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( Sung Won Lee ),( Dong Wook Choi ),( Sung Chul Park ),( Hee Jung Kim ),( Yang Hoon Nam ),( Dae Hee Choi ),( Chang Don Kang ),( Sung Joon Lee ),( Wan Joo Chun ),( Young Joon Ryu ) 대한장연구학회 2014 Intestinal Research Vol.12 No.3
Background/Aims: Ethanol administration causes intestinal epithelial cell damage by increasing intestinal permeability and the translocation of endotoxins from intestinal bacterial flora. Heat shock proteins (HSPs) are associated with recovery and protection from cell damage. The aim of the current study was to investigate differences in the expression of HSPs in the small intestine and the biochemical changes attributable to ethanol-induced intestinal damage. Methods: Ethanol (20%) was injected intraperitoneally (2.75 g/kg, 5.5 g/kg, 8.25 g/kg) in ICR mice and the same volume of saline was administered to controls. After 1 hour, the proximal, middle, and distal segments were taken from the small intestine and the degree of damage was analyzed. In each segment, the expression of HSPs was analyzed by western blotting. The expression of inflammatory mediators including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), and antioxidant enzyme such as glutathione-S-transferase were compared using real-time polymerase chain reaction assays. Results: In the control group, HSP70 increased in all segments of small intestine. Additionally, increases in the expression of HSP40 and HSP90 in the distal regions and an increase in HSP32 in the middle regions were observed. After ethanol treatment, greater histological damage was observed in the distal small intestine and significant decreases in HSPs were observed generally. Increased expression of IL-1β, TNF-α, and COX-2 was observed in small intestinal tissues exposed to ethanol-induced damage. However, there was no significant difference in the expression of an antioxidant enzyme. Conclusions: Significant differences in the expression of HSPs in different intestinal regions were observed. These differences may have been attributable to the distribution of intestinal bacteria. (Intest Res 2014;12:205-213)
Ryu, Sang-Wan,Park, Joonmo,Oh, Jin-Kyoung,Long, Dang Hoang,Kwon, Kwang-Woo,Kim, Young-Ho,Lee, Jun Key,Kim, Jin Hyeok WILEY-VCH Verlag 2009 Advanced functional materials Vol.19 No.10
<P>The improved performance of a bottom photonic crystal (PC) light-emitting diode (LED) is analyzed based on internal quantum efficiency (η<SUB>int</SUB>) and light-extraction efficiency (η<SUB>ex</SUB>). The bottom PC is fabricated by anodized aluminum oxide nanopatterns and InGaN quantum wells (QWs) are grown over it. Transmission electron microscopy images reveal that threading dislocations are blocked at the nanometer-sized air holes, resulting in improved optical emission efficiency of the QWs. From temperature-dependent photoluminescence measurements, the enhancement of η<SUB>int</SUB> is estimated to be 12%. Moreover, the enhancement of η<SUB>ex</SUB> is simulated to be 7% by the finite-difference time-domain method. The fabricated bottom PC LED shows a 23% higher optical power than a reference, which is close to the summation of enhancements in η<SUB>int</SUB> and η<SUB>ex</SUB>. Therefore, the bottom PC improves LED performance through higher optical quality of QWs as well as increased light extraction.</P> <B>Graphic Abstract</B> <P>A bottom photonic crystal (PC) is fabricated by anodized aluminum oxide nanopatterns to reduce threading dislocations in InGaN quantum wells grown over the PC (see image). The threading dislocations are blocked at the nanometer-sized air holes, resulting in a 23% improved optical power of the bottom PC LED compared to a reference. <img src='wiley_img/1616301X-2009-19-10-ADFM200801125-content.gif' alt='wiley_img/1616301X-2009-19-10-ADFM200801125-content'> </P>
Effect of Radial Extracorporeal Shock Wave Therapy on Hemiplegic Shoulder Pain Syndrome
Sung Hwan Kim,Kang Wook Ha,Yun Hee Kim,Pyong-Hwa Seol,Ho-Jun Kwak,Seung-Wan Park,Byung-Ju Ryu 대한재활의학회 2016 Annals of Rehabilitation Medicine Vol.40 No.3
Objective To investigate the effect of radial extracorporeal shock wave therapy (rESWT) on hemiplegic shoulder pain (HSP) syndrome.Methods In this monocentric, randomized, patient-assessor blinded, placebo-controlled trial, patients with HSP were randomly divided into the rESWT (n=17) and control (n=17) groups. Treatment was administered four times a week for 2 weeks. The visual analogue scale (VAS) score and Constant-Murley score (CS) were assessed before and after treatment, and at 2 and 4 weeks. The Modified Ashworth Scale and Fugl-Meyer Assessment scores and range of motion of the shoulder were also assessed.Results VAS scores improved post-intervention and at the 2-week and 4-week follow-up in the intervention group (p<0.05). Respective differences in VAS scores between baseline and post-intervention in the intervention and control groups were –1.69±1.90 and –0.45±0.79, respectively (p<0.05), between baseline and 2-week follow-up in the intervention and control groups were –1.60±1.74 and –0.34±0.70, respectively (p<0.05), and between baseline and 4-week follow-up in the intervention and control groups were –1.61±1.73 and –0.33±0.71, respectively (p<0.05). Baseline CS improved from 19.12±11.02 to 20.88±10.37 post-intervention and to 20.41±10.82 at the 2-week follow-up only in the intervention group (p<0.05).Conclusion rESWT consisting of eight sessions could be one of the effective and safe modalities for pain management in people with HSP. Further studies are needed to generalize and support these results in patients with HSP and a variety conditions, and to understand the mechanism of rESWT for treating HSP.
Ryu, Jinhyun,Ku, Bo Mi,Lee, Yeon Kyung,Jeong, Joo Yeon,Kang, Seokmin,Choi, Jungil,Yang, Yeongae,Lee, Dong Hoon,Roh, Gu Seob,Kim, Hyun Joon,Cho, Gyeong Jae,Choi, Wan Sung,Kim, Nayoung,Kang, Sang Soo Potamitis Press 2011 Anticancer research Vol.31 No.12
<P>High invasiveness of glioma cells is one of the reasons that patients with malignant glioma have a poor prognosis. Resveratrol, a plant compound abundant in the peel of grapes, has been suggested as a potential cancer chemopreventive agent. Therefore, we investigated the effect of resveratrol on glioma cell invasion.</P>