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Qian Yexiong,Ren Qiaoyu,Jiang Lingyu,Zhang Jing,Chen Changle,Chen Liang 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.3
Methyl-CpG-binding domain (MBD) proteins in plants are important trans-acting factors specifically recognizing methylated DNA. The MBD proteins can compact chromatins to repress transcription by recruiting chromatin-modifying complexes that contain histone deacetylase activities and chromatin remodeling factors, and play a crucial biological role in the growth and development in plants. Currently, very little is known regarding the structure and function of MBD genes in plants. In this study, we performed a genome-wide identification and expression profile analysis of maize MBD genes (ZmMBDs) from the latest version of the maize (B73) genome. By analyzing phylogenetic relationship of MBD gene families from Arabidopsis, rice, wheat, and maize, all 14 MBD proteins in maize were categorized into four subclasses. Furthermore, chromosome location and schematic structure revealed an unevenly distribution on chromosomes and structure features of MBD genes in maize, respectively. Eventually, EST expression data mining, microarray data clustering analysis, and semi-quantitative and quantitative expression profile analyses detected in seedling leaves and stems by heat, drought, and salt-stress treatments have demonstrated that these genes had temporal and spatial expression pattern and exhibited different expression levels under heat, drought, and salt-stress conditions, suggesting that functional diversification of the MBD gene family in maize. In addition, through electrophoretic mobility shift assay (EMSA) a representative MBD protein, ZmMBD11, exhibited in vitro DNA-binding activity, indicating that that the MBD proteins in maize might play a role in reading cytosine methylation. Taken together, these results would provide an important theoretical basis for future functional verification of ZmMBD genes and also facilitate future experimental research to further unravel the mechanisms of epigenetic regulation in plants.
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Surgical management of inflammatory bowel disease in China: a systematic review of two decades
( Qiao Yu ),( Ren Mao ),( Lei Lian ),( Siew Chien Ng ),( Shenghong Zhang ),( Zhihui Chen ),( Yanyan Zhang ),( Yun Qiu ),( Baili Chen ),( Yao He ),( Zhirong Zeng ),( Shomron Ben-horin ),( Xinming Song 대한장연구학회 2016 Intestinal Research Vol.14 No.4
Background/Aims: The past decades have seen increasing incidence and prevalence of inflammatory bowel disease (IBD) in China. This article aimed to summarize the current status and characteristics of surgical management for IBD in China. Methods: We searched PubMed, Embase, and Chinese databases from January 1, 1990 to July 1, 2014 for all relevant studies on the surgical treatment IBD in China. Eligible studies with sufficient defined variables were further reviewed for primary and secondary outcome measures. Results: A total of 74 studies comprising 2,007 subjects with Crohn`s disease (CD) and 1,085 subjects with ulcerative colitis (UC) were included. The percentage of CD patients misdiagnosed before surgery, including misdiagnosis as appendicitis or UC, was 50.8%±30.9% (578/1,268). The overall postoperative complication rate was 22.3%±13.0% (267/1,501). For studies of UC, the overall postoperative complication rate was 22.2%±27.9% (176/725). In large research centers (n>50 surgical cases), the rates of emergency operations for CD (P =0.032) and in-hospital mortalities resulting from both CD and UC were much lower than those in smaller research centers (n≤50 surgical cases) (P =0.026 and P <0.001, respectively). Regarding the changes in CD and UC surgery over time, postoperative complications (P =0.045 for CD; P =0.020 for UC) and postoperative in-hospital mortality (P =0.0002 for CD; P =0.0160 for UC) both significantly improved after the year 2010. Conclusions: The surgical management of IBD in China has improved over time. However, the rates of misdiagnosis and postoperative complications over the past two decades have remained high. Large research centers were found to have relatively better capacity for surgical management than the smaller ones. Higher quality prospective studies are needed in China. (Intest Res 2016;14:322-332)
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