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RISS 인기검색어
- 검색키워드
- 저자 : S. D. Koester (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Development of a Novel Imaging Agent for Determining Albumin Uptake in Solid Tumors
S. Daum,J. P. Magnusson,L. Pes,J. Garcia Fernandez,S. Chercheja,F. Medda,F. I. Nollmann,S. D. Koester,P. Perez Galan,A. Warnecke,K. Abu Ajaj,Felix Kratz 대한핵의학회 2019 핵의학 분자영상 Vol.53 No.3
Purpose The purpose of this study was to investigate the albumin-binding compound 111In-C4-DTPA as an imaging agent for the detection of endogenous albumin accumulation in tumors. Methods 111In-C4-DTPA was injected in healthy nude mice for pharmacokinetic and biodistribution studies (10 min, 1, 6, 24, and 48 h, n = 4) and subsequently in tumor-bearing mice for single-photon emission computed tomography/X-ray-computed tomography (SPECT/CT) imaging studies. Four different human tumor xenograft models (LXFL529, OVXF899, MAXFTN401, and CXF2081) were implanted subcutaneously unilaterally or bilaterally (n = 4–8). After intravenous administration of 111In-C4-DTPA, SPECT/CT images were collected over 72 h at 4–6 time points. Additionally, gamma counting was performed for the blood, plasma, lungs, heart, liver, spleen, kidneys, muscle, and tumors at 72 h post-injection. Results 111In-C4-DTPA bound rapidly to circulating albumin upon injection, and the radiolabeled albumin conjugate thus formed was stable in murine and human serum. SPECT/CT images demonstrated a time-dependent uptake with a maximum of 2.7– 3.8% ID/cm3 in the tumors at approximately 24 h post-injection and mean tumor/muscle ratios in the range of 3.2–6.2 between 24 and 72 h post-injection. The kidneys and bladder were the predominant elimination organs. Gamma counting at 72 h postinjection showed 1.3–2.5% ID/g in the tumors and mean tumor/muscle ratios in the range of 4.9–9.4. Conclusion 111In-C4-DTPA bound rapidly to circulating albumin upon injection and showed time-dependent uptake in the tumors demonstrating a potential for clinical application as a companion imaging diagnostic for albumin-binding anticancer drugs.
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Proton Radiography and Fast Electron Propogation Through Cyliderically Compressed Targets
R. Jafer,L. Volpe,D. Batani,M. Koenig,S. Baton,E. Brambrink,F. Perez,K. Lancaster,M. Galimberti,R. Heathcote,M. Tolley,Ch. Spindloe,P. Koester,L. Labate,L. Gizzi,C. Benedetti,A. Sgattoni,M. Richetta,J 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.57 No.21
The paper describes the key points contained in the short term HiPER (High Power laser Energy Research) experimental road map, as well as the results of two phases of the experiment performed in “HiPER dedicated time slots. Experimental and theoretical results of relativistic electron transport in cylindrically compressed matter are presented. This experiment was achieved at the VULCAN laser facility (UK) by using four long pulse beams (∽4 × 50 J, 1 ns, at 0.53 µm) to compress a hollow plastic cylinder filled with plastic foam of three different densities (0.1, 0.3, and 1 g cm−3). In the first phase of the experiment, protons accelerated by a picosecond laser pulse were used to radiograph a cylinder filled with 0.1 g/cc foam. Point projection proton backlighting was used to measure the degree of compression as well as the stagnation time. Results were compared to those from hard X-ray radiography. Finally, Monte Carlo simulations of proton propagation in cold and compressed targets allowed a detailed comparison with 2D numerical hydro simulations. 2D simulations predict a density of 2-5 g cm−3 and a plasma temperature up to 100 eV at maximum compression. In the second phase of the experiment, a short pulse (10 ps, 160 J) beam generated fast electrons that propagated through the compressed matter by irradiating a nickel foil at an intensity of 5 × 1018 Wcm−2. X-ray spectrometer and imagers were implemented in order to estimate the compressed plasma conditions and to infer the hot electron characteristics. Results are discussed and compared with simulations.
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