Environmental Illness : A Controlled Study of SubJects With '20th Century Disease'

Black, Donald W.,Rathe, Ann,Goldstein, Rise B. MediMedia Korea 1991 JAMA-Korea Vol.6 No.3

A Stable Organic Radical Delocalized on a Highly Twisted π System Formed Upon Palladium Metalation of a Möbius Aromatic Hexaphyrin

Rath, Harapriya,Tokuji, Sumito,Aratani, Naoki,Furukawa, Ko,Lim, Jong Min,Kim, Dongho,Shinokubo, Hiroshi,Osuka, Atsuhiro WILEY-VCH Verlag 2010 Angewandte Chemie Vol.122 No.8

<B>Graphic Abstract</B> <P>Ein neuer Dreh bei Porphyrinen: Die Metallierung von Möbius-aromatischem Hexakis(pentafluorphenyl)[28]hexaphyrin ergibt ein stabiles organisches Radikal, das über ein zweifach verdrehtes π-System delokalisiert ist. Der Zweiphotonenabsorptionsquerschnitt ist deutlich höher als bei nichtaromatischen expandierten Porphyrinen (Pd rosa, Cl grün, N blau; ohne Phenylringe). <img src='wiley_img/00448249-2010-122-8-ANGE200906017-content.gif' alt='wiley_img/00448249-2010-122-8-ANGE200906017-content'> </P>

Impact of Quantitative Feeding on Nutritional Parameters of Fifth Instar Larvae of Antheraea mylitta

Rath, Sudhansu Sekhar Korean Society of Sericultural Science 2010 International Journal of Industrial Entomology Vol.20 No.2

Feeding is an important aspect of insect nutrition which in turn supports growth, development, reproduction and survival. The impact of quantitative feeding on nutritional parameters of fifth instar Antheraea mylitta larvae was studied by providing fresh leaves of Terminalia tomentosa for 1 to 4 times a day. All the parameters improved upon providing fresh diets more times over the single diet (1FD). The absolute body weight increased with increase in number of feeds/day significantly (P<0.001). While the maximum weight recorded was 29.61 g in 1FD, the respective weights for two feeds/day (2FD), three feeds/day (3FD) and four feeds/day (4FD) were 39.41 g, 40.63 g and 42.66 g respectively. Feeding period and instar duration were declined (P<0.001) and survival increased significantly (P<0.001) upon increase in the number of diets. Nutritional indices like ingestion, digestion, relative consumption rate (RCR), relative growth rate (RGR) and gain in body weight increased significantly with the increase in number of feeds/day, but approximate digestibility (AD) and efficiency of conversion of ingested food (ECI) declined, while efficiency of conversion of digested food (ECD) did not change.

In Silico Study of miRNA Based Gene Regulation, Involved in Solid Cancer, by the Assistance of Argonaute Protein

Rath, Surya Narayan,Das, Debasrita,Konkimalla, V Badireenath,Pradhan, Sukanta Kumar Korea Genome Organization 2016 Genomics & informatics Vol.14 No.3

Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs (miRNAs). Argonaute (AGO) protein is a family of protein which assists in miRNAs to bind with mRNAs of the target genes. Hence, study of the binding mechanism between AGO protein and miRNAs, and also with miRNAs-mRNAs duplex is crucial for understanding the RNA silencing mechanism. In the current work, 64 genes and 23 miRNAs have been selected from literatures, whose deregulation is well established in seven types of solid cancer like lung, breast, prostate, pancreases, colorectal, stomach, and bladder cancer. In silico study reveals, miRNAs namely, miR-106a, miR-21, and miR-29b-2 have a strong binding affinity towards PTEN, TGFBR2, and VEGFA genes, respectively, suggested as important factors in RNA silencing mechanism. Furthermore, interaction between AGO protein (PDB ID-3F73, chain A) with selected miRNAs and with miRNAs-mRNAs duplex were studied computationally to understand their binding at molecular level. The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding miRNAs based gene silencing mechanism in solid cancer.

