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- 저자 : Qingqing Dong (검색결과 2 건)
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Jian Chen,Jianzhong Li,Qingqing Dong,Jiutian Xue,Ge Hu 한국항공우주학회 2023 International Journal of Aeronautical and Space Sc Vol.24 No.3
To meet the qualification of temperature rise and reduce emissions, a high temperature rise combustor which is based on RQL (rich-burn/quick-quench/lean-burn) under different primary holes structure had been used to investigate the flow characteristic and combustion performance. The flow field was measured by PIV (particle imaging velocimetry) under different primary holes structure at normal temperature and pressure, and the combustion and emissions performances were simulated under the same conditions in this paper. The results show that the flow field, the airflow mixing effectiveness in the quench zone airflow, the distribution of temperature, the emission and the combustion efficiency change obviously with the primary holes structure. The maximum central recirculation zone height with staggered structure (Case-II) is about 23% higher than that with symmetrical structure. The central recirculation zone length is reduced by 36% and the velocity gradient in the rich zone is increased when the primary holes structure is symmetrical with three holes (Case-I). The insufficient penetration of primary jets has a negative impact to the efficient mixing of the quench zone airflow. Therefore, the symmetrical structure of primary holes is used, increasing the number of holes while reducing the area of single-hole will have a negative impact on the efficient mixing of the quench zone airflow. In addition, when the primary holes structure is symmetrical with four holes (Case-III), the combustion efficiency was reduced by 0.07% and 0.03%, and the maximum emission index of NO was increased by 14% and 19%, respectively, compared with the Case-I and Case-II. On the contrary, the maximum emission index of CO and soot were reduced in rich zone.
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Qian Liu,Zhou Long,Xingyou Dong,Teng Zhang,Jiang Zhao,Bishao Sun,Jingzhen Zhu,Jia Li,Qingqing Wang,Zhenxing Yang,Xiaoyan Hu,Longkun Li 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are confirmed to be expressed in bladder interstitial Cajal-like cells (ICC-LCs), but little is known about their possible role in cystitis-associated bladder dysfunction. The present study aimed to determine the functional role of HCN channels in regulating bladder function under inflammatory conditions. Sixty female wild-type C57BL/6J mice and sixty female HCN1-knockout mice were randomly assigned to experimental and control groups, respectively. Cyclophosphamide (CYP)-induced cystitis models were successfully established in these mice. CYP treatment significantly enhanced HCN channel protein expression and Ih density and significantly altered bladder HCN1 channel regulatory proteins. Carbachol (CCH) and forskolin (FSK) exerted significant effects on bladder ICC-LC [Ca2+]i in CYP-treated wild-type (WT) mice, and HCN1 channel ablation significantly decreased the effects of CCH and FSK on bladder ICC-LC [Ca2+]i in both naive and CYP-treated mice. CYP treatment significantly potentiated the spontaneous contractions and CCH (0.001–10 μM)-induced phasic contractions of detrusor strips, and HCN1 channel deletion significantly abated such effects. Finally, we demonstrated that the development of CYP-induced bladder overactivity was reversed in HCN1 / mice. Taken together, our results suggest that CYP-induced enhancements of HCN1 channel expression and function in bladder ICC-LCs are essential for cystitis-associated bladder hyperactivity development, indicating that the HCN1 channel may be a novel therapeutic target for managing bladder hyperactivity.
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