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Wu, Yiyan,Zhao, Zhenglin,Yang, Yupeng,Yang, Xudong,Jang, Eun Young,Schilaty, Nathan D,Hedges, David M,Kim, Sang Chan,Cho, Il Je,Zhao, Rongjie Chinese Medical Assn 2014 Chinese medical journal : CMJ Vol.127 No.10
<P>We previously demonstrated that the aqueous extract of the Schizandra chinensis fruit (AESC) ameliorated Cd-induced depletion of monoamine neurotransmitters in the brain through antioxidant activity. In the present study, we investigated the effect of AESC on anxiety-like behavior and the levels of norepinephrine and 3-methoxy-4-hydroxy-phenylglycol (a metabolite of norepinephrine) in different brain regions during ethanol withdrawal in rats.</P>
Knoevenagel Reaction of Pyropheophorbide and Synthesis of Its Heterocyclo-substituted Derivatives
Wang, Jinjun,Wu, Xuran,Han, Guangfan,Shen, Rongji 科學出版社 2005 CHINESE JOURNAL OF ORGANIC CHEMISTRY Vol.25 No.3
<P>Methyl pyropheophorbide-c? was used as starting material and the Knoevenagel reaction of the aldehyde group on pyropheophorbide with active methylene group in /?-diketone, a-cyanoketone or malono-nitrile was carried out to complete the synthesis of derivatives of methyl pyropheophorbide-a substituted with five-membered heterocycle at 3-positipon. The structures of all these new compounds were characterized by elemental analysis, UV, IR and LH NMR spectra.</P>
Bromination Reaction of Methyl Pyropheophorbide--a
Wang, Jinjun,Han, Guangfan,Wu, Xuran,Wang, Lumin,Shen, Rongji CHINESE MEDICAL ASSOCIATION 2004 CHINESE JOURNAL OF ORGANIC CHEMISTRY Vol.24 No.5
<P>Methyl pyropheophorbide-a (MPP-a) was used as starting material for the synthesis of new bromine-substituted chlorin compounds. The bromines were introduced into 3-position and meso-position of the chlorin chromophore by addition reaction and substitution reaction with the bromide reagents to give mono-bromine- and tri-bromine-substituted chlorines. The formal addition product, hydrolyzate and esterified product were obtained by addition reaction with 30% hydrogen bromide in acetic acid. MPP-a was oxidized with OsO<SUB>4</SUB> in THF containing catalytic pyridine at 0 ℃, and followed by glycol cleavage with sodium periodate in aqueous THF to give the methyl pyropheophorbide- d (MPP-d) which was reacted with carbon tetrabromide and triphenylphosphine to generate gem-dibromine substituted product at 3~b-position. The structures of all new compounds were characterized by elemental analysis, UV, IR and ]H NMR spectra.</P>
Wang, Jinjun,Han, Guangfan,Wu, Xuran,Shen, Rongji CHINESE MEDICAL ASSOCIATION 2005 CHINESE JOURNAL OF ORGANIC CHEMISTRY Vol.25 No.1
<P>The chlorophyll-a (1) was converted into the chlorins 2b<SUP>4</SUP>b by air-oxidation in acid or basic condition. The methyl pheophorbide-a (5) was obtained from chlorophyll-a by transesterification and de-metallation. The addition to double bond at 3-position of 5 with hydrochloric acid yielded alcohol chlorin 6 which was oxidized purpure-18 derivative (7) by air-oxidation in basic condition. The methyl pheophor-bide-a (5) was oxidized with osmium oxide and sodium periodate to give chlorin 8 which was converted into aldehyde purpure-18 (9) and purpure-7 trimethyl ester (10) by air-oxidation in butanol in the presence of so-dium. The purpure-18 ester (3), prepared also from the pheophorbide-a (4) in the same reaction condition like the chlorophyll-a (1), reacted with 2-methylbutylamine to give AH2-methylbutyl)-purpure-18 imide (lla) and 12-formyl-purpure-18 imide (lib). The structures of all chlorophyll derivatives were characterized by UV, IR, JH NMR spectra and elemental analysis. The possible mechanisms in accordance with the corre-sponding chemical reaction and reaction condition were tentatively proposed.</P>