In silico discovery and evaluation of phytochemicals binding mechanism against human catechol-O-methyltransferase as a putative bioenhancer of L-DOPA therapy in Parkinson disease

Rath, Surya Narayan,Jena, Lingaraja,Bhuyan, Rajabrata,Mahanandia, Nimai Charan,Patri, Manorama Korea Genome Organization 2021 Genomics & informatics Vol.19 No.1

Levodopa (L-DOPA) therapy is normally practised to treat motor pattern associated with Parkinson disease (PD). Additionally, several inhibitory drugs such as Entacapone and Opicapone are also cosupplemented to protect peripheral inactivation of exogenous L-DOPA (~80%) that occurs due to metabolic activity of the enzyme catechol-O-methyltransferase (COMT). Although, both Entacapone and Opicapone have U.S. Food and Drug Administration approval but regular use of these drugs is associated with high risk of side effects. Thus, authors have focused on in silico discovery of phytochemicals and evaluation of their effectiveness against human soluble COMT using virtual screening, molecular docking, drug-like property prediction, generation of pharmacophoric property, and molecular dynamics simulation. Overall, study proposed, nine phytochemicals (withaphysalin D, withaphysalin N, withaferin A, withacnistin, withaphysalin C, withaphysalin O, withanolide B, withasomnine, and withaphysalin F) of plant Withania somnifera have strong binding efficiency against human COMT in comparison to both of the drugs i.e., Opicapone and Entacapone, thus may be used as putative bioenhancer in L-DOPA therapy. The present study needs further experimental validation to be used as an adjuvant in PD treatment.

Effect of Quantitative Nutrition on Adult Characters and Reproductive Fitness in Tropical Tasar Silkworm Antheraea mylitta

Rath S. S. Korean Society of Sericultural Science 2005 International Journal of Industrial Entomology Vol.10 No.1

Nutrition is very essential for growth, development and reproduction. The quantitative impetus of nutritional factor on adult characters and reproductive fitness was studied in Antheraea mylitta by providing fresh leaves of Terminalia tomentosa for 1 to 4 times a day to $5^{th}$ instar larvae. All the characters have improved on giving fresh diet more times over the single diet. The adult weight has strong effect on the reproductive potential i.e., female pupa and moth weight, survivability, pupation rate, emergence percentage, fecundity, fertility, egg weight and hatched out larval weight. The improvement recorded to the tune of $70\%,\;77.1\%,\;115.4\%,\;36.7\%,\;45.9\%\;and\;218.3\%$ in larval weight gain, survivability, pupation rate, female pupa weight, moth weight and fecundity respectively when fresh diets were provided 4 times a day against single diet. The adult emergence percentage has increased from $66.4\%\;to\;96.2\%$ and fertility rose from $52.2\%\;to\;93.6\%$. The weight of eggs and the larvae hatched out of it also found to be significantly higher in 4 diets a day condition. The study revealed that optimization of fresh diet frequency should be maintained to obtain higher egg production and fertility in order to get vigorous larvae to continue the generation.

Effects of manganese substitution at the B-site of lanthanum-rich strontium titanate anodes on fuel cell performance and catalytic activity

Rath, Manas K.,Ahn, Byung-Guk,Choi, Byung-Hyun,Ji, Mi-Jung,Lee, Ki-Tae Elsevier 2013 Ceramics international Vol.39 No.6

<P><B>Abstract</B></P> <P>Sr<SUB>0.4</SUB>La<SUB>0.6</SUB>Ti<SUB>1−<I>x</I> </SUB>Mn<SUB> <I>x</I> </SUB>O<SUB>3−<I>δ</I> </SUB> with rhombohedral structure has been investigated in terms of their electrochemical performance, redox stability, and electro-catalytic properties for solid oxide fuel cell anodes. The performance of Sr<SUB>0.4</SUB>La<SUB>0.6</SUB>Ti<SUB>1−<I>x</I> </SUB>Mn<SUB> <I>x</I> </SUB>O<SUB>3−<I>δ</I> </SUB> anodes for solid oxide fuel cells strongly depends on the Mn substitution at the B-site of the perovskites. Electrical conductivity of Sr<SUB>0.4</SUB>La<SUB>0.6</SUB>Ti<SUB>1−<I>x</I> </SUB>Mn<SUB> <I>x</I> </SUB>O<SUB>3−<I>δ</I> </SUB> increases with increasing Mn content. X-ray photoelectron spectroscopy analysis reveals that the amount of Mn<SUP>3+</SUP> and Ti<SUP>3+</SUP>, which is an electronic charge carrier, increases with Mn doping. The reduced anode powders with high Mn/Ti ratio show oxygen storage capability and a low carbon deposition rate. Linear thermal expansion coefficients of Sr<SUB>0.4</SUB>La<SUB>0.6</SUB>Ti<SUB>1−<I>x</I> </SUB>Mn<SUB> <I>x</I> </SUB>O<SUB>3−<I>δ</I> </SUB> anodes range from 9.46×10<SUP>−6</SUP> K<SUP>−1</SUP> to 11.3×10<SUP>−6</SUP> K<SUP>−1</SUP>. The maximum power densities of the single cell with the Sr<SUB>0.4</SUB>La<SUB>0.6</SUB>Ti<SUB>0.2</SUB>Mn<SUB>0.8</SUB>O<SUB>3−<I>δ</I> </SUB> anode in humidified H<SUB>2</SUB> and CH<SUB>4</SUB> at 800°C are 0.29Wcm<SUP>−2</SUP> and 0.24Wcm<SUP>−2</SUP>, respectively.</P>

