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- 저자 : Purnamasari Dyah (검색결과 2 건)
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In-hospital malnutrition among adult patients in a national referral hospital in Indonesia
Purnamasari Dyah,Bunawan Nur Chandra,Suseno Dwi,Rinaldi Ikhwan,Dillon Drupadi HS 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.2
BACKGROUND/OBJECTIVES: Malnutrition during hospitalization is linked to increased morbidity and mortality, but there are insufficient studies observing clinical factors contributing to weight loss during hospitalization in Indonesia. This study was therefore undertaken to determine the rate of weight loss during hospitalization and the contributing factors. SUBJECTS/METHODS: This was a prospective study involving hospitalized adult patients aged 18–59 yrs, conducted between July and September 2019. Body weight measurement was taken at the time of admission and on the last day of hospitalization. The factors studied were malnutrition at admission (body mass index < 18.5 kg/m2 ), immobilization, depression (Beck Depression Inventory-II Indonesia), polypharmacy, inflammatory status (neutrophil-lymphocytes ratio; NLR), comorbidity status (Charlson Comorbidity Index; CCI), and length of stay. RESULTS: Totally, 55 patients were included in the final analysis, with a median age of 39 (18-59 yrs) yrs. Of these, 27% had malnutrition at admission, 31% had a CCI score > 2, and 26% had an NLR value of ≥ 9. In all, 62% presented with gastrointestinal symptoms, and depression was documented in one-third of the subjects at admission. Overall, we recorded a mean weight loss of 0.41 kg (P = 0.038) during hospitalization, with significant weight loss observed among patients hospitalized for 7 days or more (P = 0.009). The bivariate analysis revealed that inflammatory status (P = 0.016) was associated with in-hospital weight loss, while the multivariate analysis determined that the contributing factors were length of stay (P < 0.001) and depression (P = 0.019). CONCLUSIONS: We found that inflammatory status of the patient might influence the incidence of weight loss during hospitalization, while depression and length of stay were independent predictors of weight loss during hospitalization.
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( Stevent Sumantri ),( Siti Setiati ),( Esthika Dewiasty ),( Dyah Purnamasari ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Type 2 diabetes (T2DM) was characterised with insulin resistance and defi ciency, furthermore with advancing age the was also an increase in insulin resistance. Clinical studies has proven that insulin resistance and T2DM increase the incidence of frailty syndrome in the elderly. Oral antidiabetics metformin was associated with the inhibition of aging process. Eventhough, there was no data that showed the relationship of metformin therapy to frailty syndrome. Methods: This was a case control study conducted in subjects =60 years old who visited the Geriatrics and Diabetes outpatient clinic of Cipto Mangunkusumo National Referral Hospital between March and June 2013. Diagnosis of frailty was established using the fi-40 item criteria. Statistical analysis was done with SPSS 20. 0, where chisquare method was used in bivariate and logistic regression method in multivariate analysis. Results: Frailty syndrome was found in 25% of subjects (n=59), with median age of 72 years old (SD 6. 27) and median of fi-40 item score was 0. 18 (SD 0. 085). Metformin was found to have a signifi cant relationship with frailty syndrome in the elderly diabetics, which retained signifi cant value after multivariate analysis (adjusted OR 0. 043; 95% CI 0. 019-0. 099; p<0. 001). Conclusions: Metformin was associated with independently lower risk of frailty syndrome in elderly diabetics.
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