Zhao, ZhengLin,Kim, Sang Chan,Wu, YiYan,Zhang, Jie,Xu, YanJi,Cho, Il Je,Yang, Chae Ha,Lee, Bong Hyo,Zhao, RongJie Elsevier 2014 Neuroscience Letters Vol.567 No.-
The role of neuropeptide Y (NPY) in the central nucleus of amygdala (CeA) in the preventive effects of acupuncture against ethanol withdrawal-induced anxiety was investigated. Rats were treated with 3 g/kg/day of ethanol for 28 days, followed by 3 days of withdrawal. Bilateral acupuncture treatment at HT7 (Shen-Men), PC6 (Nei-Guan) or a non-acupoint was respectively added to the rats during the withdrawal once a day for three days. Enzyme-linked immunosorbent assays and real-time polymerase chain reaction analyses showed there was a significant decrease in NPY protein and mRNA expression in the CeA during ethanol withdrawal, which was reversed by acupuncture at HT7 but neither at PC6 nor at a non-acupoint. Acupuncture at HT7 also greatly inhibited the decrease in cAMP response element-binding protein (CREB) phosphorylation in the CeA. In elevated plus maze tests, a selective NPY Y1 receptor antagonist BIBP 3226 into the CeA before the acupuncture abolished almost completely the anxiolytic effect of acupuncture at HT7. These results suggest that acupuncture at HT7 rescues the depletion of amygdaloid NPY and reverses the decrease in CREB phosphorylation to produce anxiolytic effects during ethanol withdrawal. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats
Zhao, ZhengLin,Kim, Young Woo,Wu, YiYan,Zhang, Jie,Lee, Ju-Hee,Li, XiaoHua,Cho, Il Je,Park, Sang Mi,Jung, Dae Hwa,Yang, Chae Ha,Kim, Sang Chan,Zhao, RongJie The Korean Society of Ginseng 2014 Journal of Ginseng Research Vol.38 No.4
Background: Korean Red Ginseng (KRG) is known to have antianxiety properties. This study was conducted to investigate the anxiolytic effects of KRG extract (KRGE) during ethanol withdrawal (EW) and the involvement of the mesoamygdaloid dopamine (DA) system in it. Methods: Rats were treated with 3 g/kg/d of ethanol for 28 d, and subjected to 3 d of withdrawal. During EW, KRGE (20 mg/kg/d or 60 mg/kg/d, p.o.) was given to rats once/d for 3 d. Thirty min after the final dose of KRGE, anxiety-like behavior was evaluated in an elevated plus maze (EPM), and plasma corticosterone (CORT) levels were determined by a radioimmunoassay (RIA). In addition, concentrations of DA and 3,4-dihydroxyphenylacetic acid (DOPAC) in the central nucleus of the amygdala (CeA) were also measured by high performance liquid chromatography (HPLC). Results: The EPM test and RIA revealed KRGE inhibited anxiety-like behavior and the over secretion of plasma CORT during EW. Furthermore, the behavioral effect was blocked by a selective DA D2 receptor (D2R) antagonist (eticlopride) but not by a selective DA D1 receptor (D1R) antagonist (SCH23390). HPLC analyses showed KRGE reversed EW-induced decreases of DA and DOPAC in a dose-dependent way. Additionally, Western blotting and real-time polymerase chain reaction (PCR) assays showed that KRGE prevented the EW-induced reductions in tyrosine hydroxylase (TH) protein expression in the CeA and TH mRNA expression in the ventral tegmental area (VTA). Conclusion: These results suggest that KRGE has anxiolytic effects during EW by improving the mesoamygdaloid DA system.
