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<i>Nardostachys jatamansi</i> Ethanol Extract Ameliorates Aβ42 Cytotoxicity
Liu, Quan Feng,Jeon, Youngjae,Sung, Yung-wei,Lee, Jang Ho,Jeong, Haemin,Kim, Young-Mi,Yun, Hye Sup,Chin, Young-Won,Jeon, Songhee,Cho, Kyoung Sang,Koo, Byung-Soo Pharmaceutical Society of Japan 2018 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.41 No.4
AN IDENTITY ON THE 2m-TH POWER MEAN VALUE OF THE GENERALIZED GAUSS SUMS
Feng Liu,Quan-Hui Yang 대한수학회 2012 대한수학회보 Vol.49 No.6
In this paper, using analytic method and the properties of the Legendre's symbol, we prove an exact calculating formula on the $2m$-th power mean value of the generalized quadratic Gauss sums for $m{\geq}2$. This solves a conjecture of He and Zhang [On the 2k-th power mean value of the generalized quadratic Gauss sums, Bull. Korean Math. Soc. 48 (2011), no. 1, 9-15].
Liu, Chun-Ying,Zhou, Rui-Xin,Sun, Chang-Kai,Jin, Ying-Hua,Yu, Hong-Shan,Zhang, Tian-Yang,Xu, Long-Quan,Jin, Feng-Xie The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.3
Background: Minor ginsenosides, those having low content in ginseng, have higher pharmacological activities. To obtain minor ginsenosides, the biotransformation of American ginseng protopanaxadiol (PPD)-ginsenoside was studied using special ginsenosidase type-I from Aspergillus niger g.848. Methods: DEAE (diethylaminoethyl)-cellulose and polyacrylamide gel electrophoresis were used in enzyme purification, thin-layer chromatography and high performance liquid chromatography (HPLC) were used in enzyme hydrolysis and kinetics; crude enzyme was used in minor ginsenoside preparation from PPD-ginsenoside; the products were separated with silica-gel-column, and recognized by HPLC and NMR (Nuclear Magnetic Resonance). Results: The enzyme molecular weight was 75 kDa; the enzyme firstly hydrolyzed the C-20 position 20-O-${\beta}$-D-Glc of ginsenoside Rb1, then the C-3 position 3-O-${\beta}$-D-Glc with the pathway $Rb1{\rightarrow}Rd{\rightarrow}F2{\rightarrow}C-K$. However, the enzyme firstly hydrolyzed C-3 position 3-O-${\beta}$-D-Glc of ginsenoside Rb2 and Rc, finally hydrolyzed 20-O-L-Ara with the pathway $Rb2{\rightarrow}C-O{\rightarrow}C-Y{\rightarrow}C-K$, and $Rc{\rightarrow}C-Mc1{\rightarrow}C-Mc{\rightarrow}C-K$. According to enzyme kinetics, $K_m$ and $V_{max}$ of Michaelis-Menten equation, the enzyme reaction velocities on ginsenosides were Rb1 > Rb2 > Rc > Rd. However, the pure enzyme yield was only 3.1%, so crude enzyme was used for minor ginsenoside preparation. When the crude enzyme was reacted in 3% American ginseng PPD-ginsenoside (containing Rb1, Rb2, Rc, and Rd) at $45^{\circ}C$ and pH 5.0 for 18 h, the main products were minor ginsenosides C-Mc, C-Y, F2, and C-K; average molar yields were 43.7% for C-Mc from Rc, 42.4% for C-Y from Rb2, and 69.5% for F2 and C-K from Rb1 and Rd. Conclusion: Four monomer minor ginsenosides were successfully produced (at low-cost) from the PPD-ginsenosides using crude enzyme.
AN IDENTITY ON THE 2m-TH POWER MEAN VALUE OF THE GENERALIZED GAUSS SUMS
Liu, Feng,Yang, Quan-Hui Korean Mathematical Society 2012 대한수학회보 Vol.49 No.6
In this paper, using analytic method and the properties of the Legendre's symbol, we prove an exact calculating formula on the $2m$-th power mean value of the generalized quadratic Gauss sums for $m{\geq}2$. This solves a conjecture of He and Zhang [On the 2k-th power mean value of the generalized quadratic Gauss sums, Bull. Korean Math. Soc. 48 (2011), no. 1, 9-15].
