후, 原樹脂와 이들 알칼리 處理樹脂의 金屬이온들에 대한 吸着性을 檢討하였다. $Cd^{2+}$이온에 대한 흡착성은 原樹脂보다 水酸化나트륨水溶液을 처리한 경우 현저히 吸着性은 向上되지만 MPD : RES의 몰比 가 增加함에 따라 原樹脂의 경우와는 달리 減少하는 경향을 나타내며 $Pb^{2+}와\;Al^{3+}$이온들은 알칼리처리로 吸着能增加와 더불어 MPD : RES의 몰比가 2 : 1에서 最大値를 나타내며 $Ca^{2+}$이온의 경우는 MPD : RES의 몰比가 1 : 1에서 최대치를 나타내고 있다. $Mg^{2+}과\;Co^{2+}$이온들은 거의 類似한 傾向을 나타내어 MPD : RES의 몰比增加와 더불어 吸着能은 減少하는 傾向을 나타낸다. $Hg^{2+}$이온의 경우는 特異하며 MPD : RES의 몰比가 減少함에 따라 吸着能은 현저히 增加하는 경향을 나타내어 窒素含宥킬레이트와의 結合性이 强한 一般性과 잘 一致하고 있다. 이 系의 樹脂들은 輕金屬 이온(例 $Ca^{2+},\;Mg^{2+}$) 들보다 重金屬이온(例 $Cd^{2+},\;Hg^{2+}$)들에 對한 吸着力이 현저히 優秀하다. In the addition condensation reaction of m-phenylenediamine(MPD) and resorcinol (RES) with formaldehyde, the suspension polymerization in liquid paraffin was performed and the bead polymers were obtained with good results. The polymers were treated with dilute aqueous sodium hydroxide solutions in order to improve the adsorption capacity to the metallic ions and the adsorptivity to the several metallic ions, such as $Cd^{2+},\;Pb^{2+},\;Al^{3+},\;Mg^{2+},\;Co^{2+},\;and\;Hg^{2+}$ of the alkali-treated and untreated polymers were tested. These MPD-RES-F type resins showed better adsorption capacity to the heavy metallic ions such as $Cd^{2+}\;and\;Hg^{2+}$ than the light metallic ions such as $Pb^{2+},\;Al^{3+}\;and\;Mg^{2+}$, and the treatment of the resins with about 20 percent aqueous sodium hydroxide solution showed significant improvement of the adsorption capacity to the metallic ions in all cases.