Haiyang Yu,Shangbin Yang,Haotao Li,Rongjie Wu,Biqin Lai,Qiujian Zheng 대한척추신경외과학회 2023 Neurospine Vol.20 No.1
After spinal cord injury (SCI), endogenous neural stem cells are activated and migrate to the injury site where they differentiate into astrocytes, but they rarely differentiate into neurons. It is difficult for brain-derived information to be transmitted through the injury site after SCI because of the lack of neurons that can relay neural information through the injury site, and the functional recovery of adult mammals is difficult to achieve. The development of bioactive materials, tissue engineering, stem cell therapy, and physiotherapy has provided new strategies for the treatment of SCI and shown broad application prospects, such as promoting endogenous neurogenesis after SCI. In this review, we focus on novel approaches including tissue engineering, stem cell technology, and physiotherapy to promote endogenous neurogenesis and their therapeutic effects on SCI. Moreover, we explore the mechanisms and challenges of endogenous neurogenesis for the repair of SCI.
Gu, Changhong,Zhao, ZhengLin,Zhu, Xiaodong,Wu, Tong,Lee, Bong Hyo,Jiao, Yu,Lee, Chul Won,Jung, Dae Hwa,Yang, Chae Ha,Zhao, Rongjie,Kim, Sang Chan Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>Anxiety during nicotine withdrawal (NicW) is a key risk factor for smoking relapse. Semen<I> Ziziphi Spinosae</I> (SZS), which is a prototypical hypnotic-sedative herb in Oriental medicine, has been clinically used to treat insomnia and general anxiety disorders for thousands of years. Thus, the present study evaluated the effects of the aqueous extract of SZS (AESZS) on NicW-induced anxiety in male rats that received subcutaneous administrations of nicotine (Nic) (0.4 mg/kg, twice a day) for 7 d followed by 4 d of withdrawal. During NicW, the rats received four intragastric treatments of AESZS (60 mg/kg/d or 180 mg/kg/d). AESZS dose-dependently attenuated NicW-induced anxiety-like behaviors in the elevated plus maze (EPM) tests and 180 mg/kg/d AESZS inhibited NicW-induced increases in plasma corticosterone. Additionally, the protein and mRNA expressions of corticotropin-releasing factor (CRF) and CRF type 1 receptor (CRF1R) increased in the central nucleus of the amygdala (CeA) during NicW, but these changes were suppressed by 180 mg/kg/d AESZS. A post-AESZS infusion of CRF into the CeA abolished the attenuation of anxiety by AESZS and 180 mg/kg/d AESZS suppressed NicW-induced increases in norepinephrine and 3-methoxy-4-hydroxy-phenylglycol levels in the CeA. The present results suggest that AESZS ameliorated NicW-induced anxiety via improvements in CRF/CRF1R and noradrenergic signaling in the CeA.</P>
Zhao, ZhengLin,Kim, Sang Chan,Liu, HongFeng,Zhang, Jie,Wang, YuHua,Cho, Il Je,Lee, Bong Hyo,Song, Chang Hyun,Lee, Chul Won,Yang, Chae Ha,Zhao, RongJie,Wu, YiYan Hindawi 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-
<P>Acupuncture improves ethanol withdrawal-induced anxiety in rats in an acupoint-dependent manner. Thus, the present study investigated the effects of acupuncture on acute restraint stress- (ARS-) induced anxiety. Male rats were exposed to ARS for 3 h followed by acupuncture at either PC6 (Neiguan), HT7 (Shenmen), or a nonacupoint (tail) once a day for three consecutive days. Five minutes after the third acupuncture treatment, anxiety-like behavior was evaluated in an elevated plus maze (EPM). Additionally, plasma corticosterone (CORT) levels were measured by radioimmunoassay and the concentrations of norepinephrine (NE) and 3-methoxy-4-hydroxy-phenylglycol (MHPG) in the central nucleus of the amygdala (CeA) were determined using high-performance liquid chromatography. Acupuncture at PC6, but not HT7 or a nonacupoint, attenuated anxiety-like behavior, but this attenuation was abolished by a postacupunctural intra-CeA infusion of NE. Acupuncture at PC6 also reduced the oversecretion of plasma CORT and inhibited increases in amygdaloid NE and MHPG induced by ARS. Further, Western blot analyses and real-time polymerase chain reaction assays revealed that acupuncture at PC6 prevented ARS-induced enhancements in the protein and mRNA expressions of tyrosine hydroxylase in the CeA. These results suggest that acupuncture performed specifically at acupoint PC6 reduces ARS-induced anxiety-like behavior by dampening amygdaloid noradrenergic responses.</P>