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      저자 : Renata R. Urban (검색결과 1 건)
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        Bevacizumab toxicity in heavily pretreated recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancers

        Jovana Y. Martin,Renata R. Urban,John B. Liao,Barbara A. Goff 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.5

        Objective: Bevacizumab was recently approved by the US Food and Drug Administration foruse in recurrent platinum resistant epithelial ovarian cancer (EOC), fallopian tube cancer(FTC), or primary peritoneal cancer (PPC) when no more than two prior cytotoxic regimenshave been used; due to concerns for gastrointestinal perforation. We sought to determinebevacizumab-related toxicities in heavily pretreated recurrent EOC. Methods: We performed a retrospective chart review of patients with recurrent EOC, FTC,and PPC from 2001 to 2011. Patients who received at least two prior chemotherapy regimensbefore bevacizumab were included. Medical records were reviewed for bevacizumabassociated toxicities. The Wilcoxon-Mann-Whitney test was used to compare quantitativevariables. Survival was estimated with the Kaplan-Meier method. Results: Sixty patients met inclusion criteria. At the start of bevacizumab treatment, themedian age was 60 years and the median body mass index was 26.5 kg/m2. More than 50%of patients received bevacizumab after three prior cytotoxic regimens. Grade 3 or higherbevacizumab associated toxicity events occurred in four patients, including one patient whodeveloped a rectovaginal fistula. The median overall survival from the start of bevacizumabtreatment was 21.05 months (95% CI, 18.23 to 32.67; range, 1.9 to 110 months). The numberof cytotoxic regimens prior to bevacizumab treatment did not differ in those that experienceda toxicity versus those that did not (p=0.66). Conclusion: The use of bevacizumab in heavily pretreated EOC, FTC, or PPC is worthconsideration.

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