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Michael Strupp,Katharina Feil,Stanislavs Bardins,Raphaela Waidelich 대한배뇨장애요실금학회 2014 International Neurourology Journal Vol.18 No.4
Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they arewidely used to treat different neurological disorders. Here we present a patient with idiopathic downbeat nystagmus and lowerurinary tract symptoms (LUTS) due to benign prostatic hyperplasia who was treated with the sustained-release form of4-aminopyridine (4-AP). During treatment with 4-AP, the LUTS improved. This improvement was monitored by using uroflowmetryand the International Prostate Symptom Score. A significant improvement of symptoms was observed in relationto the voided volume. This included an improved emptying of the bladder without an increase in residual urine. In animalstudies, both nonselective K+ channel blockade and selective voltage-sensitive potassium blockade by 4-AP resulted in increasedcontraction on rat detrusor strips. To our knowledge, this is the first clinical observation of the mode of action of 4-APin urological symptoms in humans.