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ZNF509S1 downregulates PUMA by inhibiting p53K382 acetylation and p53-DNA binding
Jeon, B.N.,Yoon, J.H.,Han, D.,Kim, M.K.,Kim, Y.,Choi, S.H.,Song, J.,Kim, K.S.,Kim, K.,Hur, M.W. Elsevier Science 2017 Biochimica et biophysica acta. Gene regulatory mec Vol.1860 No.9
Expression of the POK family protein ZNF509L, and -its S1 isoform, is induced by p53 upon exposure to genotoxic stress. Due to alternative splicing of the ZNF509 primary transcript, ZNF509S1 lacks the 6 zinc-fingers and C-terminus of ZNF509L, resulting in only one zinc-finger. ZNF509L and -S1 inhibit cell proliferation by activating p21/CDKN1A and RB transcription, respectively. When cells are exposed to severe DNA damage, p53 activates PUMA (p53-upregulated modulator of apoptosis) transcription. Interestingly, apoptosis due to transcriptional activation of PUMA by p53 is attenuated by ZNF509S1. Thus we investigated the molecular mechanism(s) underlying the transcriptional attenuation and anti-apoptotic effects of ZNF509S1. We show that ZNF509S1 modulation of p53 activity is important in PUMA gene transcription by modulating post-translational modification of p53 by p300. ZNF509S1 directly interacts with p53 and inhibits p300-mediated acetylation of p53 lysine K382, with deacetylation of p53 K382 leading to decreased DNA binding at the p53 response element 1 of the PUMA promoter. ZNF509S1 may play a role not only in cell cycle arrest, by activating RB expression, but also in rescuing cells from apoptotic death by repressing PUMA expression in cells exposed to severe DNA damage.
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Progression of primary open angle glaucoma in asymmetrically myopic eyes
Song, M. K.,Sung, K. R.,Han, S.,Lee, J. E.,Yoon, J. Y.,Park, J. M.,Lee, J. Y. Springer Science + Business Media 2016 Graefe's archive for clinical and experimental oph Vol.254 No.7
<P>To compare progression of primary open angle glaucoma (POAG) in asymmetrically myopic eyes within the same subject and evaluate whether the degree of myopia is related to glaucoma progression. POAG patients with asymmetric myopia (axial length [AXL] a parts per thousand yen24 mm in both eyes, and the AXL difference between the right and left eyes to be a parts per thousand yen0.5 mm) were included. Glaucoma progression was determined either by optic disc/retinal nerve fiber layer (RNFL) photographs or by serial visual field (VF) data. The progression rates of VF mean deviation (dB/year) and spectral domain optical coherence tomography measured RNFL thickness (mu m/year) were compared between the more myopic eye (MME) and the less myopic eye (LME) within the same subject. A total of 55 patients (mean follow up period; 4.5 +/- 1.0 years) were included. The mean AXL demonstrated a significant difference between MME and LME (26.3 +/- 1.7 vs. 25.6 +/- 1.7 mm; p = 0.036). The mean baseline VF MD (-3.8 +/- 5.4 vs. -2.6 +/- 4.7 dB; p = 0.21) and average RNFL thickness (77.5 +/- 10.6 vs. 79.9 +/- 12.3 mu m; p = 0.36) did not differ between the MME and LME. Among the 55 patients, optic disc/RNFL photographic progression was noted in the MME in 15 patients, in the LME in 19 patients, and in both eyes in seven patients. VF progression was noted in the MME in seven patients, in the LME in seven patients, and in both eyes in four patients. The VF MD progression rates were -0.25 +/- 0.34 dB/year in MME and -0.26 +/- 0.34 dB/year in LME cases (p = 0.91). The mean progression rate of the average RNFL thickness also did not differ between the MME and LME (-0.59 +/- 0.67 vs. -0.66 +/- 0.72 mu m/year, p = 0.68). The degree of myopia was not associated with glaucoma progression when assessing the same patient using either the VF or optic disc/RNFL criteria in asymmetrically myopic patients.</P>
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Yoon, W.,Park, Y.C.,Kim, J.,Chae, Y.S.,Byeon, J.H.,Min, S.H.,Park, S.,Yoo, Y.,Park, Y.K.,Kim, B.M. Pergamon Press 2017 European journal of cancer Vol.70 No.-
Salmonella have been experimentally used as anti-cancer agents, because they show selective growth in tumours. In this study, we genetically modified attenuated Salmonella typhimurium to express and secrete interferon-gamma (IFN-γ) as a tumouricidal agent to enhance the therapeutic efficacy of Salmonella. IFN-γ was fused to the N-terminal region (residues 1-160) of SipB (SipB160) for secretion from bacterial cells. Attenuated S. typhimurium expressing recombinant IFN-γ (S. typhimurium (IFN-γ)) invaded the melanoma cells and induced cytotoxicity. Subcutaneous administration of S. typhimurium (IFN-γ) also efficiently inhibited tumour growth and prolonged the survival of C57BL/6 mice bearing B16F10 melanoma compared with administration of phosphate-buffered saline (PBS), unmodified S. typhimurium or S. typhimurium expressing empty vector (S. typhimurium [Vec]) in a natural killer (NK) cell-dependent manner. Moreover, genetically modified Salmonella, including S. typhimurium (IFN-γ), showed little toxicity to normal tissues with no observable adverse effects. However, S. typhimurium (IFN-γ)-mediated tumour suppression was attributed to direct killing of tumour cells rather than to stable anti-tumour immunity. Collectively, these results suggest that tumour-targeted therapy using S. typhimurium (IFN-γ) has potential for melanoma treatment.
