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Thakker, Shalin,Biradar, S.M.,Habbu, P.V.,Mahadevan, K.M.,Thippeswamy, B.S.,Veerapur, V.P. Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.4
The present study was undertaken to evaluate the protective effect of ethanol (EtAS), ethyl acetate (EAAS) and aqueous (AQAS) extracts of Argyreia speciosa (AS) roots against Isoproterenol (ISO)-induced myocardial infarction in rats. The animals were exposed to isoproterenol (200 mg/kg. s.c) twice at an interval of 24 hrs. Cardioprotective effect was assessed by observing ECG parameters, serum marker enzymes and histopathology of the heart. Pretreatment of EAAS, and EtAS (200 mg/kg) resulted in a significant (P < 0.001) increase in P wave, QRS complex and R-R interval, whereas heart rate, QT interval and cardiac cycle were maintained near to normal values. EtAS and EAAS showed significant (P < 0.05; P < 0.001) reduction in all the tested diagnostic markers compared to ISO treated group. Histological studies on the structural changes of heart tissue supported the protective activity of AS. The result suggest that treatment of AS prior to ISO has a significant role in protecting the animals from ISO induced myocardial infarction.
Rajkumar, M.,Mahadevan, K.,Kannan, S.,Baskar, S. The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.2
Non-dominated Sorting Genetic Algorithm-II (NSGA-II) is applied for solving Combined Economic Emission Dispatch (CEED) problem with valve-point loading of thermal generators. This CEED problem with valve-point loading is a nonlinear, constrained multi-objective optimization problem, with power balance and generator capacity constraints. The valve-point loading introduce ripples in the input-output characteristics of generating units and make the CEED problem as a nonsmooth optimization problem. To validate its effectiveness of NSGA-II, two benchmark test systems, IEEE 30-bus and IEEE 118-bus systems are considered. To compare the Pareto-front obtained using NSGA-II, reference Pareto-front is generated using multiple runs of Real Coded Genetic Algorithm (RCGA) with weighted sum of objectives. Comparison with other optimization techniques showed the superiority of the NSGA-II approach and confirmed its potential for solving the CEED problem. Numerical results show that NSGA-II algorithm can provide Pareto-front in a single run with good diversity and convergence. An approach based on Technique for Ordering Preferences by Similarity to Ideal Solution (TOPSIS) is applied on non-dominated solutions obtained to determine Best Compromise Solution (BCS).
M. Zubairuddin,S. K. Albert,S. Mahadevan,M. Vasudevan,V. Chaudhari,V. K. Suri 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.12
In this paper, investigation of residual stress and distortion induced in 3 mm thick Modified 9Cr-1Mo steel plates during GTA weldingis carried out. SYSWELD software is used for the thermo-mechanical analysis. A 3D meshed model is created for the simulation anddouble ellipsoidal heat source distribution is used for the thermal analysis. Thermal cycles predicted near the fusion zone are comparedwith experimentally measured thermal cycles using thermocouples. Predicted residual stress profile across the fusion zone is comparedwith the measured profile using X-ray diffraction method. There is a good agreement between measured and predicted thermal cyclesand residual stress profile. Distortion of the weld joint is measured using vertical electronic height gauge. Finite element analysis of distortionof the weld joint is carried out by applying both large and small distortion theories. Comparison of experimental and numericalresults showed better accuracy if large distortion theory is applied.
Rajkumar, M.,Mahadevan, K.,Kannan, S.,Baskar, S. The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.3
This paper discusses the application of evolutionary multi-objective optimization algorithms namely Non-dominated Sorting Genetic Algorithm-II (NSGA-II) and Modified NSGA-II (MNSGA-II) for solving the Combined Economic Emission Dispatch (CEED) problem with valve-point loading. The valve-point loading introduce ripples in the input-output characteristics of generating units and make the CEED problem as a non-smooth optimization problem. IEEE 57-bus and IEEE 118-bus systems are taken to validate its effectiveness of NSGA-II and MNSGA-II. To compare the Pareto-front obtained using NSGA-II and MNSGA-II, reference Pareto-front is generated using multiple runs of Real Coded Genetic Algorithm (RCGA) with weighted sum of objectives. Furthermore, three different performance metrics such as convergence, diversity and Inverted Generational Distance (IGD) are calculated for evaluating the closeness of obtained Pareto-fronts. Numerical results reveal that MNSGA-II algorithm performs better than NSGA-II algorithm to solve the CEED problem effectively.
Shalin Thakker,S M Biradar,PV Habbu,KM Mahadevan,BS Thippeswamy,VP Veerapur 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.4
The present study was undertaken to evaluate the protective effect of ethanol (EtAS), ethyl acetate (EAAS) and aqueous (AQAS) extracts of Argyreia speciosa (AS) roots against Isoproterenol (ISO)-induced myocardial infarction in rats. The animals were exposed to isoproterenol (200 mg/kg. s.c) twice at an interval of 24 hrs. Cardioprotective effect was assessed by observing ECG parameters, serum marker enzymes and histopathology of the heart. Pretreatment of EAAS, and EtAS (200 mg/kg) resulted in a significant (P < 0.001) increase in P wave, QRS complex and R-R interval, whereas heart rate, QT interval and cardiac cycle were maintained near to normal values. EtAS and EAAS showed significant (P < 0.05; P < 0.001) reduction in all the tested diagnostic markers compared to ISO treated group. Histological studies on the structural changes of heart tissue supported the protective activity of AS. The result suggest that treatment of AS prior to ISO has a significant role in protecting the animals from ISO induced myocardial infarction.
