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김재원,Atsushi Tamura,Sachiko Tsukita,박성수 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-
Immature cell monolayers are vulnerable to tensile strain, which can cause severe diseases includingfibrosis, cancer, and atherosclerosis. However, little is known about how immature cell monolayersrespond to tensile strain. To study the effect of tensile strain on the morphology of cells in immaturemonolayers, we developed a miniaturized stretching device that allows stable real-time imaging ofchanges in cell shape induced by uniaxial static stretching of up to 20%. Upon stretching, the shape of cellsin the immature (2 day-cultured) monolayer changed dynamically, unlike in the mature (7 day-cultured)monolayer. Dynamic changes in the immature cell monolayers induced by tensile strain can be explainedby the increase in di-phosphorylated myosin light chain (pp-MLC), which initiates actomyosincontraction. We suggest that our stretching-observation system can be used to investigate themorphological response of epithelial cell monolayers to tensile strain.