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Poly-ε-Caprolactone/Propolis Electrospun Yarns as Suture
Rezvan Mohamadinooripoor,Soheila Kashanian,Kobra Omidfar 한국섬유공학회 2023 Fibers and polymers Vol.24 No.8
Electrospinning is a well-known promising technique for the cost-effective and rapid fabrication of therapeutic-loaded nanofibers. Electrospun fibers have many merits that give them prospects in the production of therapeutic-loaded sutures. Despite the desirable properties of electrospun fibrous yarns, they have no prospective mechanical properties as a suture. Hence, improving the mechanical properties of the electrospun yarns is an open issue. This work applied electrospun composite mats consisting of poly-ε-caprolactone (PCL)/propolis ethanolic extract (PEE) with random and aligned morphological features of fibers to fabricate yarns. The PCL-PEE yarns were fabricated by twisting a ribbon-like part of these mats. Then, these yarns were characterized and evaluated as sutures. In vitro yarn release was followed during 221 h. Tensile testing of yarns was also studied. In addition, in vitro cell culture studies for the biocompatibility of MG-63 and human dermal fibroblast cells on the sutures and also antifungal and antibacterial effects of the sutures were assessed. These sutures were used for suturing an induced-wound rat model to follow in vivo effectiveness. Histopathological investigations were also done. Consequently, a PEE-PCL suture with elastomeric, mechanical, antibacterial, and antifungal properties and accelerated wound-healing features provides a proper and promising suture.
An Overview on Wound Dressings and Sutures Fabricated by Electrospinning
Rezvan Mohamadinooripoor,Soheila Kashanian,Elham Arkan 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.1
Electrospinning is simple and cost-effective technique for micro/nano-fibers production that have emerged recently. Electrospun fibers have a wide variety of applications. They can provide ideal wound dressings, and so exhibit significant potential in production of therapeutic loaded sutures. Wound treatments have a huge commercial enterprise and the demand of them are increasing day by day. Thus, it seems essential to summarize wound dressings and sutures which were prepared using electrospinning technique. In this review, we will investigate the wound healing processes and the process of electrospinning and also the effective parameters of the process. Future directions of this compilation will explore kinds of electrospun wound dressing and sutures.