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Yoon, S. S.,Kim, H. Y.,Hewson, J. C.,Suo-Anttila, J. M.,Glaze, D. J.,DesJardin, P. E. M. Dekker 2007 Drying technology Vol.25 No.6
<P> One new technology for fire suppressant distribution in total-flooding applications is the solid-propellant gas-generator (SPGG) technology. This article presents experimental and modeling studies of one such prototype system in order to better understand observations in the testing of this system. This particular SPGG system generates fine particles that act to suppress any fire in conjunction with inert gases also generated in the SPGG system. Initial conditions for the simulations are obtained from the available measurements of the prototype system. The modeling provides key information related to the distribution of the particles and their potential effectiveness as a fire suppressant. The primary variable in the SPGG design as identified in the initial measurements, also presented here, was the particle size, with typical particle sizes being measured at 2 and 15 µm. The key modeling result is that there is a tradeoff between the most uniform distribution of particles and the available surface-to-volume ratio for chemical suppression. Information is also provided regarding the thermal dissipation from the SPGG system.</P>
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Yoon, M.Y.,Kim, Y.S.,Ryu, S.Y.,Choi, G.J.,Choi, Y.H.,Jang, K.S.,Cha, B.,Han, S.S.,Kim, J.C. Academic Press 2011 Pesticide biochemistry and physiology Vol.101 No.2
Blast is considered the most important fungal disease of rice due to its wide distribution and destructiveness under favorable conditions. Development of new effective and environmentally benign agents against the causal pathogen, Magnaporthe oryzae, is of great interest. In the course of a search for natural antifungal compounds in medicinal plants, we found that the methanol extract of Angelica gigas roots showed a potent control efficacy against rice blast caused by M. oryzae. We isolated antifungal coumarins from the extract, and they were identified as decursin and decursinol angelate. Antifungal activities of these compounds, along with kasugamycin, were tested on M. oryzae in vivo and in vitro. In an in vivo assay, the three compounds effectively suppressed the development of rice blast at concentrations more than 100μg/mL. Coumarins showed relatively weak inhibitory effect on fungal mycelial growth when compared to kasugamycin. However, they strongly inhibited M. oryzae spore germination, which was not observed in kasugamycin treatments. This is the first report demonstrating that decursinol angelate can provide control against rice blast and that the two coumarins inhibit M. oryzae spore germination. In addition, the wettable powder formulation of the crude extract of A. gigas prohibited the development of blast symptoms on rice plants more effectively than liquid concentrate formulation of kasugamin, a commercial fungicide. Based on our study, we propose that coumarin compounds as well as the A. gigas root crude extract can be used as natural, benign fungicides for controlling rice blast.