Higher-order sliding mode observer for estimation of tyre friction in ground vehicles

Rath, Jagat Jyoti,Veluvolu, Kalyana Chakravarthy,Defoort, Michael,Yeng Chai Soh IET 2014 IET control theory & applications Vol.8 No.6

<P>The estimation of friction coefficient for a vehicle when it traverses on different surfaces has been an important issue. In this work, the longitudinal vehicle dynamics, the torsional tyre dynamics and the non-linear LuGre friction dynamics are integrated to model the quarter vehicle dynamics. The road adhesion coefficient in the vehicle dynamics is unknown and varies with the contact surface. To address this issue, the authors consider a class of non-linear uncertain systems that covers the vehicle dynamics and develop a higher-order sliding mode observer based on supertwisting algorithm for state and unknown input estimations. Under Lipschitz conditions for the non-linear functions, the convergence of the estimation error is established. By estimating the road adhesion coefficient, the coefficient of friction can be estimated. Simulation results demonstrate the effectiveness of the proposed observer for state and unknown input estimation.</P>

Simultaneous Estimation of Road Profile and Tire Road Friction for Automotive Vehicle

Rath, J. J.,Veluvolu, K. C.,Defoort, M. IEEE 2015 IEEE Transactions on Vehicular Technology VT Vol.64 No.10

<P>The longitudinal motion control of automotive vehicles is heavily reliant on information about the time-varying tire road friction coefficient. In the presence of varying road roughness profiles, the effective vertical load on each wheel varies dynamically, influencing the tire friction. In this paper, we integrated the vertical and longitudinal dynamics of a quarter wheel to form an integrated nonlinear model. In the modeled dynamics, the time-varying random road profile and the tire friction are treated as unknown inputs. To estimate these unknown inputs and states simultaneously, a combination of nonlinear Lipschitz observer and modified super-twisting algorithm (STA) observer is developed. Under Lipschitz conditions for the nonlinear functions, the convergence of the estimation error is established. Simulation results performed with the high-fidelity vehicle simulation software CarSim demonstrate the effectiveness of the proposed scheme in the estimation of states and unknown inputs.</P>

Male Mating History in Antheraea mylitta and its Effect on Ejaculation Size and Female Reproductive Fitness

Rath, Sudhansu Sekhar Korean Society of Sericultural Science 2011 International Journal of Industrial Entomology Vol.22 No.2

Reproductive activity in the economically important insect, Antheraea mylitta is very important because the female reproduces only once in her life time and the aging is very rapid and costly. It is a capital breeder and strictly a monoandrous species. To know how strategically the insect behaves and the male allocates its ejaculate resource more prudently during its successive mating with virgin females to maximize its own fitness and the fitness of the female with whom it mated, both being most important to sericulture industry. So, the present study was undertaken and the results revealed fresh and virgin females always prefer to mate with fresh virgin males (84%) and receives high dose of ejaculates leading to higher hatchability than to virgin males of one day old (13.7%) and one day old males with mating experience (2.3%). The ejaculation size (as referred to eupyrene sperm count in the ejaculation) declined significantly over successive mating (r = -0.9931, P < 0.001), so also the male body weight (r = -0.9560, P < 0.001). The quantity of ejaculate passed to female also dramatically declined during aging (r = -0.9982, P < 0.001). It was found that male weight contribute substantially to the quantum of ejaculate (r = -0.9519, P < 0.001), so also higher fecund females receive relatively more ejaculate than the lower group to reach higher reproductive fitness. The life time fecundity was found to be $334{\pm}31$.