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- 저자 : R. Senthil Murugan (검색결과 1 건)
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S. Nagini,P. Manikandan,R. Senthil Murugan,H. Abbas,S.K. Abraham 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.3
The present study was designed to evaluate the protective effects of ethanolic Ocimum sanctumleaf extractagainst 7,12-dimethylbenz[a]anthracene (DMBA)-induced genotoxicity, oxidative stress, and imbalance in xenobiotic-metab-olizing enzymes. Four different concentrations of ethanolic O. sanctumleaf extract (100, 200, 300, and 400 mg/kg of bodyweight) were administered to Wistar rats by intragastric intubation for five consecutive days followed by intraperitoneal in-jection of DMBA (35 mg/kg of body weight) 90 minutes after the final dose of the extract. Administration of DMBA in-creased bone marrow micronuclei, phase I enzymes, lipid peroxidation, and protein carbonyl formation. This was accompa-nied by a significant decrease in the activities of phase II detoxification enzymes and antioxidants in the liver, erythrocytes,and bone marrow. Pretreatment with ethanolic O. sanctumleaf extract at a concentration of 300 mg/kg of body weight sig-nificantly reduced micronuclei formation and phase I enzymes as well as lipid and protein oxidation with enhanced antioxi-dant and phase II enzyme activities. The results of the present study suggest that ethanolic O. sanctumleaf extract inhibitsDMBA-induced genotoxicity and oxidative stress by modulating xenobiotic-metabolizing enzymes, reducing the extent oflipid and protein oxidation and up-regulating antioxidant defenses.
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