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RISS 인기검색어
- 검색키워드
- 저자 : Rout George Kerry (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Benefaction of probiotics for human health: A review
Kerry, Rout George,Patra, Jayanta Kumar,Gouda, Sushanto,Park, Yooheon,Shin, Han-Seung,Das, Gitishree 行政院衛生署藥物食品檢驗局 2018 JOURNAL OF FOOD AND DRUG ANALYSIS Vol.26 No.3
<P> Humans are a unique reservoir of heterogeneous and vivacious group of microbes, which together forms the human-microbiome superorganism. Human gut serves as a home to over 100-1000 microbial species, which primarily modulate the host internal environment and thereby, play a major role in host health. This spectacular symbiotic relationship has attracted extensive research in this field. More specifically, these organisms play key roles in defense function, eupepsia along with catabolism and anabolism, and impact brain-gut responses. The emergence of microbiota with resistance and tolerance to existing conventional drugs and antibiotics has decreased the drug efficacies. Furthermore, the modern biotechnology mediated nano-encapsulated multiplex supplements appear to be high cost and inconvenient. Henceforth, a simple, low-cost, receptive and intrinsic approach to achieve health benefits is vital in the present era. Supplementation with probiotics, prebiotics, and synbiotics has shown promising results against various enteric pathogens due to their unique ability to compete with pathogenic microbiota for adhesion sites, to alienate pathogens or to stimulate, modulate and regulate the host's immune response by initiating the activation of specific genes in and outside the host intestinal tract. Probiotics have also been shown to regulate fat storage and stimulate intestinal angiogenesis. Hence, this study aims to underline the possible beneficial impact of probiotics for human health and medical sectors and for better lifestyle. </P>
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MINIREVIEW] Cure of tuberculosis using nanotechnology: An overview
Rout George Kerry,Sushanto Gouda,Bikram Sil,다스기티스리,신한성,Gajanan Ghodake,Jayanta Kumar Patra 한국미생물학회 2018 The journal of microbiology Vol.56 No.5
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), a major health issue of the present era. The bacterium inhabits the host macrophage and other immune cells where it modulates the lysosome trafficking protein, hinders the formation of phagolysosome, and blocks the TNF receptor- dependent apoptosis of host macrophage/monocytes. Other limitations such as resistance to and low bioavailability and bio-distribution of conventional drugs aid to their high virulence and human mortality. This review highlights the use of nanotechnology-based approaches for drug formulation and delivery which could open new avenues to limit the pathogenicity of tuberculosis. Moreover phytochemicals, such as alkaloids, phenols, saponins, steroids, tannins, and terpenoids, extracted from terrestrial plants and mangroves seem promising against M. tuberculosis through different molecular mechanisms. Further understanding of the genomics and proteomics of this pathogenic microbe could also help overcome various research gaps in the path of developing a suitable therapy against tuberculosis.
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Current advances in nanocarriers for biomedical research and their applications
Rout, George Kerry,Shin, Han-Seung,Gouda, Sushanto,Sahoo, Sabuj,Das, Gitishree,Fraceto, Leonardo Fernandes,Patra, Jayanta Kumar Informa UK (TaylorFrancis) 2018 Artificial cells, nanomedicine, and biotechnology Vol.46 No.suppl2
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Revitalization of plant growth promoting rhizobacteria for sustainable development in agriculture
Gouda, Sushanto,Kerry, Rout George,Das, Gitishree,Paramithiotis, Spiros,Shin, Han-Seung,Patra, Jayanta Kumar Elsevier 2018 MICROBIOLOGICAL RESEARCH Vol.206 No.-
<P><B>Abstract</B></P> <P>The progression of life in all forms is not only dependent on agricultural and food security but also on the soil characteristics. The dynamic nature of soil is a direct manifestation of soil microbes, bio-mineralization, and synergistic co-evolution with plants. With the increase in world’s population the demand for agriculture yield has increased tremendously and thereby leading to large scale production of chemical fertilizers. Since the use of fertilizers and pesticides in the agricultural fields have caused degradation of soil quality and fertility, thus the expansion of agricultural land with fertile soil is near impossible, hence researchers and scientists have sifted their attention for a safer and productive means of agricultural practices. Plant growth promoting rhizobacteria (PGPR) has been functioning as a co-evolution between plants and microbes showing antagonistic and synergistic interactions with microorganisms and the soil. Microbial revitalization using plant growth promoters had been achieved through direct and indirect approaches like bio-fertilization, invigorating root growth, rhizoremediation, disease resistance etc. Although, there are a wide variety of PGPR and its allies, their role and usages for sustainable agriculture remains controversial and restricted. There is also variability in the performance of PGPR that may be due to various environmental factors that might affect their growth and proliferation in the plants. These gaps and limitations can be addressed through use of modern approaches and techniques such as nano-encapsulation and micro-encapsulation along with exploring multidisciplinary research that combines applications in biotechnology, nanotechnology, agro biotechnology, chemical engineering and material science and bringing together different ecological and functional biological approaches to provide new formulations and opportunities with immense potential.</P>
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