Rampriya, B.,Mahadevan, K.,Kannan, S. The Korean Institute of Electrical Engineers 2012 Journal of Electrical Engineering & Technology Vol.7 No.5
This paper presents the application of Differential Evolution (DE) algorithm to obtain a solution for Bid Based Dynamic Economic Dispatch (BBDED) problem including the transmission losses and to maximize the social profit in a deregulated power system. The IEEE-30 bus test system with six generators, two customers and two trading periods are considered under various bidding strategies in a day-ahead electricity market. By matching the bids received from supplying and distributing entities, the Independent System Operator (ISO) maximize the social profit, (with the choices available). The simulation results of DE are compared with the results of Particle swarm optimization (PSO). The results demonstrate the potential of DE algorithm and show its effectiveness to solve BBDED.
B. Rampriya,K. Mahadevan,S. Kannan 대한전기학회 2012 Journal of Electrical Engineering & Technology Vol.7 No.5
This paper presents the application of Differential Evolution (DE) algorithm to obtain a solution for Bid Based Dynamic Economic Dispatch (BBDED) problem including the transmission losses and to maximize the social profit in a deregulated power system. The IEEE-30 bus test system with six generators, two customers and two trading periods are considered under various bidding strategies in a day-ahead electricity market. By matching the bids received from supplying and distributing entities, the Independent System Operator (ISO) maximize the social profit, (with the choices available). The simulation results of DE are compared with the results of Particle swarm optimization (PSO). The results demonstrate the potential of DE algorithm and show its effectiveness to solve BBDED.
M. Rajkumar,K. Mahadevan,S. Kannan,S. Baskar 대한전기학회 2013 Journal of Electrical Engineering & Technology Vol.8 No.3
This paper discusses the application of evolutionary multi-objective optimization algorithms namely Non-dominated Sorting Genetic Algorithm-II (NSGA-II) and Modified NSGA-II (MNSGA-II) for solving the Combined Economic Emission Dispatch (CEED) problem with valvepoint loading. The valve-point loading introduce ripples in the input-output characteristics of generating units and make the CEED problem as a non-smooth optimization problem. IEEE 57-bus and IEEE 118-bus systems are taken to validate its effectiveness of NSGA-II and MNSGA-II. To compare the Pareto-front obtained using NSGA-II and MNSGA-II, reference Pareto-front is generated using multiple runs of Real Coded Genetic Algorithm (RCGA) with weighted sum of objectives. Furthermore, three different performance metrics such as convergence, diversity and Inverted Generational Distance (IGD) are calculated for evaluating the closeness of obtained Pareto-fronts. Numerical results reveal that MNSGA-II algorithm performs better than NSGA-II algorithm to solve the CEED problem effectively.
M. Rajkumar,K. Mahadevan,S. Kannan,S. Baskar 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.2
Non-dominated Sorting Genetic Algorithm-II (NSGA-II) is applied for solving Combined Economic Emission Dispatch (CEED) problem with valve-point loading of thermal generators. This CEED problem with valve-point loading is a nonlinear, constrained multi-objective optimization problem, with power balance and generator capacity constraints. The valve-point loading introduce ripples in the input-output characteristics of generating units and make the CEED problem as a nonsmooth optimization problem. To validate its effectiveness of NSGA-II, two benchmark test systems, IEEE 30-bus and IEEE 118-bus systems are considered. To compare the Pareto-front obtained using NSGA-II, reference Pareto-front is generated using multiple runs of Real Coded Genetic Algorithm (RCGA) with weighted sum of objectives. Comparison with other optimization techniques showed the superiority of the NSGA-II approach and confirmed its potential for solving the CEED problem. Numerical results show that NSGA-II algorithm can provide Pareto-front in a single run with good diversity and convergence. An approach based on Technique for Ordering Preferences by Similarity to Ideal Solution (TOPSIS) is applied on non-dominated solutions obtained to determine Best Compromise Solution (BCS).
( Ravinder K Mittal ),( Geoff Sheean ),( Bikram S Padda ),( Mahadevan R Rajasekaran ) 대한소화기기능성질환·운동학회 2014 Journal of Neurogastroenterology and Motility (JNM Vol.20 No.4
Background/Aims External anal sphincter (EAS) and puborectalis muscle (PRM) play important role in anal continence function. Based on length-tension measurement, we recently reported that the human EAS muscle operates at short sarcomere length under physiological conditions. Goal of our study was to determine if PRM also operates at the short sarcomere length. Methods Length-tension relationship of the PRM muscle was studied in vivo in 10 healthy nullipara women. Length was altered by vaginal distension using custom-designed probes of 5, 10, 15, 20, 25 and 30 mm diameters as well as by distending a polyethylene bag with different volumes of water. Probes were equipped with a reverse perfuse sleeve sensor to measure vaginal pressure (surrogate of PRM tension). PRM electromyogram (EMG) was recorded using wire electrodes. Three-dimensional ultrasound images were obtained to determine effect of vaginal distension on PRM length. Results Ultrasound images demonstrate distension volume dependent increase in PRM length. Rest and squeeze pressures of vaginal bag increased with the increase in bag volume. Similarly, the change in vaginal pressure, which represents the PRM contraction increased with the increase in the probe size. Increase in probe size was not associated with an increase in EMG activity (a marker of neural drive) of the PRM. Conclusions Probe size dependent increase in PRM contraction pressure, in the presence of constant EMG (neural input) proves that the human PRM operates at short sarcomere length. Surgically adjusting the PRM length may represent a novel strategy to improve treat anal continence and possibly other pelvic floor disorders.