Liu, Ye-Qing,Li, Hai-Feng,Han, Jing-Jing,Tang, Qiong-Lan,Sun, Qing,Huang, Zhi-Quan,Li, Hai-Gang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Background: To investigate the expression of CD44v3 and vascular endothelial growth factor-C (VEGF-C) and their relationship with lymph node metastasis in squamous cell carcinomas (SCC) of the uterine cervix. Materials and Methods: Expression of CD44v3 and VEGF-C was analyzed in 109 cases of cervical SCC by immunohistochemistry (IHC). The relationship was analyzed between expression and the patient age, histological differentiation, formation of tumor emboli in lymphoid vessels, lymph node metastasis, FIGO staging, and TNM classification. Results: Expression rates for both CD44v3 and VEGF-C were 43.1% in cervical SCC. The cells with positive immunohistochemical staining of CD44v3 were distributed mainly around the keratin pearls in well differentiated carcinomas, but distributed diffusely in the moderately and poorly differentiated lesions. VEGF-C was found stained positively in most of the tumor cells. There were differences in expression between normal epithelium and atypical hyperplasia as well as carcinoma. Both CD44v3 and VEGF-C were found to be associated positively with lymph node metastasis and TNM classification (both p=0.000). Neither CD44v3 nor VEGF-C was found to be associated with patient age, histological differentiation, formation of tumor emboli in lymphoid vessels and FIGO staging. CD44v3 was found to be associated with VEGF-C positively (p=0.000). Conclusions: Abnormal expression of CD44v3 and VEGF-C is associated closely with the lymph node metastasis in cervical SCC, and these agents may cooperate in carcinogenesis and development of metastatic lesions.
Integrated Protection Unit Design for Power Networks
Zhan-feng Fan,Sheng-ming Ge,Z Q Bo,Lin Wang,Feng-quan Zhou,Xing Liu,Guo-bing Song 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.4
This paper presents an hardware design solution for integrated protection of distribution systems (Network Protection Unit) by combining transient polarity comparison technique, which is based on the detection and processing of fault generated transient current signals. The integrated protection relays installed at each substation of a distribution network are communicated with the Network Protection Unit through specially designed Packet Transport Network (PTN) for fast and reliable transmission of transient polarity current signals. The relay detects the faulted generated super-imposed current signals. The transient polarity identification algorithm is then applied to the super-imposed signals to identify the polarity of the signal detected. The Network Protection Unit can collect all the transient polarity current signals under its protection area. Then The direction of a fault is determined by comparison of the polarity of the signals derived from all the line sections connected to the substation. The actual faulted section is identified by the Network Protection Unit through comparing the directional information from various stations. Simulation results presented in the paper demonstrate the feasibility of the scheme.
Deployment Dynamics of Large-Scale Flexible Solar Arrays with Deployable Mast
Hai-Quan LI,Xiao-Feng LIU,Shao-Jing GUO,Guo-Ping CAI 한국항공우주학회 2017 International Journal of Aeronautical and Space Sc Vol.18 No.2
In this paper, deployment dynamics of large-scale flexible solar arrays with deployable mast is investigated. The adopted solar array system is introduced firstly, then kinematic description and kinematic constraint equations are deduced, and finally, dynamics equation of the system is established by the Jourdain velocity variation principle and a new method to deal with topology changes of the deployable mast is introduced. The dynamic behavior of the system is studied in detail. Simulation results indicate that the proposed model is effective to describe the deployment dynamics of the solar arrays and that the introduced method is applicable for topology changes.
Analytical and Numerical Analysis on a New Type of Bolted Connection for Modular Steel Construction
En-Feng Deng,Jun-Yi Lian,Zhe Zhang,Zhe Liu,Ji-Jian Zhou,Shi-Quan Wang 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.4
Modular steel construction (MSC) has exhibited widespread applications in civil engineering. The inter-module connection is a key issue for the seismic performance of MSC. A detailed finite element model (FEM) of a new type of bolted connection was firstly developed. Its accuracy was validated by comparing numerical results with previous experimental results in terms of hysteretic curve and failure mode. A theoretical mechanical model was developed and its capabilities on predictions of initial rotational stiffness and ultimate moment resistance of the connection were checked through validations against test results. Further, a parametric study on several specimens with different axial load ratios, boundary conditions and section of the beams was conducted. The prediction capability of the theoretical model on seismic behavior of the connection with different beam sections was checked by comparing the skeleton curves of FEA results with theoretical ones. Subsequently, a simplified FEM was established and validated to accelerate the numerical simulation of the seismic performance of the connection.