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Lim, S.,Lee, M.,Lee, G.,Kim, S.,Yoon, S.,Kang, K. Copernicus GmbH 2012 Atmospheric Chemistry and Physics Vol.12 No.4
<P>Abstract. PM1.0, PM2.5, and PM10 were sampled at Gosan ABC Superstation on Jeju Island from August 2007 to September 2008. The carbonaceous aerosols were quantified with the thermal/optical reflectance (TOR) method, which produced five organic carbon (OC) fractions, OC1, OC2, OC3, OC4, and pyrolyzed organic carbon (OP), and three elemental carbon (EC) fractions, EC1, EC2, and EC3. The mean mass concentrations of PM1.0, PM2.5, and PM10 were 13.7 μg m−3, 17.2 μg m−3, and 28.4 μg m−3, respectively. The averaged mass fractions of OC and EC were 23.0% and 10.4% for PM1.0, 22.9% and 9.8% for PM2.5, and 16.4% and 6.0% for PM10. Among the OC and EC sub-components, OC2 and EC2+3 were enriched in the fine mode, but OC3 and OC4 in the coarse mode. The filter-based PM1.0 EC agreed well with black carbon (BC) measured by an Aethalometer, and PM10 EC was higher than BC, implying less light absorption by larger particles. EC was well correlated with sulfate, resulting in good relationships of sulfate with both aerosol scattering coefficient measured by Nephelometer and BC concentration. Our measurements of EC confirmed the definition of EC1 as char-EC emitted from smoldering combustion and EC2+3 as soot-EC generated from higher-temperature combustion such as motor vehicle exhaust and coal combustion (Han et al., 2010). In particular, EC1 was strongly correlated with potassium, a traditional biomass burning indicator, except during the summer, when the ratio of EC1 to EC2+3 was the lowest. We also found the ratios of major chemical species to be a useful tool to constrain the main sources of aerosols, by which the five air masses were well distinguished: Siberia, Beijing, Shanghai, Yellow Sea, and East Sea types. Except Siberian air, the continental background of the study region, Beijing plumes showed the highest EC1 (and OP) to sulfate ratio, which implies that this air mass had the highest net warming by aerosols of the four air masses. Shanghai-type air, which was heavily influenced by southern China, showed the highest sulfate enhancement. The highest EC2+3/EC1 ratio was found in aged East Sea air, demonstrating a significant influence of motor vehicle emissions from South Korea and Japan and less influence from industrial regions of China. The high ratio results from the longer residence time and less sensitivity to wet scavenging of EC2+3 compared to EC1, indicating that soot-EC could have greater consequence in regional-scale warming. </P>
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윤성운(S. YOON),이상일(S. LEE),박미정(M. J. PARK),손창욱(C. W. SOHN),최용준(Y. CHOI),유정현(J. YOO),Lingxue JIN,김무상(M. KIM),김도균(D. KIM),기태경(T. KI),서미경(M. K. SEO),진민성(M. S. JIN) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
RAON, a heavy ion superconducting linear accelerator has been installed in Daejeon, S. Korea. A cryogenic system, which was installed and tested its performance cool the accelerator down until 269 K. The system consists of a lot of components, cryogenic plants, a distribution box, cryogenic distribution lines, cryomodules and valve boxes. A cryogenic control system which is complicated and integrated by EPICS (Experimental Physics and Industrial Control System) is developed and the graphic user interface which is designed by CS-studio (Control System-studio) is developed. They were verified during the accelerator cool-down but they need some modification based on the cool-down operation. This paper summarizes the RAON cryogenic system infrastructure and graphic user interfaces.
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Kim, S.C.,Kim, S.M.,Yoon, G.J.,Nam, S.W.,Lee, S.Y.,Kim, J.W. Elsevier 2014 CURRENT APPLIED PHYSICS Vol.14 No.suppl2
A solution plasma process was established for fabrication of gelatin-based sponge incorporated with Ag nanoparticles (AgNPs) in this study. Without using any chemical reducing agent, colloidal AgNPs were formed in gelatin medium via the reduction reaction of Ag precursors (AgNO<SUB>3</SUB>) and the hydrogen radicals generated during discharge. The gelatin/AgNPs sponges fabricated by lyophilization had a 3D scaffold structure of micropores with diameters of about 20 μm. TEM analysis showed that the spherical AgNPs in the thin layer of gelatin were evenly well dispersed and had mean particle sizes of about 10-15 nm. The gelatin/AgNP solutions and sponges prepared in this study exhibited excellent bactericidal activity against two well-known bacteria, Escherichia coli and Staphylococcus aureus. All of them inhibited growth of E. coli more efficiently than that of S. aureus. Minimal inhibition concentration of gelatin/AgNP formed with 3% gelatin and 5 mM AgNO<SUB>3</SUB> was <20 and 40 μg/ml for E. coli and S. aureus, respectively. The sponge of 3% gelatin and 5 mM AgNO<SUB>3</SUB> discharged for 740 s showed the strongest bactericidal activity toward both bacteria.
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